The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Severe cutaneous papillomavirus disease after haemopoietic stem-cell transplantation in patients with severe combined immune deficiency caused by common γc cytokine receptor subunit or JAK-3 deficiency
Abstract
Haemopoietic stem-cell transplantation is a life-saving treatment for severe combined immune deficiency. However, there has been little long-term follow-up of this treatment. There is evidence for the persistance of partial immunodeficiency associated with significant infections, including severe human papillomavirus (HPV) disease. We did a retrospective analysis of severe HPV disease in a group of 41 patients with severe combined immune deficiency from one centre who were alive 10 years or longer after haemopoietic stem-cell transplantation. Nine of the 41 patients had extensive chronic HPV disease limited to the skin, with a median onset at 8 years after transplantation. Four had lesions typical of epidermodysplasia verruciformis, a rare genodermatosis. Transplant characteristics, immune status, and chimerism of these nine patients did not differ significantly from those of the other patients. The nine patients with HPV disease had severe combined immune deficiency associated with either common gammac receptor cytokine subunit or Janus kinase-3 (JAK-3) deficiency. By contrast, patients with other forms of severe combined immune deficiency did not have any signs of HPV disease. That genetic causes are the only predisposing factor to be identified for severe combined immune deficiency, suggests that natural-killer cells or gammac/JAK-3-dependent signalling in keratinocytes could have a role in anti-HPV immunity.
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“The hypothesis of a keratinocyte contribution to EV in these patients is supported by the appearance of EV lesions on the skin of JAK3-and IL2-Rγ-deficient patients after bone marrow transplantation, particularly in cases of successful T cell engraftment (55).”
From Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections (2012) · cites this paper as [55]
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Hernandez, P. A., Gorlin, R. J., Lukens, J. N., Taniuchi, S., Bohinjec, J., Francois, F., Klotman, M. E., & Diaz, G. A. (2003) · Nature Genetics · doi:10.1038/ng1149 · Cited by 722
Research works printed but not linked: 6
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- Buckley, 1999, Hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency, N Engl J Med, 340, 508, 10.1056/NEJM199902183400703 · DOI
- Antoine, 2003, Long-term survival and transplantation of haemopoietic stem cells for immunodeficiencies: report of the European experience 1968–99, Lancet, 361, 553, 10.1016/S0140-6736(03)12513-5 · DOI
- Ramoz, 2002, Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis, Nat Genet, 32, 579, 10.1038/ng1044 · DOI
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Cited by
Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections
Crequer, A., Troeger, A., Patin, E., Ma, C. S., Picard, C., Pedergnana, V., Fieschi, C., Lim, A., Abhyankar, A., Gineau, L., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci62949 · Cited by 159
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Metadata
- Authors
- Laffort, C., Deist, F. L., Favre, M., Caillat-Zucman, S., Radford-Weiss, I., Fraitag, S., Blanche, S., Cavazzana-Calvo, M., Basile, G. D. S., de Villartay, J. P., Giliani, S., Orth, G., Casanova, J. L., Bodemer, C., Fischer, A., & Debré, M.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2004-06
- Volume
- 363
- Issue
- 9426
- Pages
- 2051-2054
- ISSN
- 0140-6736
- Cited by
- 145
- References
- 1
- Language
- en
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- The paper
- Laffort, C., Deist, F. L., Favre, M., Caillat-Zucman, S., Radford-Weiss, I., Fraitag, S., Blanche, S., Cavazzana-Calvo, M., Basile, G. D. S., de Villartay, J. P., Giliani, S., Orth, G., Casanova, J. L., Bodemer, C., Fischer, A., & Debré, M. (2004). Severe cutaneous papillomavirus disease after haemopoietic stem-cell transplantation in patients with severe combined immune deficiency caused by common γc cytokine receptor subunit or JAK-3 deficiency. The Lancet. https://doi.org/10.1016/s0140-6736(04)16457-x
