Antibody response to first BNT162b2 dose in previously SARS-CoV-2-infected individuals
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In people with prior infection, a single vaccine dose triggers swift, strong recall of humoral immunity, and neutralizing activity usually surpasses that seen after two doses in infection-naive people.
“the vaccination of previously infected individuals drives a rapid and very potent recall of humoral immunity, even after a single vaccine dose70–72, with serological neutralizing activity generally exceeding levels seen after two vaccine doses in naive participants.”
From Prospects for durable immune control of SARS-CoV-2 and prevention of reinfection (2021) · cites this paper as [72]
Vaccines have increased immunogenicity in individuals with past infection and these people have higher antibody titres than those without previous infection.
“It has been shown that vaccines have increased immunogenicity in individuals with past infection and these people have higher antibody titres than those without previous infection.22, 23, 25”
From Vaccine side-effects and SARS-CoV-2 infection after vaccination in users of the COVID Symptom Study app in the UK: a prospective observational study (2021) · cites this paper as [25]
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References 4 · Cited by 369
Research works printed but not linked: 1
- [3]Walsh EE Frenck RW Falsey AR Safety and immunogenicity of two RNA-based COVID-19 vaccine candidates N Engl J Med 383 2020 2439 2450 33053279 PMC7583697
- Authors
- Manisty, C., Otter, A. D., Treibel, T. A., McKnight, Á., Altmann, D. M., Brooks, T., Noursadeghi, M., Boyton, R. J., Semper, A., & Moon, J. C.
- Affiliations
- St Bartholomew's Hospital (GB)
- Public Health England (GB)
- Queen Mary University of London (GB)
- Imperial College London (GB)
- University College London (GB)
- Royal Brompton & Harefield NHS Foundation Trust (GB)
- Corresponding author
- Boyton, Rosemary J
- ORCID
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2021-03
- Volume
- 397
- Issue
- 10279
- Pages
- 1057-1058
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- PMC
- PMC7972310
- OpenAlex
- W3135260899
- Cited by
- 369
- References
- 4
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 24 · 2023: 26 · 2022: 129 · 2021: 180
- FWCI
- 28.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Lancet (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Queen Mary Research Online (Queen Mary University of London) (submittedVersion)
- Spiral (Imperial College London) (submittedVersion, cc-by-nc-nd)
- Funders
- Barts Charity
- Wellcome Trust
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Social Sciences › Health › Vaccine Coverage and Hesitancy
- Keywords
- BNT162b2, COVID-19 vaccines, COVID-19 pandemic, prior infection, antibody response, spike protein, booster vaccination, immune priming, vaccine immunogenicity, nested case-control study, SARS-CoV-2 variants, Omicron BA.1, Omicron BA.2, Omicron BA.4/BA.5, alpha, beta, gamma
- MeSH terms
- Immunogenicity, Vaccine, COVID-19, SARS-CoV-2, COVID-19 Vaccines, BNT162 Vaccine, Antibodies, Viral, Humans, Immunization Schedule, Case-Control Studies, Asymptomatic Infections
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