The DOI matches its Crossref record.
Misleading use of risk ratios
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Claims the paper makes
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Each is checked against this paper’s own text: does it say what the citing paper says it does?
A 50% risk ratio for a drug tested in 100 people that reduces two deaths to one death is the same as the risk ratio for a drug tested in 1000 people that reduces two deaths to one death.
“The authors pointed out that a 50% risk ratio for a drug tested in 100 people that reduces two deaths to one death (0.01 / 0.02 = 0.5) is the same as the risk ratio for a drug tested in a larger group of 1000 people that reduces two deaths to one death (0.001 / 0.002 = 0.5).”
From Relative risk reduction: Misinformative measure in clinical trials and COVID-19 vaccine efficacy (2022) · cites this paper as [12]
Relative risk does not measure risk at all, because risk has dimensions, while a risk ratio has no dimensions.
“Relative risk does not measure ‘risk’ at all, because risk has dimensions, such as observed deaths per 100 or 1000 people. However, a risk ratio has no dimensions because they cancel in calculating the ratio”
From Relative risk reduction: Misinformative measure in clinical trials and COVID-19 vaccine efficacy (2022) · cites this paper as [12]
The change from two deaths per 100 people to one death per 100 people is a 1% decreased risk, and the change from two deaths per 1000 people to one death per 1000 people is a 0.1% decreased risk, ten times smaller.
“Using absolute measures, the authors showed that “the change from two deaths per 100 people to one death per 100 people is a 1% decreased risk,” (ARR: 0.02 – 0.01 = 0.01 * 100 = 1%). “And the change from two deaths per 1000 people to one death per 1000 people is a 0.1% decreased risk,” (ARR: 0.002 – 0.001 = 0.001 * 100 = 0.1%), which is ten times smaller in magnitude than the decreased risk per 10”
From Relative risk reduction: Misinformative measure in clinical trials and COVID-19 vaccine efficacy (2022) · cites this paper as [12]
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 3
- Jackson, 2005, Treating Individuals 5: Treatment with drugs to lower blood pressure and blood cholesterol based on an individual's absolute cardiovascular risk, Lancet, 365, 434, 10.1016/S0140-6736(05)70240-3 · DOI
- Chlebowski, 2003, Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women's Health Initiative randomized trial, JAMA, 289, 3243, 10.1001/jama.289.24.3243 · DOI
- Gann, 2003, Combined hormone replacement therapy and breast cancer: a single-edged sword, JAMA, 289, 3303, 10.1001/jama.289.24.3304 · DOI
Cited by
Sorted by citations
Relative risk reduction: Misinformative measure in clinical trials and COVID-19 vaccine efficacy
Brown, R. B. (2022) · Dialogues in Health · doi:10.1016/j.dialog.2022.100074 · Cited by 11
“However, a risk ratio has no dimensions because they cancel in calculating the ratio ” [12].”
Metadata
- Authors
- Stadel, B. V., Colman, E., & Sahlroot, T.
- Affiliations
- United States Food and Drug Administration (US)
- Corresponding author
- Stadel, Bruce V
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2005-04
- Volume
- 365
- Issue
- 9467
- Pages
- 1306-1307
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2018541377
- Cited by
- 5
- References
- 0
- Citations by year
- 2024: 1 · 2022: 2
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Epidemiology
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
- Keywords
- relative risk, relative risk reduction, number needed to treat, absolute risk, risk communication, Women's Health Initiative, breast cancer screening
- MeSH terms
- Humans, Risk, Odds Ratio, Drug-Related Side Effects and Adverse Reactions
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