The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Pharmacogenomics
Open accessAbstract
Genomic Medicine, using DNA variation to individualize and improve human health, is the subject of this series of reviews. The idea that genetic variation can be used to individualize drug therapy – the topic addressed here – is often viewed as “low-hanging fruit” for Genomic Medicine. We review general mechanisms underlying variability in drug action, the role of genetic variation in mediating beneficial and adverse effects through variable drug concentrations (pharmacokinetics) and drug actions (pharmacodynamics), available data from clinical trials, and ongoing efforts to implement pharmacogenetics in clinical practice.
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Cites
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Cohen, J. C., Boerwinkle, E., Mosley, T. H., & Hobbs, H. H. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054013 · Cited by 3,181
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The support of human genetic evidence for approved drug indications
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Temporal Trends in Rates of Patient Harm Resulting from Medical Care
Landrigan, C. P., Parry, G. J., Bones, C. B., Hackbarth, A. D., Goldmann, D. A., & Sharek, P. J. (2010) · New England Journal of Medicine · doi:10.1056/nejmsa1004404 · Cited by 1,144
Loss-of-Function Mutations in APOC3, Triglycerides, and Coronary Disease
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A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease
Abul-Husn, N. S., Cheng, X., Li, A. H., Xin, Y., Schurmann, C., Stevis, P., Liu, Y., Kozlitina, J., Stender, S., Wood, G. C., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1712191 · Cited by 827
Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease
Dewey, F. E., Gusarova, V., O’Dushlaine, C., Gottesman, O., Trejos, J., Hunt, C., Van Hout, C. V., Habegger, L., Buckler, D., Lai, K.-M. V., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1510926 · Cited by 497
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease
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Loss-of-function mutations in SLC30A8 protect against type 2 diabetes
Go-T2D Consortium, Flannick, J., T2D-GENES Consortium, Thorleifsson, G., Beer, N. L., Jacobs, S. B. R., Grarup, N., Burtt, N. P., Mahajan, A., Fuchsberger, C., et al. (2014) · Nature Genetics · doi:10.1038/ng.2915 · Cited by 492
Cited by
Glucose-6-phosphate dehydrogenase deficiency
Luzzatto, L., Ally, M., & Notaro, R. (2020) · Blood · doi:10.1182/blood.2019000944 · Cited by 406
Longevity leap: mind the healthspan gap
Garmany, A., Yamada, S., & Terzic, A. (2021) · npj Regenerative Medicine · doi:10.1038/s41536-021-00169-5 · Cited by 252
Claudio‐Campos, K., Padrón, A., Jerkins, G., Nainaparampil, J., Nelson, R., Martin, A., Wiisanen, K., Smith, D. M., Strekalova, Y., Marsiske, M., et al. (2021) · Clinical and Translational Science · doi:10.1111/cts.12914 · Cited by 24
Pharmacogenetic/Pharmacogenomic Tests for Treatment Prediction in Depression
Islam, F., Gorbovskaya, I., & Müller, D. J. (2021) · Advances in Experimental Medicine and Biology · doi:10.1007/978-981-33-6044-0_13 · Cited by 6
Learning chemical sensitivity reveals mechanisms of cellular response
Connell, W., Garcia, K., Goodarzi, H., & Keiser, M. J. (2024) · Communications Biology · doi:10.1038/s42003-024-06865-4 · Cited by 4
Metadata
- Authors
- Roden, D. M., McLeod, H. L., Relling, M. V., Williams, M. S., Mensah, G. A., Peterson, J. F., & Van Driest, S. L.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2019-08
- Volume
- 394
- Issue
- 10197
- Pages
- 521-532
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W4210378359
- Cited by
- 427
- References
- 12
- FWCI
- 43.03
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Pharmacogenomics. https://app.cochat.ai/papers/10.1016/s0140-6736(19)31276-0
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- Roden, D. M., McLeod, H. L., Relling, M. V., Williams, M. S., Mensah, G. A., Peterson, J. F., & Van Driest, S. L. (2019). Pharmacogenomics. The Lancet. https://doi.org/10.1016/s0140-6736(19)31276-0
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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