Matrix metalloproteinase-1 and skin ageing in smokers
Abstract
Smokers look older than non-smokers of the same age. We have compared the concentrations of mRNA for matrix metalloproteinase 1 (MMP-1) in the buttock skin of smokers and non-smokers with quantitative real-time polymerase chain reactions. MMP-1 degrades collagen, which accounts for at least 70% of the dry weight of dermis. We report significantly more MMP-1 mRNA in the skin of smokers than non-smokers whereas no difference was seen for the tissue inhibitor of metalloproteinases 1 (TIMP-1) or the housekeeping gene GAPDH (glyceraldehyde-3-phosphate dehydrogenase). We suggest that smoking-induced MMP-1 might be important in the skin-ageing effects of tobacco smoking.
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The underlying mechanism for skin senescence is activation of metalloproteinases in smokers compared with non-smokers.
“Lahmann and colleagues showed that the underlying mechanism for skin senescence is the activation of metalloproteinases (MMPs) in smokers compared to non-smokers [34].”
From Skeletal System Biology and Smoke Damage: From Basic Science to Medical Clinic (2021) · cites this paper as [34]
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References 5 · Cited by 206
- Authors
- Lahmann, C., Bergemann, J., Harrison, G., & Young, A. R.
- Affiliations
- Beiersdorf (Germany) (DE)
- Albstadt-Sigmaringen University (DE)
- St Thomas' Hospital (GB)
- Corresponding author
- Young, Antony R
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2001-03
- Volume
- 357
- Issue
- 9260
- Pages
- 935-936
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2073423892
- Cited by
- 206
- References
- 5
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 9 · 2022: 7 · 2021: 10 · 2020: 6 · 2019: 5 · 2018: 4 · 2017: 4 · 2016: 17 · 2015: 9 · 2014: 6 · 2013: 7 · 2012: 5
- FWCI
- 13.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- MMP-1, skin aging, smoking, TIMP-1, collagen degradation, dermis, smokers versus non-smokers
- MeSH terms
- Adult, Female, Humans, Male, RNA, Messenger, Smoking, Skin Aging, Matrix Metalloproteinase 1
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