Effect of previous SARS-CoV-2 infection on humoral and T-cell responses to single-dose BNT162b2 vaccine
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In people with prior infection, a single vaccine dose triggers swift, strong recall of humoral immunity, and neutralizing activity usually surpasses that seen after two doses in infection-naive people.
“the vaccination of previously infected individuals drives a rapid and very potent recall of humoral immunity, even after a single vaccine dose70–72, with serological neutralizing activity generally exceeding levels seen after two vaccine doses in naive participants.”
From Prospects for durable immune control of SARS-CoV-2 and prevention of reinfection (2021) · cites this paper as [71]
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References 16 · Cited by 271
Research works printed but not linked: 1
- [2]Walsh EE Frenck RW Jr Falsey AR Safety and immunogenicity of two RNA-based Covid-19 vaccine candidates New Eng J Med 383 2020 2439 2450 33053279 PMC7583697
- Authors
- Prendecki, M., Clarke, C., Brown, J., Cox, A., Gleeson, S., Guckian, M., Randell, P., Pria, A. D., Lightstone, L., Xu, X.-N., Barclay, W., McAdoo, S. P., Kelleher, P., & Willicombe, M.
- Affiliations
- Imperial College Healthcare NHS Trust (GB)
- Imperial College London (GB)
- North West London Pathology (GB)
- Chelsea and Westminster Hospital (GB)
- Corresponding author
- Prendecki, Maria
- ORCID
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2021-03
- Volume
- 397
- Issue
- 10280
- Pages
- 1178-1181
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- PMC
- PMC7993933
- OpenAlex
- W3133936567
- Cited by
- 271
- References
- 16
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 18 · 2023: 18 · 2022: 93 · 2021: 132
- FWCI
- 20.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Lancet (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Spiral (Imperial College London) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institute for Health Research
- Wellcome Trust
- Manchester Biomedical Research Centre
- Imperial College Healthcare NHS Trust
- Department for International Development, UK Government
- Imperial College London
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Social Sciences › Health › Vaccine Coverage and Hesitancy
- Keywords
- COVID-19 pandemic, prior infection, BNT162b2, mRNA vaccines, humoral immune response, T cell response, vaccine efficacy, healthcare workers, SARS-CoV-2 spike protein
- MeSH terms
- COVID-19, SARS-CoV-2, COVID-19 Vaccines, BNT162 Vaccine, Adult, Aged, Humans, Middle Aged, T-Lymphocytes, Immunity, Humoral, Enzyme-Linked Immunospot Assay, Spike Glycoprotein, Coronavirus
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