Out-of-hospital cardiac arrest: prehospital management
Open accessAbstract
Sudden out-of-hospital cardiac arrest is the most time-critical medical emergency. In the second paper of this Series on out-of-hospital cardiac arrest, we considered important issues in the prehospital management of cardiac arrest. Successful resuscitation relies on a strong chain of survival with the community, dispatch centre, ambulance, and hospital working together. Early cardiopulmonary resuscitation and defibrillation has the greatest impact on survival. If the community response does not restart the heart, resuscitation is continued by emergency medical services' staff. However, the best approaches for airway management and the effectiveness of currently used drug treatments are uncertain. Prognostic factors and rules for termination of resuscitation could guide the duration of a resuscitation attempt and decision to transport to hospital. If return of spontaneous circulation is achieved, the focus of treatment shifts to stabilisation, restoration of normal physiological parameters, and transportation to hospital for ongoing care.
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Increases in DNACPR decisions and especially use of blanket CPR exclusion criteria such as age may introduce selection bias and hamper the generalisability of the research results, as well as their applicability to normal conditions.
“Lastly, increases in DNACPR decisions and especially use of blanket CPR exclusion criteria such as age 87,88,385,390,393 may introduce selection bias and hamper the generalisability of the research results, as well as their applicability to normal conditions.”
From European Resuscitation Council Guidelines 2021: Ethics of resuscitation and end of life decisions (2021) · cites this paper as [393]
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A randomized trial of epinephrine in out-of-hospital cardiac arrest
Perkins, G. D., Ji, C., Deakin, C. D., Quinn, T., Nolan, J. P., Scomparin, C., Regan, S., Long, J., Slowther, A., Pocock, H., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1806842 · Cited by 794 · see citing works
Self-citationEuropean Resuscitation Council Guidelines 2021: Ethics of resuscitation and end of life decisions
Mentzelopoulos, S. D., Couper, K., Voorde, P. V. D., Druwé, P., Blom, M., Perkins, G. D., Lulic, I., Djakow, J., Raffay, V., Lilja, G., et al. (2021) · Resuscitation · doi:10.1016/j.resuscitation.2021.02.017 · Cited by 246 · see citing works
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- Authors
- Ong, M. E. H., Perkins, G. D., & Cariou, A.
- Affiliations
- SingHealth (SG)
- Heart of England NHS Foundation Trust (GB)
- Hôpital Cochin (FR)
- Corresponding author
- Ong, Marcus Eng Hock
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2018-03
- Volume
- 391
- Issue
- 10124
- Pages
- 980-988
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2791873328
- Cited by
- 226
- References
- 0
- Citations by year
- 2026: 15 · 2025: 23 · 2024: 30 · 2023: 28 · 2022: 43 · 2021: 31 · 2020: 32 · 2019: 14 · 2018: 10
- FWCI
- 5.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Warwick Research Archive Portal (University of Warwick) (acceptedVersion)
- Funders
- Deakin University
- Topics
- Health Sciences › Medicine › Emergency Medicine › Cardiac Arrest and Resuscitation
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- out-of-hospital cardiac arrest, prehospital care, cardiopulmonary resuscitation, defibrillation, chain of survival, emergency medical services, community response, airway management, resuscitation drugs, prognostic factors, termination of resuscitation, return of spontaneous circulation, patient stabilization, hospital transport
- MeSH terms
- Electric Countershock, Emergency Medical Services, Humans, Cardiopulmonary Resuscitation, Out-of-Hospital Cardiac Arrest
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