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The Crystal Structure of a GroEL/Peptide Complex
Open accessAbstract
The chaperonin GroEL is a double toriodal assembly that with its cochaperonin GroES facilitates protein folding with an ATP-dependent mechanism. Nonnative conformations of diverse protein substrates bind to the apical domains surrounding the opening of the double toroid's central cavity. Using phage display, we have selected peptides with high affinity for the isolated apical domain. We have determined the crystal structures of the complexes formed by the most strongly bound peptide with the isolated apical domain, and with GroEL. The peptide interacts with the groove between paired alpha helices in a manner similar to that of the GroES mobile loop. Our structural analysis, combined with other results, suggests that various modes of molecular plasticity are responsible for tight promiscuous binding of nonnative substrates and their release into the shielded cis assembly.
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Cited by
Molecular Chaperones in the Cytosol: from Nascent Chain to Folded Protein
Hartl, F. U., & Hayer-Hartl, M. (2002) · Science · doi:10.1126/science.1068408 · Cited by 3,347
Kinbara, K., & Aida, T. (2005) · Chemical Reviews · doi:10.1021/cr030071r · Cited by 865
Herzog, F., Kahraman, A., Boehringer, D., Mak, R., Bracher, A., Walzthoeni, T., Leitner, A., Beck, M., Hartl, F.-U., Ban, N., et al. (2012) · Science · doi:10.1126/science.1221483 · Cited by 371
Chaperone-Bound Clients: The Importance of Being Dynamic
Hiller, S. (2019) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2018.12.005 · Cited by 54
Burgos, R., Weber, M., Martinez, S., Lluch‐Senar, M., & Serrano, L. (2020) · Molecular Systems Biology · doi:10.15252/msb.20209530 · Cited by 39
Metadata
- Authors
- Chen, L., & Sigler, P. B.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1999-12
- Volume
- 99
- Issue
- 7
- Pages
- 757-768
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2039486080
- Cited by
- 241
- References
- 0
- FWCI
- 7.94
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Chen, L., & Sigler, P. B. (1999). The Crystal Structure of a GroEL/Peptide Complex. Cell. https://doi.org/10.1016/s0092-8674(00)81673-6
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