Rethinking chronic pain
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CP is often the result of abnormal neural signalling with biopsychosocial contributions.
“CP is a complex issue and is often the result of ab normal neural signalling with biopsychosocial contribu tions. 57”
From The Effectiveness of Interventions for Improving Chronic Pain Symptoms Among People With Mental Illness: A Systematic Review (2024) · cites this paper as [57]
There is over-reliance on medication prescribing among clinicians.
“and over-reliance on medication prescribing among clinicians, 57”
From The Effectiveness of Interventions for Improving Chronic Pain Symptoms Among People With Mental Illness: A Systematic Review (2024) · cites this paper as [57]
Cited by
Sorted by citations
Ho, E. K.-Y., Chen, L., Simic, M., Ashton-James, C. E., Comachio, J., Wang, D. X. M., Hayden, J. A., Ferreira, M. L., & Ferreira, P. H. (2022) · BMJ · doi:10.1136/bmj-2021-067718 · Cited by 220 · see citing works
Clinical Diagnosis and Treatment of Chronic Pain
Rahman, S., Kidwai, A., Rakhamimova, E., Elias, M., Caldwell, W., & Bergese, S. D. (2023) · Diagnostics · doi:10.3390/diagnostics13243689 · Cited by 38 · see citing works
“Policy makers and regulators need to be alerted to the economic and personal burden of this widely common disease to better diagnose and classify chronic pain conditions [83].”
BackgroundGroenveld, T. D., Smits, M., Knoop, J., Kallewaard, J. W., Staal, J. B., de Vries, M., & van Goor, H. (2023) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000001110 · Cited by 55 · see citing works
Zhu, K., Wang, L., Liao, T.-T., Li, W., Zhou, J., You, Y.-D., & Shi, J. (2023) · European journal of medicinal chemistry · doi:10.1016/j.ejmech.2023.115806 · Cited by 29 · see citing works
Scoping Review: The Role of Psychedelics in the Management of Chronic Pain
Robinson, C. L., Fonseca, A., Diejomaoh, E. M., D'Souza, R. S., Schatman, M. E., Orhurhu, V., & Emerick, T. D. (2024) · Journal of Pain Research · doi:10.2147/jpr.s439348 · Cited by 38 · see citing works
“25,27,29 34–36”
Are psychedelic medicines the reset for chronic pain? Preliminary findings and research needs
Zia, F. Z., Baumann, M. H., Belouin, S. J., Dworkin, R. H., Ghauri, M. H., Hendricks, P. S., Henningfield, J. E., Lanier, R. K., Ross, S., & Berger, A. M. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109528 · Cited by 31 · see citing works
Chronic struggle: an institutional ethnography chronic pain and marginalization.
Webster, F., Connoy, L., Sud, A., Rice, K., Katz, J., Pinto, A., Upshur, R., & Dale, C. M. (2022) · Journal of Pain · doi:10.1016/j.jpain.2022.10.004 · Cited by 26 · see citing works
Armstrong, M., Castellanos, J. P., & Christie, D. (2024) · Frontiers in Pain Research · doi:10.3389/fpain.2024.1346053 · Cited by 17 · see citing works
Ma, R., Romano, E., Ashworth, M., Smith, T. O., Vancampfort, D., Scott, W., Gaughran, F., Stewart, R., & Stubbs, B. (2024) · The Journal of Pain · doi:10.1016/j.jpain.2023.11.004 · Cited by 19 · see citing works
Liang, Y.-N., Luo, M., Xu, Q., Zhang, S., Niu, S.-Y., Li, X., Sun, W.-Z., Song, M.-X., Wang, L.-K., Xing, X.-X., et al. (2025) · British Journal of Anaesthesia · doi:10.1016/j.bja.2025.04.048 · Cited by 17 · see citing works
Herrero, P., Val, P., Lapuente‐Hernández, D., Cuenca‐Zaldívar, J. N., Calvo, S., & Gómez-Trullén, E. M. (2024) · Healthcare · doi:10.3390/healthcare12050505 · Cited by 19 · see citing works
Ng, W., Beales, D. J., Gucciardi, D. F., & Slater, H. (2023) · Frontiers in Pain Research · doi:10.3389/fpain.2023.1169178 · Cited by 18 · see citing works
Ram, A., Booth, J., Thom, J. M., Gibbs, M. T., & Jones, M. D. (2022) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000001086 · Cited by 16 · see citing works
Person-centered versus body-centered approaches in osteopathic care for chronic pain conditions
Álvarez, G., Zegarra-Parodi, R., & Esteves, J. (2021) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x211029417 · Cited by 14 · see citing works
Qiao, B., Song, X., Zhang, N., Xu, M., Zhuang, B., Guo, H., Wu, W., Yang, Z., Xie, X., Luan, Y., et al. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.01.004 · Cited by 15 · see citing works
Central sensitization in women with endometriosis: a cross-sectional study
Biasioli, A., Previtera, F., Mazzera, I., Degano, M., Zermano, S., Tius, V., Piacenti, I., Seracchioli, R., Raimondo, D., Martina, M. D., et al. (2026) · BMC Women s Health · doi:10.1186/s12905-026-04348-8 · Cited by 10 · see citing works
Wu, P., Chen, X.-X., Wang, S., Chen, X.-X., & Liu, J. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.119630 · Cited by 9 · see citing works
Song, X., Luan, M., Zhang, W., Zhang, R., Xue, L., & Luan, Y. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s367190 · Cited by 12 · see citing works
Mental pain as a global person-centered outcome measure
Cosci, F., Mansueto, G., Benemei, S., Chiarugi, A., Cesaris, F. D., & Sensky, T. (2021) · CNS Spectrums · doi:10.1017/s1092852921000699 · Cited by 7 · see citing works
“Second, our findings support the potentially wide benefit of interventions aimed to reduce mental pain, such as well-being therapy,(9) in addition to strategies which have been already widely encouraged in chronic pain patients, such as a strong therapeutic alliance and shared decision-making.(39)”
BackgroundGorgon, E. J. R., Maka, K., Kam, A. C., Nisbet, G., Sullivan, J., Regan, G., Pourkazemi, F., Lin, J., Mohamed, M., & Leaver, A. M. (2022) · Health Expectations · doi:10.1111/hex.13419 · Cited by 10 · see citing works
“The participants were reflective of the back pain cases referred to the hospital,(33,34) most of which were complex and chronic and often required long‐term solutions and multimodal management in the community.(70) There is a need to visualize the ideal hospital service and the changes that can be implemented realisti…”
BackgroundWang, Y., Zhou, W.-Y., Zhang, F.-Q., Wei, J., Wang, S., Min, K., Chen, Y.-L., Yang, H., & Lv, X. (2024) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13905 · Cited by 5
“3,4 Low back pain and headache have been recognized as the primary contributors to disability.”
Milkias, M., Mekonnen, S., Ahmed, S., Getachew, H., Adamu, Y., Mola, S., & Gugsa, T. (2023) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000001258 · Cited by 7 · see citing works
Hodgson, P., Hemmings, L., Stubbs, B., Vancampfort, D., & Byrd, E. (2025) · Healthcare · doi:10.3390/healthcare13030279 · Cited by 4 · see citing works
“Given the complex relationship between chronic pain and mental health, physiotherapists should be integrated into the diagnostic and management processes, reducing the reliance on medication and addressing chronic pain more holistically [42].”
Delivering equitable pain care: Lessons from the Scottish Service Model for Chronic Pain
Macgregor, C., Seenan, C., & Blane, D. (2023) · British Journal of Pain · doi:10.1177/20494637231180485 · Cited by 4 · see citing works
“The framework plans offer a practical and strategic approach similar to the ideas expressed in the Lancet’s recent ‘rethinking chronic pain’ editorial.(18) Importantly in Scotland, services are not subject to competitive tendering contracts, as they are in England, with the Scottish Government and health boards retain…”
MethodBack pain and musculoskeletal pain as public health problems: Rural communities await solution
Bang, A. A., Bhojraj, S. Y., & Bang, A. T. (2021) · Journal of Global Health · doi:10.7189/jogh-11-01007 · Cited by 3 · see citing works
Jin, D., Yang, H.-Y., Chen, Z., Hong, Y.-X., Ma, H., Xu, Z.-Z., Cao, B., Fei, F., Zhang, Y., Wu, W., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1396790 · Cited by 3 · see citing works
“In addition to the impact of injury or disease, there are physical perception, psychological and emotional changes, genetic factors, etc. Due to the complexity of pain, the results of the current treatment of chronic pain are unsatisfactory (The, 2021).”
BackgroundYin, L., Yin, M., Fan, Z., Shi, Y.-X., Shan, J., Wang, L., Chen, Y., Hao, C., Zhuang, T., Liu, T., et al. (2026) · Bioorganic chemistry (Print) · doi:10.1016/j.bioorg.2026.109785 · Cited by 2 · see citing works
Bohlen, L., Eggart, M., Müller-Oerlinghausen, B., Lorenz, J., Schleip, R., Liem, T., Cerritelli, F., Esteves, J. E., Mora, M. C. S., & Schmidt, T. (2025) · BMJ Open · doi:10.1136/bmjopen-2024-094747 · Cited by 4 · see citing works
“112 113 More specifically, the osteopath will choose freely which manual treatment and patient management approaches to apply for each subject.”
How Does Self-Declared Chronic Pain Compare to Other Definitions? A Prospective Multicenter Study
Daoust, R., Paquet, J., Perry, J. J., Yan, J. W., Williamson, D., Castonguay, V., Lavigne, G., Rouleau, D., Lessard, J., & Cournoyer, A. (2025) · Pain Research and Management · doi:10.1155/prm/5556400 · Cited by 2 · see citing works
“Self-declared chronic pain could be a simple alternative to complex operational defnitions; these patients could also be more receptive to chronic pain treatment approaches and diligent with the partnership associated with the quality of rehabilitation [27, 53, 54].”
Attending to the Moral Meaning of Pain.
Bernhofer, E. (2023) · Pain Management Nursing · doi:10.1016/j.pmn.2023.10.003 · Cited by 2
Pain Reprocessing Therapy – Schmerz neu denken
Kallweit, A., & Schubiner, H. H. (2025) · Der Schmerz · doi:10.1007/s00482-025-00889-3 · Cited by 1 · see citing works
Pacheco-Barrios, K., Simis, M., de Melo, P. S., Rebello-Sanchez, I., Vasquez-Avila, K., Barbosa, S., Gonzalez-Mego, P., Battistella, L., Imamura, M., & Fregni, F. (2025) · Brazilian Journal of Anesthesiology · doi:10.1016/j.bjane.2025.844639 · Cited by 1 · see citing works
dos Santos, B. C., Reis, A. K. G., Nucci, R. A. B., Campos, A. C. P., Martins, D. O., Daldegan‐Bueno, D., & Pagano, R. L. (2024) · Brain Behavior and Immunity Integrative · doi:10.1016/j.bbii.2024.100087 · Cited by 1 · see citing works
Austin, R. R., Alexander, S. L., Jantraporn, R., & Rajamani, S. (2024) · Pain Management Nursing · doi:10.1016/j.pmn.2024.09.004 · Cited by 1 · see citing works
Roberts, K. E., Baysari, M. T., Ho, E. K., Beckenkamp, P. R., Tian, Y., Jennings, M. D., Amorim, A. B., Maka, K., Morton, R. L., Ceprnja, D., et al. (2024) · BMC Health Services Research · doi:10.1186/s12913-024-11509-8 · Cited by 1 · see citing works
“A 2021 Lancet editorial on chronic pain called for chronic pain care to be ‘grounded in the community’ supported by well-trained, multidisciplinary healthcare workers [53].”
BackgroundAreunete, G. S., Gavazza, C. Z., de Oliveira, B. F. A., & Villela, N. R. (2024) · Pain Management Nursing · doi:10.1016/j.pmn.2024.07.008 · Cited by 2 · see citing works
The excitatory neurotransmitter glutamate and its receptors: the culprits behind neuropathic pain?
Qi, P.-F., Sun, Z.-R., & Yin, H.-N. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1951251
Li, Q.-L., Wang, J.-J., Zhang, M.-X., Sun, Q.-D., Xu, D.-S., Pi, F.-C., Peng, M., Feng, C., Zhu, Z.-H., Wang, Y., et al. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158692
He, Z., & Chen, X. (2026) · Frontiers in Public Health · doi:10.3389/fpubh.2026.1763838
“Chronic pain is a disease in itself, rather than just a symptom, and requires professional treatment (3, 4).”
Haug, S. H. K., & DeMarinis, V. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1546150
“This is due to the high rate of opioid prescriptions and the signi fi cant personal and social consequences of living with chronic pain (11).”
InfluentialLooking Past the Single Diagnosis: Resetting Our Perspective on Pain and Multimorbidity.
Boon, J. T. (2025) · Pain Management Nursing · doi:10.1016/j.pmn.2025.12.010
Eklund, K., Stålnacke, B., Enthoven, P., Zingmark, M., & Stenberg, G. (2025) · Scandinavian Journal of Pain · doi:10.1515/sjpain-2025-0024
“…pain, including direct costs such as medications and HCU and indirect costs such as productivity loss due to sickness absence and disability pension, have been estimated as 3 – 10% of the gross domestic production [1,18,19], excluding costs due to the reduced quality of life and informal care [20].”
Tratamiento del dolor persistente, evidencias
Dalmau-Roig, A., Castaño-Asins, J. R., & Morral, A. (2024) · Formacion Medica Continuada En Atencion Primaria · doi:10.1016/j.fmc.2024.05.003
Nurses’ Attitudes Toward Patients with Chronic Pain
Demir, O., & Selçuk, E. D. (2026) · European Archives of Medical Research · doi:10.14744/eamr.2025.75010
- Authors
- Lancet, T.
- Corresponding author
- The Lancet
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2021-05
- Volume
- 397
- Issue
- 10289
- Pages
- 2023
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W4206049742
- Cited by
- 61
- References
- 0
- Citations by year
- 2026: 10 · 2025: 10 · 2024: 16 · 2023: 14 · 2022: 7 · 2021: 4
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric Pain Management Techniques
- Keywords
- chronic pain, stigma, mental health, self-esteem, absenteeism, socioeconomic deprivation, low back pain, disability, health system costs, quality of life, informal care
- MeSH terms
- Analgesics, Humans, Chronic Pain, Pain Management
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