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Prediction of pathogenic mutations in patients with early-onset breast cancer by family history
Abstract
We aimed to assess frequency and penetrance of BRCA1, BRCA2,and TP53 mutations in women diagnosed with breast cancer aged 30 years or younger, and then correlate this frequency with family history. 17 of 36 familial cases had a BRCA1, BRCA2, or TP53 mutation, compared with three of 63 non-familial cases. The calculated population frequency of TP53 mutations was one in 5000, substantially greater than previous estimates. This finding underlines the importance of accurate elucidation of a family history from young women diagnosed with breast cancer. Establishment of family history could help with development of patient-specific management and tumour surveillance protocols.
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“Lalloo et al (2003, 2006) reported on the frequency and penetrance of BRCA1/2 and TP53 mutations in early-onset breast cancer in earlier papers. These papers showed a predominance of BRCA1/2 mutations in familial aggregations of breast cancer, with penetrance estimates of breast cancer as high as 80–90% by 70 years of age.”
From Long-term outcomes of breast cancer in women aged 30 years or younger, based on family history, pathology and BRCA1/BRCA2/TP53 status (2010) · cites this paper as Lalloo et al, 2003
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Cites
Ford, D., Easton, D., Stratton, M. R., Narod, S., Goldgar, D., Devilee, P., Bishop, D., Weber, B., Lenoir, G., Chang-Claude, J., et al. (1998) · American Journal of Human Genetics · doi:10.1086/301749 · Cited by 2,766
Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium.
Easton, D. F., Ford, D., & Bishop, D. T. (1995) · PubMed Central · Cited by 1,602
Anglian Breast Cancer Study Group (2000) · British Journal of Cancer · doi:10.1054/bjoc.2000.1407 · Cited by 602
Prevalence and diversity of constitutional mutations in the p53 gene among 21 Li-Fraumeni families
Birch, Hartley, Tricker, Prosser, P., Condie, Kelsey, Harris, Jones, Binchy, Crowther, et al. (1994) · Cancer Research · Cited by 475
Prevalence and diversity of constitutional mutations in the p53 gene among 21 Li-Fraumeni families.
Birch, J. M., Hartley, A. L., Tricker, K. J., Prosser, J., Condie, A., Kelsey, A. M., Harris, M., Jones, P. H. M., Binchy, A., & Crowther, D. (1994) · PubMed · Cited by 421
Breast and ovarian cancer incidence in BRCA1-mutation carriers
Easton, D., Ford, D., Bishop, D., Haites, N., Milner, B., Allan, L., Ponder, B., Peto, J., Smith, S., Ford, D., et al. (1995) · UCL Discovery (University College London) · Cited by 301
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Evans, D. G., Harkness, E. F., Howel, S., Woodward, E. R., Howell, A., & Lalloo, F. I. (2017) · Breast Cancer Research and Treatment · doi:10.1007/s10549-017-4557-1 · Cited by 17
Self-citationSystematic Analysis of Free-Text Family History in Electronic Health Record.
(2017) · PubMed Central · Cited by 16
Cancer surveillance for patients with Li-Fraumeni Syndrome in Brazil: A cost-effectiveness analysis
Frankenthal, I. A., Alves, M. C., Tak, C. R., & Achatz, M. I. (2022) · The Lancet Regional Health - Americas · doi:10.1016/j.lana.2022.100265 · Cited by 15
Biogenic nanoparticles: pioneering a new era in breast cancer therapeutics—a comprehensive review
Bhat, S. A., Kumar, V., Dhanjal, D. S., Gandhi, Y., Mishra, S. K., Singh, S., Webster, T. J., & Ramamurthy, P. C. (2024) · Discover Nano · doi:10.1186/s11671-024-04072-y · Cited by 15
Warby, M., Wakefield, C. E., Vetsch, J., & Tucker, K. (2018) · Clinical Genetics · doi:10.1111/cge.13442 · Cited by 15
Germline Variants and Characteristic Features of Hereditary Hematological Malignancy Syndrome
Arai, H., Matsui, H., Chi, S., Utsu, Y., Masuda, S., Aotsuka, N., & Minami, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25010652 · Cited by 14
Clinical utility of testing for PALB2 and CHEK2 c.1100delC in breast and ovarian cancer
Woodward, E. R., van Veen, E. M., Forde, C., Harkness, E. F., Byers, H., Ellingford, J. M., Burghel, G. J., Schlech, H., Bowers, N. L., Wallace, A. J., et al. (2021) · Genetics in Medicine · doi:10.1038/s41436-021-01234-6 · Cited by 16
Self-citationShin, S. J., Yuan, Y., Strong, L. C., Bojadzieva, J., & Wang, W. (2018) · Journal of the American Statistical Association · doi:10.1080/01621459.2018.1482749 · Cited by 14
The BRCA2 polymorphic stop codon: stuff or nonsense?
Higgs, J. E., Harkness, E. F., Bowers, N. L., Howard, E., Wallace, A. J., Lalloo, F. I., Newman, W. G., & Evans, D. G. (2015) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2015-103206 · Cited by 13
Self-citationEvans, D. G., & Woodward, E. R. (2020) · Familial Cancer · doi:10.1007/s10689-020-00207-z · Cited by 15
Self-citationThe dichotomy of p53 regulation by noncoding RNAs
Deng, Q., Becker, L., Ma, X., Zhong, X., Young, K. H., Ramos, K. S., & Li, Y. (2014) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mju017 · Cited by 14
The art of healing broken hearts in breast cancer patients: Trastuzumab and heart failure.
Walker, J. R., Singal, P. K., & Jassal, D. S. (2009) · PubMed Central · Cited by 12
McVeigh, T. P., Sweeney, K., Brennan, D. J., McVeigh, U. M., Ward, S., Strydom, A., Seal, S., Astbury, K., Donnellan, P. P., Higgins, J., et al. (2022) · Familial Cancer · doi:10.1007/s10689-022-00313-0 · Cited by 11
Penkert, J., Schlegelberger, B., Steinemann, D., & Gadzicki, D. (2012) · Familial Cancer · doi:10.1007/s10689-012-9556-0 · Cited by 10
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Shin, S. J., Li, J., Ning, J., Bojadzieva, J., Strong, L. C., & Wang, W. (2018) · Biostatistics · doi:10.1093/biostatistics/kxy066 · Cited by 10
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Janavičius, R., Andrėkutė, K., Mickys, U., Rudaitis, V., Brasiūnienė, B., & Griškevičius, L. (2011) · The Breast Journal · doi:10.1111/j.1524-4741.2011.01088.x · Cited by 9
Berry, D. K., Gillis, N., Padron, E., Moore, C. E., Barton, L., Gewandter, K. R., Haskins, C. G., & Knepper, T. C. (2023) · Journal of Genetic Counseling · doi:10.1002/jgc4.1789 · Cited by 8
Stoltze, U. K., Skytte, A., Roed, H., Hasle, H., Ejlertsen, B., Hansen, T. V. O., Schmiegelow, K., Gerdes, A., & Wadt, K. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190050 · Cited by 8
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Cui, C., Li, L., & Zhen, J. (2018) · Medical Oncology · doi:10.1007/s12032-018-1130-7 · Cited by 8
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Evans, D. G., van Veen, E. M., Woodward, E. R., Harkness, E. F., Ellingford, J. M., Bowers, N. L., Wallace, A. J., Howell, S. J., Howell, A., Lalloo, F. I., et al. (2021) · Cancers · doi:10.3390/cancers13164154 · Cited by 8
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Walsh, M. F., Cadoo, K. A., Salo‐Mullen, E. E., Dubard-Gault, M. E., Stadler, Z. K., & Offit, K. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-47674-4.00013-x · Cited by 10
Hagag, E., Shwaireb, M. H., Coffa, J., & Wakil, A. E. (2013) · Eastern Mediterranean Health Journal · doi:10.26719/2013.19.3.255 · Cited by 8
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Birch, J. M. (2005) · doi:10.1002/9780470994733.ch2 · Cited by 5
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Kassem, N., Stout, L. A., Hunter, C., Schneider, B., & Radovich, M. (2020) · JCO Precision Oncology · doi:10.1200/po.19.00278 · Cited by 5
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Watanabe, T., Soeda, S., Okoshi, C., Fukuda, T., Yasuda, S., & Fujimori, K. (2023) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.15766 · Cited by 4
Nguyen, N. H., Dodd-Eaton, E. B., Peng, G., Corredor, J. L., Jiao, W., Woodman-Ross, J., Arun, B., & Wang, W. (2024) · JCO Clinical Cancer Informatics · doi:10.1200/cci.23.00167 · Cited by 4
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Boruah, N., Hoyos, D., Moses, R., Hausler, R. M., Desai, H., Le, A. D., Good, M., Kelly, G., Raghavakaimal, A., Tayeb, M. N., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-73163-4 · Cited by 4
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Evans, D. G. (2011) · Medicine · doi:10.1016/j.mpmed.2011.09.013 · Cited by 4
Self-citationRobays, J., Stordeur, S., Hulstaert, F., Maerken, T. V., Claes, K., Janin, N., Matthijs, G., de Roodenbeke, D. '. K., Berlière, M., Wildiers, H. P. M. W., et al. (2015) · doi:10.57598/r236c · Cited by 4
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BRCA2 mutation screening is clinically relevant in breast and early prostate cancer families
Azzouzi, A., Stoppa‐Lyonnet, D., Morgan Rouprêt, A., Larré, S., Mangin, P., & Cussenot, O. (2007) · International Journal of Urology · doi:10.1111/j.1442-2042.2006.01712.x · Cited by 3
Shin, S. J., Yuan, Y., Strong, L. C., Bojadzieva, J., & Wang, W. (2017) · arXiv (Cornell University) · doi:10.48550/arxiv.1701.01558 · Cited by 3
Advolodkina, P., Lachiewicz, M. P., Oprea‐Ilies, G., Majmudar, B., & Gordon, A. N. (2018) · Gynecologic and Obstetric Investigation · doi:10.1159/000489261 · Cited by 2
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Hamoode, R. H., Al-Ani, M. Q., & Turkey, F. A. (2018) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2018.v11i5.24423 · Cited by 1
由記子, 恒. (2010) · doi:10.18976/jsft.10.2_75 · Cited by 1
Antoniou, A. C., Pharoah, P. D. P., Cunningham, A. P., & Easton, D. F. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602488 · Cited by 1
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Nguyen, N. H., Shin, S. J., Dodd-Eaton, E. B., Ning, J., & Wang, W. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.28.530537 · Cited by 1
Parham, E. A. (2014) · Digital Commons-TMC (Texas Medical Center)
Magnusson, S. (2012) · Lund University Publications (Lund University)
Basta, N. O. (2011) · The Open Breast Cancer Journal · doi:10.2174/1876817201103010006
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Grochola, L. F., Zerón-Medina-Cuairán, J., Repapi, E., Finlayson, A. E. T., Cai, Y., Atwal, G. S., & Bond, G. L. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3676-8_2
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Müller, U. R., & Helbling, A. (2014) · doi:10.2217/fmeb2013.13.25
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Ahmed, H. (2018) · TSpace (University of Toronto)
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Chen, L., Huang, M., Chen, M., Lin, Y., Li, J., Guo, W., Wang, C., & Fu, F. (2022) · Research Square · doi:10.21203/rs.3.rs-1200021/v1
Fu, F., Chen, L., Huang, M., Chen, M., Lin, Y., Li, J., Guo, W., & Wang, C. (2022) · Research Square · doi:10.21203/rs.3.rs-1200021/v2
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Walsh, C., & Strong, L. C. (2008) · CRC Press eBooks · doi:10.3109/9781420052886-16
Chen, L., Huang, M., Chen, M., Lin, Y., Li, J., Guo, W., Wang, C., & Fu, F. (2022) · Research Square · doi:10.21203/rs.3.rs-1200021/v3
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Metadata
- Authors
- Lalloo, F., Varley, J., Ellis, D., Moran, A., O'Dair, L., Pharoah, P., & Evans, D. G. R.
- Affiliations
- St Mary's Hospital (GB)
- Cancer Research UK Manchester Institute (GB)
- Guy's Hospital (GB)
- University of Manchester (GB)
- University of Cambridge (GB)
- Corresponding author
- Lalloo, Fiona
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2003-03
- Volume
- 361
- Issue
- 9363
- Pages
- 1101-1102
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2089797982
- Cited by
- 202
- References
- 6
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 9 · 2022: 9 · 2021: 10 · 2020: 10 · 2019: 14 · 2018: 16 · 2017: 14 · 2016: 4 · 2015: 12 · 2014: 7 · 2013: 8 · 2012: 13
- FWCI
- 3.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- DigitalGeorgetown (Georgetown University Library) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
- Health Sciences › Medicine › Pathology and Forensic Medicine › Breast Lesions and Carcinomas
- Health Sciences › Medicine › Epidemiology › Multiple and Secondary Primary Cancers
- Keywords
- early-onset breast cancer, BRCA1 mutation, BRCA2 mutation, TP53 mutation, pathogenic variants, family history (medicine), mutation frequency, mutation penetrance, hereditary breast cancer, tumor surveillance
- MeSH terms
- Adult, Age Factors, Breast Neoplasms, DNA Mutational Analysis, Female, Gene Frequency, Genetic Testing, Humans, Tumor Suppressor Protein p53, Risk Assessment, BRCA1 Protein, Penetrance, Genetic Predisposition to Disease, BRCA2 Protein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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