Cited by 823Genetic Associations and EpidemiologyAtherosclerosis and Cardiovascular DiseasesAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 46 of the 47 references it cites were found in a registry or an index.

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

Open access

‡·2012·The Lancet

DOI 10.1016/s0140-6736(11)61931-4PMC PMC3316940

Open this paper in CoChat — free account Open PDF

Abstract

Background Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To assess whether this pathway is causally relevant to coronary heart disease, we studied a functional genetic variant known to affect IL6R signalling.Methods In a collaborative meta-analysis, we studied Asp358Ala (rs2228145) in IL6R in relation to a panel of conventional risk factors and inflammation biomarkers in 125,222 participants. We also compared the frequency of Asp358Ala in 51,441 patients with coronary heart disease and in 136,226 controls. To gain insight into possible mechanisms, we assessed Asp358Ala in relation to localised gene expression and to postlipopolysaccharide stimulation of interleukin 6.Findings The minor allele frequency of Asp358Ala was 39%. Asp358Ala was not associated with lipid concentrations, blood pressure, adiposity, dysglycaemia, or smoking (p value for association per minor allele ≥0·04 for each). By contrast, for every copy of 358Ala inherited, mean concentration of IL6R increased by 34·3% (95% CI 30·4-38·2) and of interleukin 6 by 14·6% (10·7-18·4), and mean concentration of C-reactive protein was reduced by 7·5% (5·9-9·1) and of fibrinogen by 1·0% (0·7-1·3). For every copy of 358Ala inherited, risk of coronary heart disease was reduced by 3·4% (1·8-5·0). Asp358Ala was not related to IL6R mRNA levels or interleukin-6 production in monocytes.Interpretation Large-scale human genetic and biomarker data are consistent with a causal association between IL6R-related pathways and coronary heart disease.Funding British Heart Foundation; UK Medical Research Council; UK National Institute of Health Research, Cambridge Biomedical Research Centre; BUPA Foundation.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/s0140-6736(11)61931-4

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139
Progress and challenges in translating the biology of atherosclerosis
Libby, P., Ridker, P. M., & Hansson, G. K. (2011) · Nature · doi:10.1038/nature10146 · Cited by 4,010
Rheumatoid arthritis
Scott, D. L., Wolfe, F., & Huizinga, T. W. J. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60826-4 · Cited by 3,263
C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis
(2010) · The Lancet · doi:10.1016/s0140-6736(09)61717-7 · Cited by 2,546
Plasma Concentration of Interleukin-6 and the Risk of Future Myocardial Infarction Among Apparently Healthy Men
Ridker, P. M., Rifai, N., Stampfer, M. J., & Hennekens, C. H. (2000) · Circulation · doi:10.1161/01.cir.101.15.1767 · Cited by 2,429
The immune system in atherosclerosis
Hansson, G. K., & Hermansson, A. (2011) · Nature Immunology · doi:10.1038/ni.2001 · Cited by 2,389
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Cardiogenics, Schunkert, H., the CARDIoGRAM Consortium, König, I. R., Kathiresan, S., Reilly, M. P., Assimes, T. L., Holm, H., Preuss, M., Stewart, A. F. R., et al. (2011) · Nature Genetics · doi:10.1038/ng.784 · Cited by 1,866
Plasma Fibrinogen Level and the Risk of Major Cardiovascular Diseases and Nonvascular Mortality
Danesh, J., Lewington, S., Thompson, S. G., Lowe, G. D. O., Collins, R., Kostis, J. B., Wilson, A. C., Folsom, A. R., Wu, K., Benderly, M., et al. (2005) · JAMA · doi:10.1001/jama.294.14.1799 · Cited by 1,162
Population genomics of human gene expression
Stranger, B. E., Nica, A. C., Forrest, M. S., Dimas, A. S., Bird, C., Beazley, C., Ingle, C., Dunning, M., Flicek, P., Koller, D., et al. (2007) · Nature Genetics · doi:10.1038/ng2142 · Cited by 1,153
Genomics, type 2 diabetes, and obesity
McCarthy, M. I. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0906948 · Cited by 938

Show all 47 references

Research works printed but not linked: 2

Lamas, 2011, Mechanisms underlying the generation of soluble IL-6 soluble receptor (sIL-6R) in rheumatoid arthritis: mRNA alternative splicing and proteolytic cleavage as independent contributors, Arthritis Rheum, 63, 383
Genovese, 2009, Analysis of low-density lipoprotein and adverse events in rheumatoid arthritis patients treated with tocilizumab plus statins: data from five phase III clinical trials, Rheumatology (Oxford), 48, I81

Sorted by citations

Items 701–800 of 823

Changes in serum lipids in patients with rheumatoid arthritis treated with a combination of tocilizumab and methotrexate compared with methotrexate alone for 24 weeks of observation
Udachkina, E. V., Novikova, D. S., Попкова, Т. В., Panasyuk, E. Y., Avdeeva, A. S., Volkov, A. V., Геннадьевна, К. И., Markelova, E. I., Aleksandrova, E. N., Novikov, A. A., et al. (2015) · Rational Pharmacotherapy in Cardiology · doi:10.20996/1819-6446-2015-11-5-510-516 · Cited by 1
Role of Conventional Risk Factors in Genetic Susceptibility to Cardiovascular Diseases
Swerdlow, D. I., Michail, M., & Zacharias, K. A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803312-8.00008-2 · Cited by 2
OTU-007 Treating ileocolonic crohn’s strictures with removable-sems – efficacy and safety, a large single centre experience
Das, R., Singh, R., Din, S., Chilkunda, D., Krishnamoorthy, R., Fraser, C. C., Williams, J. L., Goddard, A. F., Norton, B., Hearing, S. D., et al. (2018) · doi:10.1136/gutjnl-2018-bsgabstracts.110 · Cited by 1
Cardiac Immunomodulation
Könemann, S., Dörr, M., & Felix, S. B. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803267-1.00028-4 · Cited by 2
Inflammatory cardiovascular risk markers and silent myocardial ischemia in type 2 diabetic patients
Malešević, G., Popović‐Pejičić, S., Marković, A., & Stanković, V. S. (2021) · Vojnosanitetski pregled · doi:10.2298/vsp201012010m · Cited by 1
Tumor Necrosis Factor-Alpha and Interleukin-4 Levels in Patients With Idiopathic Sudden Sensorineural Hearing Loss
Kim, A. Y., Kim, S., Choi, S.-Y., Moon, J. W., Choi, J., Im, G. J., Chae, S.-W., & Song, J. (2021) · Korean Journal of Otorhinolaryngology - Head and Neck Surgery · doi:10.3342/kjorl-hns.2021.00059 · Cited by 1
The Use of Ultrasound for Detecting the Association Between Endothelial Dysfunction and lp13.3 Genomic Region rs646776 Polymorphism in Patients With Rheumatoid Arthritis From the Suez Canal Region
Ahmed, A. H., Omar, A. S., Ghattas, M. H., Ghaly, M. S., & Al-Shatouri, M. A. (2023) · Cureus · doi:10.7759/cureus.34743 · Cited by 1
IL6R Gene Polymorphisms and Their Relation to Chronic Obstructive Pulmonary Disease Susceptibility in the Chinese Population
Wu, H., He, C., Fu, Y., Li, X., Zheng, Y., Mo, R., Zhang, L., Zhao, J., Zhang, B., Lin, Q., et al. (2022) · Biomarkers in Medicine · doi:10.2217/bmm-2022-0342 · Cited by 1
Endothelial Dysfunction in Type 2 Diabetes with an Update on New Interventions
Ward, N. C., Loh, W. J., & Watts, G. F. (2023) · Contemporary diabetes · doi:10.1007/978-3-031-26681-2_14 · Cited by 2
What is Surveillance teaching us (and what it is not?)
Buch, M. H. (2023) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2023.152334 · Cited by 1
Impact of IL-6 and IL-6r variants on HIV-1 susceptibility and progression to AIDS: a case-control study in a Moroccan population
Haddaji, A., Ouladlahsen, A., Lkhider, M., Tanouti, I., Abbadi, I., Hilmi, S., Bensghir, R., Guessous, F., Pineau, P., Filali, K. M. E., et al. (2024) · Nucleosides Nucleotides & Nucleic Acids · doi:10.1080/15257770.2024.2359593 · Cited by 1
CARDIOVACULAR COMORBIDITY IN PATIENTS WITH PSORIASIS
Газизовна, М. Э., Марсельевна, А. Р., Sterlitamak Physician at the Hippocrates, M. C., Khismatullina, Z. R., Эльдусовна, Н. А., Рамилевна, Г. В., ASADULLINA, G. V., Искандаровна, С. Л., Искандаровна, С. Л., RUSTYAMOVA, Z. Y., et al. (2024) · The Bulletin of Contemporary Clinical Medicine · doi:10.20969/vskm.2024.17(3).67-72 · Cited by 1
Severe bronchiectasis is associated with increased carotid intima-media thickness
Kwok, W. C., Lau, K. K., Teo, K. C., Leung, I. S. H., Tsui, C. K., Hsu, M. S. S., Pijarnvanit, T. K. K. T. S., Cheung, C. N.-M., Chow, Y. H., & Ho, J. (2024) · BMC Cardiovascular Disorders · doi:10.1186/s12872-024-04129-x · Cited by 1
Interactions of genetic and non-genetic factors on plasma hs-CRP concentration in a Korean community-based cohort study
Hong, E. P., Kim, D.-H., & Park, J. W. (2014) · Genes & Genomics · doi:10.1007/s13258-014-0240-7 · Cited by 1
Coronary artery disease and myocardial infarction
(2011) · Oxford University Press eBooks · doi:10.1093/med/9780199559688.003.0130 · Cited by 1
Association between soluble biomarkers - microbial translocation, inflammation and cardiovascular risk in HIV- infected individuals: a systematic review
Borato, D. C. K., & Vellosa, J. C. R. (2020) · Brazilian Journal of Pharmaceutical Sciences · doi:10.1590/s2175-97902019000318567 · Cited by 1
Lipoprotein(a): A Cardiovascular Risk Factor Affecting Ethnic Minorities
Nelson, R. R., Watson, K. E., & Reyes‐Soffer, G. (2021) · Contemporary cardiology · doi:10.1007/978-3-030-81034-4_3 · Cited by 1
Spontaneous Preterm Labor and Cardiovascular Disease Risk: One Step Closer to a Better Understanding
Kuklina, E. V., & Shilkrut, A. G. (2012) · Journal of Women s Health · doi:10.1089/jwh.2012.3678 · Cited by 1
Mendelian randomization for investigating causal roles of biomarkers in multifactorial health outcomes: a lesson from studies on liver biomarkers
Abbasi, A. (2017) · International Journal of Epidemiology · doi:10.1093/ije/dyx063 · Cited by 1
Bringing interleukin-6 complexity to preventive cardiology practice?
Santos, R. D., & Rocha, V. Z. (2019) · European Journal of Preventive Cardiology · doi:10.1177/2047487319876765 · Cited by 1
Genetic instrument selection for Mendelian randomization explorations of drug target effects
Georgakis, M. K. (2020) · International Journal of Epidemiology · doi:10.1093/ije/dyaa060 · Cited by 1
Kuopio Ischemic Heart Disease Risk Factor Study
Jussi, K. (2016) · Springer eBooks · doi:10.1007/978-1-4614-6439-6_328-2 · Cited by 1
An atlas of genetic effects on the monocyte methylome across European and African populationsPreprint
Zhang, W.-H., Zhang, X., Qiu, C., Zhang, Z.-C., Su, K.-J., Luo, Z., Liu, M., Zhao, B.-X., Wu, L., Tian, Q., et al. (2024) · medRxiv · doi:10.1101/2024.08.12.24311885 · Cited by 1
Dissecting Regulatory Non-Coding Heart Disease GWAS Loci with High-Resolution 3D Chromatin Interactions Reveals Causal Genes with Pathophysiological Relevance to Heart FailurePreprint
Gill, R., Lu, D., Eres, I. E., Lu, J., Cui, J., Yu, Z., Yamawaki, T., Zhou, H., Pei, B., Amrute, J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.08.617295 · Cited by 1
A framework for studying multi-omic risk factors and their interplay: application to coronary artery diseasePreprint
Hu, J., Lin, C., Zhao, H., & DeWan, A. T. (2025) · medRxiv · doi:10.1101/2025.04.01.25324976 · Cited by 2
Human monocyte subsets in coronary artery disease and myocardial infarction
Tapp, L. D. (2014) · University of Birmingham Institutional Research Archive (University of Birmingham) · Cited by 1
Bayesian Modeling for Environmental Association and Gene-Environment Interaction Under Complex Epidemiologic Study Designs.
Li, S. (2013) · Deep Blue (University of Michigan)
Anti-cytokine Agents to Combat Oxidative Stress
Hirao, M., Hashimoto, J., & Nishimoto, N. (2012) · Springer eBooks · doi:10.1007/978-1-4614-6166-1_16
Adipose tissue and arterial changes in young children
Evelein, A. M. V. (2013) · Utrecht University Repository (Utrecht University)
The Direct Program: A Disease/Inflammatory vs Risk Factor Evaluation Cardiovascular Testing Program
Doneen, A. L. (2014) · International Journal of Nursing & Clinical Practices · doi:10.15344/2394-4978/2014/107
Genetics of inflammatory mediators, in particular interleukin 6 and selenoprotein S, that have a role in coronary artery disease.
AlHomidani, H. H. (2015) · Surrey Research Insight Open Access (The University of Surrey)
Human clinical hemorheological investigations in the field of cardiac rehabilitation, renal transplantation and pharmacological innovation
Sándor, B., & Szabados, E. (2014)
From THE INSTITUTE OF ENVIRONMENTAL MEDICINE
Giuseppe, D. D. (2014)
Learning from anomalies: the case of cholesterol and ischaemic heart disease
Schooling, C. M., & Leung, G. M. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyv308
Die Rolle von Pentraxin 3 und Interleukin-6-Transsignaling im Rahmen des Polytraumas
Becker, C. A. (2015) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-11037
Regulation of Anti-Inflammatory Gene Expression in Vascular Endothelial Cells by EPAC1
Palmer, T. M., & Yarwood, S. J. (2016) · Journal of Cell Signaling · doi:10.4172/2576-1471.1000103
Perfil de mediadores inflamatórios no processo aterosclerótico carotídeo
da Silva, W. M. (2015) · doi:10.26512/2015.07.d.19259
Biosciences: Replication of Methods Sections
Zhang, Y.-H. H. (2015) · Qualitative and quantitative analysis of scientific and scholarly communication · doi:10.1007/978-3-319-24160-9_5
Preclinical atherosclerosis in rheumatoid arthritis
O’Sullivan, M. (2014) · Arrow@dit (Dublin Institute of Technology)
Meta-analysis on the Role of High-sensitivity C-reactive Protein Monitoring in Relation to the Presence of Glucose Intolerance in Patients Treated with HMG-CoA Reductase Inhibitors
Kiribayashi, M., & Echizen, H. (2012) · Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) · doi:10.5649/jjphcs.38.479
Inflammatory Disease
Ishizuka, T., Fukuzawa, Y., Nagasaka, M., Tanigawa, T., Shichi, D., Morita, H., & Hiramatsu, N. (2014) · Nihon Naika Gakkai Zasshi · doi:10.2169/naika.103.1195
The Biology of Interleukin-6, a Major Target in Anti-Inflammatory Therapies
Chalaris, A., Rose‐John, S., & Garbers, C. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-374279-7.10004-9
Particularities of cardiovascular patterns related to rheumatic disease from biological findings to clinical aspects
Stoia, M. A. (2015) · Balneo Research Journal · doi:10.12680/balneo.2015.1109
Immune-Mediated Accelerated Atherosclerosis
Gruber, S., Tsiantoulas, D., & Binder, C. J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803267-1.00004-1
Association between genetically elevated levels of inflammatory biomarkers and risk of schizophrenia: a two-sample Mendelian randomisation studyPreprint
Hartwig, F. P., Borges, M. C., Horta, B. L., Bowden, J., & Smith, G. D. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/123976
16. The role of dietary saturated fatty acids in cardiovascular disease
Vissers, L. E. T., Sluijs, I., & van der Schouw, Y. T. (2017) · Wageningen Academic Publishers eBooks · doi:10.3920/978-90-8686-853-7_16
The burden of myocardial infarction
Hartman, H. (2017) · University of Groningen research database (University of Groningen / Centre for Information Technology)
Induced carotid atherosclerosis in lupus mice
Wang, Y., Huang, Z., Lin, L., Huang, G., Liu, W., & Xue, Y. (2018) · Clinical and Experimental Hypertension · doi:10.1080/10641963.2018.1510943
Relationship of Interleukin-6 Trans-Signaling and Coronary Heart Disease in Young Adults: a Case-Control Study in Indonesia
Sinardja, J., Darwin, E., Decroli, E., & Tjong, D. H. (2019) · Biomedical & Pharmacology Journal · doi:10.13005/bpj/1675
Aspects of carbohydrate quality and their relevance for risk markers of type 2 diabetes and related health outcomes
Goletzke, J. (2014) · bonndoc (University of Bonn)
Cardiovascular effects of metformin on left ventricular hypertrophy in nondiabetic patients with coronary artery disease
Mohan, M. (2019) · Discovery Research Portal (University of Dundee)
Individualized prevention in cardiovascular disease and diabetes mellitus
de Vries, T. I. (2020) · doi:10.33540/352
Inflammatory biomarkers in ischemic heart disease
Groot, H. E. (2021) · University of Groningen research database (University of Groningen / Centre for Information Technology) · doi:10.33612/diss.156111034
IL-6R Protective Variant rs7529229 Reduces Interleukin-6 Signaling and Contributes To A Decreased Ischemic Stroke RiskPreprint
Zhang, H., Zhao, W., Liu, B., Wang, T., Han, Z., Ji, X., & Liu, G. (2020) · doi:10.21203/rs.3.rs-93821/v1 · Cited by 1
Polymorphisms and Gene-Gene Interaction in AGER/IL6 Pathway are Associated with Diabetic Ischemic Heart DiseasePreprint
Liu, K., Xie, Y., Zhao, Q., Peng, W., Guo, C., Zhang, J., & Zhang, L. (2021) · Research Square · doi:10.21203/rs.3.rs-147920/v1
Supplemental and dietary calcium intakes in postmenopausal women: a series of studies on vascular and bone health
Ong, A. M. (2020) · eScholarship@McGill (McGill) · doi:10.82308/54884
Interleukin-6
Rose‐John, S. (2021) · Springer eBooks · doi:10.1007/978-3-030-57401-7_10025
References
(2018) · Wiley eBooks · doi:10.1002/9781118829875.refs
Mannose-binding lectin reduces oxidized low-density lipoprotein induced vascular endothelial cells injury by modulating autophagy via LOX1Preprint
Zhou, X. J., Chen, X.-F., Zhang, L., Yuan, J., Hu, L., Zhu, M., Xu, X., Dong, G., Fu, J., & Wu, W. (2021) · Research Square · doi:10.21203/rs.3.rs-238411/v1
Biomarkers of Cardiovascular Disorders
Jain, K. K. (2017) · Springer eBooks · doi:10.1007/978-1-4939-7431-3_15
Interleukin-6
Rose‐John, S. (2020) · Springer eBooks · doi:10.1007/978-3-030-21573-6_10025-1
Pathway analysis identifies novel non-synonymous variants contributing to extreme vascular outcomes in Williams-Beuren syndromePreprint
Liu, D., Billington, C. J., Raja, N., Wong, Z. C., Levin, M. D., Resch, W., Alba, C., Hupalo, D. N., Biamino, E., Bedeschi, M. F., et al. (2022) · medRxiv · doi:10.1101/2022.09.21.22280107
Inflammatory Activity in Patients with Obstructive and Non-obstructive Coronary Artery Disease
Pakhtusov, N. N., Yusupova, A. O., Лишута, А. С., Slepova, O. A., Privalova, E. V., & Belenkov, Y. N. (2023) · Rational Pharmacotherapy in Cardiology · doi:10.20996/1819-6446-2023-01-09
Data from Phase II Study of Personalized Peptide Vaccination for Previously Treated Advanced Colorectal Cancer
Kibe, S., Yutani, S., Motoyama, S., Nomura, T., Tanaka, N., Kawahara, A., Yamaguchi, T., Matsueda, S., Komatsu, N., Miura, M., et al. (2023) · doi:10.1158/2326-6066.c.6548051.v1
Artritis reumatoide y riesgo cardiovascular
Karsulovic, C., Julia Guerrero, P., & Annelise Goecke, S. (2019) · Revista Hospital Clínico Universidad de Chile · doi:10.5354/2735-7996.2019.70244
Pharmaceutical Importance of Components of Tea in Preventing Cardiovascular Diseases (CVDs), Pathways and Genes Involved in CVDs and Strategy to Enhance the Absorption of Tea Components by Human Body
1 Individual Researcher, J., Borthakur, D., Shu, Z., Dutta, A., Liang, Y., Mukhopadhyay, R., & He, W. (2023) · Biomedical and Translational Science · doi:10.33425/2768-4911.1043
Interleukin-6 and its role in SARS-COV-2 induced myocardial injury
Zhang, Z. (2024) · International Conference on Biological Engineering and Medical Science (ICBioMed) · doi:10.1117/12.3012994
A bibliometric analysis of research hotspots and cutting-edge trends in cardiovascular disease biomarkersPreprint
Sun, X., Wu, X., Wu, T., & Xie, X. (2024) · Research Square · doi:10.21203/rs.3.rs-3991146/v1
The Mechanism of Inflamm-Aging in Elderly Frailty Syndrome
叶赛·艾尼瓦尔, 米. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.143869
Heterogeneous associations between interleukin-6 receptor variants and phenotypes across ancestries and implications for therapy
Wang, X., Liu, M., Nogues, I.-E., Chen, T., Xiong, X., Bonzel, C.-L., Zhang, H. G., Hong, C., Yin, X., Dahal, K. P., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-54063-3 · Cited by 2
Evolving Targets of Therapy
Ridker, P. M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-28786-9.00031-1
A comprehensive retrospect on biomarkers indicating vascular failure
Sakuma, M., Masaki, N., Yano, S., Shimabukuro, M., Yamaoka‐Tojo, M., Fukuda, D., Hironori Nakagami, A., Node, K., & Sata, M. (2024) · Vascular Failure · doi:10.30548/vascfail.8.1_24
The Biology of Interleukin-6: A Major Target in Anti-Inflammatory Therapies
Rose‐John, S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-128-24465-4.00103-4
Clinical observation of Danlou tablets combined with aspirin for phlegm and blood stasis syndrome in coronary heart disease: impact on related serum factors
Sun, L. (2024) · American Journal of Translational Research · doi:10.62347/wmbn8994
Inflammation in the Peri-ACS Period: Ready for Prime Time?
Rao, S. V., & Lerner, J. B.-A. (2024) · Current Atherosclerosis Reports · doi:10.1007/s11883-024-01263-x
Pseudo- p -Value-Based Clumping Enhanced Proteome-wide Mendelian Randomization with Application in Identifying Coronary Heart Disease-Associated Plasma ProteinsPreprint
Wang, Y., Cao, Y., Chen, D., Shi, D., Fu, L., Chen, A., Shen, S., & Hu, Y. (2025) · medRxiv · doi:10.1101/2025.01.13.25320450
THE CLINICAL RELEVANCE OF INTERLEUKIN 6 & hs-CRP IN CARDIOVASCULAR DISEASES: A CASE STUDY.
Kumar, R., Kumar, R., Shilpa, S., Kumar, S., Kumar, S. T., Muni, S., & Kumari, N. (2025) · Student s Journal of Health Research Africa · doi:10.51168/sjhrafrica.v6i3.1645
Coronary artery disease and human immunodeficiency virus
Sharma, T., Sharma, B., Chaudhary, R., Faraday, N. R., & Goldsweig, A. M. (2025) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2025.103101
Reply to: Residual cardiovascular risk in CKD: Reaffirming the role of remnant cholesterol and inflammation
Elías-López, D., Kobylecki, C. J., Vedel‐Krogh, S., Doi, T., & Nordestgaard, B. G. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2025.120450
Examining whether inflammation mediates effects of genetic risk and trauma on psychopathology
Lilford, P., Hammerton, G., Khandaker, G. M., Hall, J., Zammit, S., & Jones, H. J. (2025) · BJPsych Open · doi:10.1192/bjo.2025.10054
Revisiting the Role of Interleukin-6 in Predicting Stroke and Cardiovascular Events
Miwa, K. (2025) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.ed288
Cardiovascular disease in women: do we focus on single jigsaw pieces or look at the whole puzzle?
Krasner, S., Li, M., & Leeson, P. (2025) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwaf620
Towards defining endotype-specific mechanisms of sub-clinical atherosclerosis to advance precision medicine for cardiovascular disease
Tarkin, J. M., & Butterworth, A. S. (2025) · Cardiovascular Research · doi:10.1093/cvr/cvaf244
Additional file 2 of Severe bronchiectasis is associated with increased carotid intima-media thickness
Kwok, W. C., Lau, K. K., Teo, K. C., Leung, S. H. I., Tsui, C. K., Hsu, M. S. S., Pijarnvanit, T. K. K. T. S., Cheung, C. N.-M., Chow, Y. H., & Ho, J. C. M. (2024) · Figshare · doi:10.6084/m9.figshare.26943603
Additional file 2 of An epithelial gene signature of trans-IL-6 signaling defines a subgroup of type 2-low asthma
El-Husseini, Z. W., Khalenkow, D., Lan, A., van der Molen, T., Brightling, C., Papi, A., Rabe, K. F., Siddiqui, S., Singh, D., Kraft, M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26651094
Additional file 1 of Severe bronchiectasis is associated with increased carotid intima-media thickness
Kwok, W. C., Lau, K. K., Teo, K. C., Leung, S. H. I., Tsui, C. K., Hsu, M. S. S., Pijarnvanit, T. K. K. T. S., Cheung, C. N.-M., Chow, Y. H., & Ho, J. C. M. (2024) · Figshare · doi:10.6084/m9.figshare.26943600
Additional file 1 of An epithelial gene signature of trans-IL-6 signaling defines a subgroup of type 2-low asthma
El-Husseini, Z. W., Khalenkow, D., Lan, A., van der Molen, T., Brightling, C., Papi, A., Rabe, K. F., Siddiqui, S., Singh, D., Kraft, M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26651091
Additional file 1 of Proteomic insights into the associations between obesity, lifestyle factors, and coronary artery disease
Yang, F., Xu, F., Zhang, H., Gill, D., Larsson, S. C., Li, X., Cui, H., & Yuan, S. (2023) · Figshare · doi:10.6084/m9.figshare.24741992
Additional file 2 of Proteomic insights into the associations between obesity, lifestyle factors, and coronary artery disease
Yang, F., Xu, F., Zhang, H., Gill, D., Larsson, S. C., Li, X., Cui, H., & Yuan, S. (2024) · Figshare · doi:10.6084/m9.figshare.24742994
Inflammation in pathogenesis of cardiovascular diseases and prospects for targeted anti-inflammatory therapy
Каминный, А. И., Shuvalova, Y. A., Kaminnaya, V. I., & Палеев, Ф. Н. (2025) · Russian Cardiology Bulletin · doi:10.17116/cardiobulletin2025200415
Association and Predictive Value of C-Reactive Protein-Lymphocyte-Albumin (CALLY) Index with Cardiovascular Disease in Patients with Cardiovascular–Kidney–Metabolic Syndrome Stage 3
Yuan, M., Li, L., Hou, Y., Wei, L., Zhang, R., & Jiang, H. (2026) · International Journal of General Medicine · doi:10.2147/ijgm.s576278
The impact of IL-6R gene polymorphism (rs8192284) on type 2 diabetes mellitus and other metabolic disorders in the Bangladeshi population
Kabir, A., Khan, M. A. A. M., & Kibria, K. M. K. (2026) · Human Gene · doi:10.1016/j.humgen.2026.201536
The shared genetic architecture underlying the autoimmune and cardiovascular disease: a multivariate genome-wide analysis
Zhang, J., Fang, X., Ye, Q., Yin, X., & Dongqing, Y. E. (2026) · Cardiovascular Diabetology · doi:10.1186/s12933-025-03041-8 · Cited by 2
Circulating type I collagen pro-α1 chain is inversely associated with the presence of coronary atherosclerosis in a Swedish middle-aged population
Hammaréus, F., Nilsson, L., Chung, R. W. S., Nyström, F. H., Östgren, C. J., & Jonasson, L. (2026) · Scientific Reports · doi:10.1038/s41598-026-45736-2
Cerebrovascular integrity maintenance and inflammation in atherosclerosis animal models
Cataldo, V. D. (2016) · theses.fr (ABES) · doi:10.70675/7b5a6c4bz3377z40fezbf48z5da7afd1a502
Rôle des macrophages au cours de l'infection par le VIH-1 et dans un contexte de co-infection avec Mycobacterium tuberculosis
Souriant, S. (2017) · theses.fr (ABES) · doi:10.70675/1508e6c1zc271z49c7z80eez7d9af58ba3f5
Impact des mutations du gène TET2 sur le développement et les fonctions lymphocytaires Natural Killer
Zhao, L. (2023) · theses.fr (ABES) · doi:10.70675/2366151bzc9afz43c1z8762z323b710bebbc
A Systematic Review of the Prognostic Value of Inflammatory Biomarkers in Outcomes After Endovascular Abdominal Aortic Aneurysm Repair
Koudounas, G., Lomvardeas, O., Kalogirou, T. E., Moulakakis, K. G., Papazoglou, K. O., & Karkos, C. D. (2026) · Angiology · doi:10.1177/00033197261448369
Pharmacogenetic Analysis of Variants in IL-6 Signaling and Response to Modern Therapeutic Approaches in Greek Patients with Atopic Dermatitis
Triantafillidi, D., Tziouvara, V., Pontikas, A., Akritidis, A., Antonatos, C., Zacharopoulou, A., Tsiogka, A., Kleidona, I. A., Grafanaki, K., Chrysospathi, A., et al. (2026) · Genes · doi:10.3390/genes17050575
Can markers predict plaque vulnerability?
Acoba, D., & Gonçalves, I. (2026) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2026.120744

Authors: ‡
Affiliations: University of Cambridge (GB)
Corresponding author: ‡
Venue: The Lancet
Publisher: Elsevier BV
Published: 2012-03
Volume: 379
Issue: 9822
Pages: 1205-1213
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(11)61931-4
PMC: PMC3316940
OpenAlex: W2139957955
Cited by: 823
References: 47
Citations by year: 2026: 48 · 2025: 46 · 2024: 63 · 2023: 46 · 2022: 50 · 2021: 69 · 2020: 73 · 2019: 57 · 2018: 61 · 2017: 60 · 2016: 58 · 2015: 48 · 2014: 72 · 2013: 48 · 2012: 23
FWCI: 7.54
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: The Lancet (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
UWA Profiles and Research Repository (UWA) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
UCL Discovery (University College London) (submittedVersion)
Figshare (submittedVersion, cc-by)
ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
UnissResearch (Università degli Studi di Sassari) (submittedVersion)
Leicester Research Archive (University of Leicester) (submittedVersion, other-oa)
Lund University Publications (Lund University) (submittedVersion)
mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
Site cant be reached (submittedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Bristol Research (University of Bristol) (submittedVersion)
STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
Funders: British Heart Foundation (RG/08/014)
Bupa Foundation
Medical Research Council
NIHR Cambridge Biomedical Research Centre
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: IL-6 receptor, coronary artery disease, rs2228145, genetic association, inflammation, C-reactive protein, fibrinogen, interleukin-6, chronic inflammation, cardiovascular risk factors, monocytes, gene expression
MeSH terms: Coronary Disease, Gene Frequency, Humans, Risk Factors, Genetic Variation, Signal Transduction, Causality, Inflammation Mediators, Receptors, Interleukin-6

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks