The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
COX-2 selectivity alone does not define the cardiovascular risks associated with non-steroidal anti-inflammatory drugs
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“In general, all nontopical NSAIDs in doses adequate to reduce inflammation and pain can affect BP levels in both normotensive and hypertensive individuals.182”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [182]
Citations
Cites
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Effects of Nonsteroidal Antiinflammatory Drugs on Platelet Function and Systemic Hemostasis
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“36 Moreover, NSAIDs themselves have been linked to hypertension, 36 41 which is an established independent risk factor for the development of CKD.”
Current and Emerging Treatments for Mild/Moderate Acute Ambulatory Pain
Weaver, A. L. (2008) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e31818be66f · Cited by 7
“The clinical result is that aspirin, NSAIDs, and coxibs reduce pain, inflammation, fever, and urinary prostaglandin I2 metabolites and increase blood pressure, but only aspirin and NSAIDs reduce urinary thromboxane A2 metabolites, inhibit platelets, increase bleeding time, and promote GI toxicity.(2) The major limitat…”
BackgroundMariano, A., Russo, R., d’Abusco, A. S., & Superti, F. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47090731 · Cited by 6
“In addition, NSAIDs may also cause allergic reactions [16] and increase the risk of hypertension and fluid retention [17].”
NSAIDs and anastomotic leak: What's the evidence?
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Marini, I., Cavallaro, M., Bartolucci, M. L., Alessandri‐Bonetti, A., Gatto, M. R., Cordaro, M., & Checchi, L. (2018) · Journal of Translational Science · doi:10.15761/jts.1000255 · Cited by 6
“Although NSAIDs provide excellent pain control for arthritis patients, NSAIDs overuse has been associated with increased risks of gastrointestinal complications [10,11] and cardiovascular events [12] which can limit their prolonged use, therefore innovative therapeutic strategies are needed.”
BackgroundInhibiting thrombosis without causing bleeding: can EP3 blockers fulfil the dream?
Caterina, R. D. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu020 · Cited by 6
Drugs for Pain, Inflammation, and Arthritic Disorders
Brenner, G. M., & Stevens, C. W. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-6627-9.00030-5 · Cited by 5
Lacza, Z., Hortobágyi, L., Horváth, B., Horvath, E. M., Sándor, P., & Benyó, Z. (2009) · Neuroreport · doi:10.1097/wnr.0b013e32832d6a93 · Cited by 5
Nonsteroidal Anti-Inflammatory Drugs and Coxibs
Kvien, T. K. (2009) · Elsevier eBooks · doi:10.1016/b978-032305475-1.50041-0 · Cited by 5
How to manage musculoskeletal conditions
Conaghan, P. G., & Brooks, P. (2008) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2008.02.004 · Cited by 5
Mangoni, A. A., Crilly, M., & Knights, K. (2011) · Expert Review of Clinical Pharmacology · doi:10.1586/ecp.11.12 · Cited by 5
Saod, L. A. F. B., & Albhbah, W. (2024) · The Scientific Journal of University of Benghazi · doi:10.37376/sjuob.v37i2.7125 · Cited by 4
Soto, N. Y. T., Franco, G. L., Soto, N. A. T., Roa, A. A., Curiel, A. M., Torres, E. F. P., & Armadillo, M. D. L. R. (2022) · Acta Universitaria · doi:10.15174/au.2022.3189 · Cited by 4
“Adverse effects are kidney and liver damages, and cardiovascular alterations and increased blood pressure have also been described (Warner & Mitchell, 2008).”
BackgroundPain—novel targets and new technologies
Hua, S., & Cabot, P. J. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00211 · Cited by 4
“Non-steroidal and steroidal anti-inflammatory drugs have serious side effects such as gastric erosions, ulcer formation, bleeding, hypersensitivity reactions, cardiovascular toxicity, renal toxicity, and hepatotoxicity (Warner and Mitchell, 2008; Stein et al., 2009).”
BackgroundDÍAZ-JOUANEN, E., Abud‐Mendoza, C., Garza‐Elizondo, M. A., Medrano-Ramírez, G., Burgos‐Vargas, R., Orozco-Alcalá, J., Pacheco‐Tena, C., Pineda, C., Pozos-Espíndola, J. C., Ramos-Niembro, F., et al. (2009) · PubMed · Cited by 4
Iatrogenic hypertension: a bioinformatic analysis
Botzer, A., Finkelstein, Y., Grossman, E., Moult, J., & Unger, R. (2018) · The Pharmacogenomics Journal · doi:10.1038/s41397-018-0062-0 · Cited by 5
MICROPROPAGATION AND MEDICINAL PROPERTIES OF BARLERIA GREENII AND HUERNIA HYSTRIX
Amoo, S. O. (2009) · ResearchSpace (University of KwaZulu-Natal) · Cited by 4
Lakota, K., Hrušovar, D., Ogrič, M., Mrak‐Poljšak, K., Čučnik, S., Tomšič, M., Božič, B., Žigon, P., & Sodin-Semrl, S. (2018) · Mediators of Inflammation · doi:10.1155/2018/8237209 · Cited by 3
“However, different NSAIDs showed differential modes of activity; for example, diclofenac, a derivative of acetic acid, acted similarly to COX-2 selective inhibitors in increasing risk of myocardial infarction (MI) [42], as was the case for all NSAIDs depending on dose administered, as they all inhibit COX-2 enzyme act…”
BackgroundNon-steroidal anti-inflammatory drugs and increased risk of sudden cardiac death
Hwang, S. M., Gilda, J. E., Cui, Z., & Gomes, A. V. (2013) · Cited by 3
Dell’Isola, A., Kiadaliri, A., Hellberg, C., Turkiewicz, A., & Englund, M. (2023) · Clinical Epidemiology · doi:10.2147/clep.s401726 · Cited by 2
“This trend can be the result of the growing attention around the safety of NSAIDs for the treatment of chronic painful conditions such as OA or could result from more patients entering the intervention at an earlier stage of the disease.(25) Nearly 7% of the sample (7632 individuals) reported not using NSAIDs for the…”
ResultComment utiliser les antalgiques non opiacés en postopératoire ?
Beloeil, H. (2015) · La Presse Médicale · doi:10.1016/j.lpm.2014.09.026 · Cited by 2
“tome xx > n8x > xx 2015 COX-1 qui différencie les AINS-T et les ISCOX-2 [18].”
BackgroundPolypharmacology in Clinical Applications—Anti-inflammation Polypharmacology
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BackgroundShaheen, H. M., & El-Sheikh, M. W. (2011) · Kafrelsheikh Veterinary Medical Journal · doi:10.21608/kvmj.2011.113534 · Cited by 1
“All nonsteroidal antiinflammatory drugs (NSAIDs) in doses adequate to reduce inflammation and pain can increase blood pressure in both normotensive and hypertensive individuals (Warner & Mitchell 2008).”
BackgroundBeltag, D., Ali, E. M. M., Sakr, H., & Radwan, E. (2022) · Journal of Medical and Life Science · doi:10.21608/jmals.2022.273349 · Cited by 1
Bellien, J. (2020) · Elsevier eBooks · doi:10.1016/b978-2-294-76697-8.00001-6 · Cited by 1
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de Vries, H. R. (2008) · Medisch-Farmaceutische Mededelingen · doi:10.1007/bf03077070 · Cited by 1
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“In terms of cardiovascular complications the risk profile is not correlated to the specificity of COX-inhibition [8].”
BackgroundThe Prescription and Drug Names
Weinberg, M. A., & Froum, S. J. (2012) · doi:10.1002/9781118704721.ch2
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“Though COX-2selective drugs inherently cause different cardiovascular side effects but cardiovascular side-effects are dose-dependent (Warner and Mitchell, 2008).”
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“[6] Warner TD, Mitchell JA.”
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Metadata
- Authors
- Warner, T. D., & Mitchell, J. A.
- Affiliations
- Queen Mary University of London (GB)
- Royal Brompton Hospital (GB)
- Corresponding author
- Warner, Timothy D
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 371
- Issue
- 9608
- Pages
- 270-273
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2164162242
- Cited by
- 166
- References
- 22
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 7 · 2021: 8 · 2020: 8 · 2019: 4 · 2018: 10 · 2017: 8 · 2016: 8 · 2015: 7 · 2014: 12 · 2013: 9 · 2012: 16
- FWCI
- 13.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Antiplatelet Therapy and Cardiovascular Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- COX-2 selectivity, nonsteroidal anti-inflammatory drugs, cardiovascular risk, thrombosis risk, gastrointestinal risk, cyclooxygenase inhibition, cyclooxygenase-1, cyclooxygenase-2, etoricoxib, rofecoxib, celecoxib, lumiracoxib, drug safety, cardiovascular adverse events, gastrointestinal adverse effects, American Heart Association guidelines
- MeSH terms
- Anti-Inflammatory Agents, Non-Steroidal, Dose-Response Relationship, Drug, Gastrointestinal Diseases, Humans, Myocardial Infarction, Risk Factors, Thrombosis, Cyclooxygenase 2 Inhibitors
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