Averting a malaria disaster: will insecticide resistance derail malaria control?
Open accessAbstract
World Malaria Day 2015 highlighted the progress made in the development of new methods of prevention (vaccines and insecticides) and treatment (single dose drugs) of the disease. However, increasing drug and insecticide resistance threatens the successes made with existing methods. Insecticide resistance has decreased the efficacy of the most commonly used insecticide class of pyrethroids. This decreased efficacy has increased mosquito survival, which is a prelude to rising incidence of malaria and fatalities. Despite intensive research efforts, new insecticides will not reach the market for at least 5 years. Elimination of malaria is not possible without effective mosquito control. Therefore, to combat the threat of resistance, key stakeholders need to rapidly embrace a multifaceted approach including a reduction in the cost of bringing new resistance management methods to market and the streamlining of associated development, policy, and implementation pathways to counter this looming public health catastrophe.
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Increasing levels of insecticide resistance threaten to undermine existing vector control methods.
“While previous successful disease eradication programmes for smallpox and rinderpest relied heavily on vaccination, there remains no highly effective licensed vaccine for malaria and increasing levels of insecticide resistance threaten to undermine existing vector control methods [9].”
From Achieving global malaria eradication in changing landscapes (2021) · cites this paper as [9]
There remains no highly effective licensed vaccine for malaria.
“While previous successful disease eradication programmes for smallpox and rinderpest relied heavily on vaccination, there remains no highly effective licensed vaccine for malaria and increasing levels of insecticide resistance threaten to undermine existing vector control methods [9].”
From Achieving global malaria eradication in changing landscapes (2021) · cites this paper as [9]
The Introduction refers to a “future vaccine roll-out,” and the Abstract mentions progress in vaccine development. Neither passage states whether a highly effective malaria vaccine was licensed. Searches for “licensed vaccine malaria efficacy highly effective” and “vaccine” found no passage that settles the claim. (LLM, conf=0.72)
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References 17 · Cited by 562
- Authors
- Hemingway, J., Ranson, H., Magill, A., Kolaczinski, J., Fornadel, C., Gimnig, J., Coetzee, M., Simard, F., Roch, D. K., Hinzoumbe, C. K., Pickett, J., Schellenberg, D., Gething, P., Hoppé, M., & Hamon, N.
- Affiliations
- Liverpool School of Tropical Medicine (GB)
- Gates Foundation (US)
- Global Fund to Fight AIDS, Tuberculosis and Malaria (CH)
- United States Agency for International Development (US)
- Centers for Disease Control and Prevention (US)
- University of the Witwatersrand (ZA)
- Chad National Malaria Control Programme (TD)
- Rothamsted Research (GB)
- University of Oxford (GB)
- London School of Hygiene & Tropical Medicine (GB)
- Innovative Vector Control Consortium (GB)
- Corresponding author
- Hemingway, Janet
- ORCID
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 387
- Issue
- 10029
- Pages
- 1785-1788
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- PMC
- PMC6215693
- OpenAlex
- W2266458160
- Cited by
- 562
- References
- 17
- Citations by year
- 2026: 65 · 2025: 61 · 2024: 68 · 2023: 42 · 2022: 44 · 2021: 59 · 2020: 68 · 2019: 53 · 2018: 45 · 2017: 44 · 2016: 12 · 2015: 1
- FWCI
- 50.91
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Rothamsted Repository (Rothamsted Repository) (submittedVersion)
- HAL (submittedVersion, other-oa)
- LSTM Online Archive (Liverpool School of Tropical Medicine) (submittedVersion, cc-by-nc-nd)
- Rothamsted Repository (Rothamsted Repository) (submittedVersion, cc-by-nc-nd)
- Funders
- University of Oxford
- National Institutes of Health (CC999999)
- Medical Research Council (MR/K00669X/1)
- Biotechnology and Biological Sciences Research Council (BBS/E/C/00005194, BB/J008508/1)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Insect Resistance and Genetics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Insect Pest Control Strategies
- Keywords
- malaria, insecticide resistance, pyrethroid resistance, mosquito control, malaria control, resistance management, malaria elimination, malaria vaccine, antimalarial drugs
- MeSH terms
- Animals, Anopheles, Communicable Disease Control, Humans, Insect Vectors, Insecticide Resistance, Malaria, Mosquito Control, Pyrethrins, Africa South of the Sahara, Insecticide-Treated Bednets
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