Oxygen and Wound Healing
Abstract
Surgeons have been aware of the detrimental effect of ischemia and hypoxia on healing tissues. In order to assist repair in such circumstances, a variety of modalities including revascularization, flaps, and hyperbaric O2 have been developed. Although these are apparently successful from a clinical standpoint, only recently has experimental evidence demonstrated conclusively that oxygen is a controlling factor in wound repair. Furthermore, it is now clear that traditional expectations of repair can often be exceeded by increasing the partial pressure at which oxygen is supplied to wounds.
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The proliferative phase of wound healing involves cell proliferation, angiogenesis, new extracellular matrix deposition, and granulation tissue formation, processes largely mediated by the local microenvironment (pH, oxygen tension) and cytokines secreted by macrophages, T lymphocytes, and other wound-site cells.
“The proliferative phase of wound healing involves cellular proliferation, angiogenesis, new ECM deposition, and the formation of granulation tissue – processes that are largely mediated via the effects of the local microenvironment including pH and oxygen tension, and cytokines secreted by macrophages, T lymphocytes, and other cells within the wound site [91,98,99].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [99]
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Brown, B. N., Ratner, B. D., Goodman, S. B., Amar, S., & Badylak, S. F. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.02.034 · Cited by 926 · see citing works
- Authors
- LaVan, F. B., & Hunt, T. K.
- Affiliations
- Graduate Hospital (US)
- University of California, San Francisco (US)
- Venue
- Clinics in Plastic Surgery
- Publisher
- Elsevier BV
- Published
- 1990-07
- Volume
- 17
- Issue
- 3
- Pages
- 463-472
- ISSN
- 0094-1298 (ISSN-L)
- OpenAlex
- W2126068876
- Cited by
- 273
- References
- 0
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 7 · 2021: 9 · 2020: 12 · 2019: 2 · 2018: 4 · 2017: 5 · 2016: 6 · 2015: 11 · 2014: 6 · 2013: 7 · 2012: 13
- FWCI
- 6.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinics in Plastic Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- wound healing, oxygen, hypoxia, ischemia, hyperbaric oxygen therapy, revascularization, flaps, tissue repair, oxygen partial pressure
- MeSH terms
- Humans, Hyperbaric Oxygenation, Oxygen, Oxygen Consumption, Wound Healing, Wounds and Injuries
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