Itch
Abstract
Itch is a common skin sensation, with substantial effects on behaviour. Neurophysiological research has permitted accurate definition of neural pathways of itch, and has confirmed the distinctiveness of itch pathways in comparison with pain. A clinical classification of itch, based on such improved understanding, describes the difference between peripheral (pruritoceptive) and central (neurogenic or neuropathic) itch. New specific and sensitive investigational methods in people and animals enable us to better understand this bothersome symptom, and have important clinical implications. We describe the clinical classification of itch, new findings on neuropathophysiology of itch, methods for assessment, and improved treatments.
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Itch shares some similarity with pain as both are unpleasant sensations with common pathophysiological features.
“Itch shares some similarity with pain (17) as both are unpleasant sensations with common pathophysiological features (18).”
From Mindfulness as Predictor of Itch Catastrophizing in Patients With Atopic Dermatitis: Results of a Cross-Sectional Questionnaire Study (2021) · cites this paper as [18]
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References 69 · Cited by 388
- Authors
- Yosipovitch, G., Greaves, M. W., & Schmelz, M.
- Affiliations
- Wake Forest University Health Sciences (US)
- University Kebangsaan Malaysia Medical Centre (MY)
- University of Mannheim (DE)
- Corresponding author
- Yosipovitch, Gil
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2003-02
- Volume
- 361
- Issue
- 9358
- Pages
- 690-694
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W4239319745
- Cited by
- 388
- References
- 69
- Citations by year
- 2026: 7 · 2025: 15 · 2024: 12 · 2023: 14 · 2022: 10 · 2021: 27 · 2020: 16 · 2019: 16 · 2018: 19 · 2017: 18 · 2016: 20 · 2015: 16 · 2014: 16 · 2013: 16 · 2012: 16
- FWCI
- 3.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- pruritus, neuropathic itch, neuropathophysiology
- MeSH terms
- Animals, Antipruritics, Humans, Nervous System Physiological Phenomena, Pruritus
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