Misdiagnosis of multiple sclerosis and β-interferon
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Non-specific white matter lesions are common in older individuals and in those with vascular risk factors including migraine; a single periventricular lesion is not uncommon.
“However, non-specific white matter lesions are common in older individuals and in those with vascular risk factors including migraine; a single periventricular lesion is not uncommon. 16”
From Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria (2018) · cites this paper as [16]
In “Misdiagnosis of multiple sclerosis and β-interferon” (page unavailable), Poser says many conditions cause MRI lesions that mimic multiple sclerosis, supporting the general caution about nonspecific lesions. Our copy does not say that such lesions are common in older people or those with vascular risk factors, characterize migraine as a vascular risk factor, or address how common a single periventricular lesion is. (LLM, conf=0.77)
Experimental — accuracy not yet measuredA 1997 study of 366 patients with a diagnosis of MS referred for a second opinion to Charles Poser found 130 misdiagnosed patients, including 28 (22%) with chronic fatigue syndrome and eight (6%) with 'psychiatric disorder' or 'post-traumatic syndrome'.
“A 1997 study of 366 patients with a diagnosis of MS referred for a second opinion to Charles Poser found 130 misdiagnosed patients, including 28 (22%) with chronic fatigue syndrome and eight (6%) with “psychiatric disorder” or “post-traumatic syndrome” [32].”
From Functional neurological disorder and multiple sclerosis: a systematic review of misdiagnosis and clinical overlap (2022) · cites this paper as [32]
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Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria
Thompson, A. J., Banwell, B. L., Barkhof, F., Carroll, W. M., Coetzee, T., Comi, G., Correale, J., Fazekas, F., Filippi, M., Freedman, M. S., et al. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30470-2 · Cited by 8,167 · see citing works
The contemporary spectrum of multiple sclerosis misdiagnosis
Solomon, A. J., Bourdette, D. N., Cross, A. H., Applebee, A., Skidd, P. M., Howard, D. B., Spain, R. I., Cameron, M. H., Kim, E., Mass, M. K., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000003152 · Cited by 334 · see citing works
Incidence of multiple sclerosis misdiagnosis in referrals to two academic centers
Kaisey, M., Solomon, A. J., Luu, M., Giesser, B. S., & Sicotte, N. L. (2019) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2019.01.048 · Cited by 148 · see citing works
Walzl, D., Solomon, A. J., & Stone, J. (2022) · Journal of Neurology · doi:10.1007/s00415-021-10436-6 · Cited by 62 · see citing works
- Authors
- Poser, C. M.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Poser, Charles M
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1997-06
- Volume
- 349
- Issue
- 9069
- Pages
- 1916
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2005150154
- Cited by
- 43
- References
- 0
- Citations by year
- 2024: 2 · 2023: 2 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 2 · 2013: 2 · 2012: 1
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Family Practice › Clinical Reasoning and Diagnostic Skills
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Keywords
- multiple sclerosis, misdiagnosis, interferon-beta, interferon therapy, second opinion, magnetic resonance imaging, differential diagnosis, disseminated encephalomyelitis, chronic fatigue syndrome, myelopathy, post-traumatic syndrome, complicated migraine, mental illness, diagnostic criteria, overprescribing, cost-effectiveness
- MeSH terms
- Diagnostic Errors, Humans, Magnetic Resonance Imaging, Multiple Sclerosis, Interferon-beta
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