Lithium-induced increase in human brain grey matter
Abstract
Rodent studies have shown that lithium exerts neurotrophic or neuroprotective effects. We used three-dimensional magnetic resonance imaging and brain segmentation to study pharmacologically-induced increases in grey matter volume with chronic lithium use in patients with bipolar mood disorder. Grey-matter volume increased after 4 weeks of treatment. The increases in grey matter probably occurred because of neurotrophic effects.
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Lithium can restore PFC activity and grey matter levels in patients with bipolar disorder.
“There is recent evidence that lithium can restore PFC activity and grey matter levels in patients with bipolar disorder141–143.”
From Stress signalling pathways that impair prefrontal cortex structure and function (2009) · cites this paper as [143]
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References 9 · Cited by 649
- Authors
- Moore, G. J., Bebchuk, J. M., Wilds, I. B., Chen, G., & Menji, H. K.
- Affiliations
- Wayne State University (US)
- Corresponding author
- Moore, Gregory J
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2000-10
- Volume
- 356
- Issue
- 9237
- Pages
- 1241-1242
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2069247119
- Cited by
- 649
- References
- 9
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 7 · 2023: 5 · 2022: 10 · 2021: 29 · 2020: 25 · 2019: 14 · 2018: 13 · 2017: 14 · 2016: 28 · 2015: 21 · 2014: 26 · 2013: 23 · 2012: 33
- FWCI
- 19.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh059107-03)
- National Institute of Mental Health (MH59107)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- lithium, gray matter volume, neurotrophic effects, neuroprotection, bipolar disorder, chronic lithium treatment, brain segmentation, 3D MRI
- MeSH terms
- Adolescent, Adult, Aspartic Acid, Bipolar Disorder, Brain, Female, Humans, Lithium, Magnetic Resonance Imaging, Male, Middle Aged, Neuroprotective Agents
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