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Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial
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Citations
Cites
Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke
Hacke, W., Kaste, M., Bluhmki, E., Brozman, M., Dávalos, A., Guidetti, D., Larrue, V., Lees, K. R., Medeghri, Z., Machnig, T., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0804656 · Cited by 6,684
Emberson, J., Lees, K. R., Lyden, P., Blackwell, L., Albers, G., Bluhmki, E., Brott, T., Cohen, G., Davis, S., Donnan, G., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60584-5 · Cited by 2,737
Wahlgren, N., Ahmed, N., Dávalos, A., Ford, G. A., Grond, M., Hacke, W., Hennerici, M. G., Kaste, M., Kuelkens, S., Larrue, V., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60149-4 · Cited by 2,379
von Kummer, R., Broderick, J. P., Campbell, B. C. V., Demchuk, A., Goyal, M., Hill, M. D., Treurniet, K. M., Majoie, C. B. L. M., Marquering, H. A., Mazya, M. V., et al. (2015) · Stroke · doi:10.1161/strokeaha.115.010049 · Cited by 1,409
Self-citationEuropean Stroke Organisation (ESO) guidelines on intravenous thrombolysis for acute ischaemic stroke
Berge, E., Whiteley, W., Audebert, H., De Marchis, G., Fonseca, A. C., Padiglioni, C., Pérez de la Ossa, N., Strbian, D., Tsivgoulis, G., & Turc, G. (2021) · European Stroke Journal · doi:10.1177/2396987321989865 · Cited by 1,355
Do Clinicians Overestimate the Severity of Intracerebral Hemorrhage?
Tilling, E. J., El Tawil, S., & Muir, K. W. (2019) · Stroke · doi:10.1161/strokeaha.118.022606 · Cited by 1,120
Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke
Campbell, B. C. V., Mitchell, P. J., Churilov, L., Yassi, N., Kleinig, T. J., Dowling, R. J., Yan, B., Bush, S. J., Dewey, H. M., Thijs, V., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1716405 · Cited by 885
Saver, J. L., Fonarow, G. C., Smith, E. E., Reeves, M. J., Grau-Sepulveda, M. V., Pan, W., Olson, D. M., Hernandez, A. F., Peterson, E. D., & Schwamm, L. H. (2013) · JAMA · doi:10.1001/jama.2013.6959 · Cited by 870
A Randomized Trial of Tenecteplase versus Alteplase for Acute Ischemic Stroke
Parsons, M., Spratt, N., Bivard, A., Campbell, B., Chung, K., Miteff, F., O'Brien, B., Bladin, C., McElduff, P., Allen, C., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1109842 · Cited by 680
Logallo, N., Novotny, V., Assmus, J., Kvistad, C. E., Alteheld, L., Rønning, O. M., Thommessen, B., Amthor, K.-F., Ihle-Hansen, H., Kurz, M., et al. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30253-3 · Cited by 463
Research works printed but not linked: 6
- Huang, 2016, Tenecteplase versus alteplase in stroke thrombolysis: an individual patient data meta-analysis of randomized controlled trials, Int J Stroke, 11, 534, 10.1177/1747493016641112 · doi:10.1177/1747493016641112
- Campbell, 2020, Effect of intravenous tenecteplase dose on cerebral reperfusion before thrombectomy in patients with large vessel occlusion ischemic stroke: the EXTEND-IA TNK part 2 randomized clinical trial, JAMA, 323, 1257, 10.1001/jama.2020.1511 · doi:10.1001/jama.2020.1511
- Sajobi, 2022, Alteplase compared to tenecteplase in patients with acute ischemic stroke (AcT) trial: protocol for a pragmatic registry linked randomized clinical trial, Stroke Vasc Intervent Neurol, 0
- Faris, 2022, Ethical justification for deferral of consent in the AcT trial for acute ischemic stroke, Stroke, 10.1161/STROKEAHA.122.038760 · doi:10.1161/strokeaha.122.038760
- Singh, 2022, Understanding physician and patient preferences for thrombolysis in ischemic stroke eligible for endovascular thrombectomy, Stroke Vasc Intervent Neurol, 2
- Ahmed, 2016, The SITS-UTMOST: a registry-based prospective study in Europe investigating the impact of regulatory approval of intravenous Actilyse in the extended time window (3–4.5 h) in acute ischaemic stroke, Eur Stroke J, 1, 213, 10.1177/2396987316661890 · doi:10.1177/2396987316661890
Cited by
Kim, D. J., Singh, N., Catanese, L., Yu, A. Y. X., Demchuk, A. M., Lloret-Villas, M. I., Deschaintre, Y., Coutts, S. B., Khosravani, H., Appireddy, R., et al. (2024) · Stroke · doi:10.1161/strokeaha.123.045320 · Cited by 12
Self-citation
Metadata
- Authors
- Menon, B. K., Buck, B. H., Singh, N., Deschaintre, Y., Almekhlafi, M. A., Coutts, S. B., Thirunavukkarasu, S., Khosravani, H., Appireddy, R., Moreau, F., Gubitz, G., Tkach, A., Catanese, L., Dowlatshahi, D., Medvedev, G., Mandzia, J., Pikula, A., Shankar, J., Williams, H., Field, T. S., Manosalva, A., Siddiqui, M., Zafar, A., Imoukhuede, O., Hunter, G., Demchuk, A. M., Mishra, S., Gioia, L. C., Jalini, S., Cayer, C., Phillips, S., Elamin, E., Shoamanesh, A., Subramaniam, S., Kate, M., Jacquin, G., Camden, M.-C., Benali, F., Alhabli, I., Bala, F., Horn, M., Stotts, G., Hill, M. D., Gladstone, D. J., Poppe, A., Sehgal, A., Zhang, Q., Lethebe, B. C., Doram, C., Ademola, A., Shamy, M., Kenney, C., Sajobi, T. T., Swartz, R. H., Srivastava, A., Aljammaz, A. M., Akindotun, A. F., Jin, A. Y., Fraser, A., Khaw, A. V., Lemnaru, A., Southwell, A., Ramji, A., Alvarado-Bolaños, A., Mouminah, A., Lahlouh, A. B., Yu, A. Y., Alrohimi, A., Lavoie, A., Rogge, A., Micieli, A., Nguyen, A. L., Callaghan-Brown, A., Florendo-Cumbermack, A., Wadhwa, A., Beaudoin, A.-M., Cayley, A., Liddy, A. M., Trivedi, A., Katsanos, A. H., Shuaib, A., Butt, A. J., Bereznyakova, O., Beauchamp, B., Mahlitz, B., Graham, B. R., Dewar, B., Buck, B. H., Durafourt, B. A., Holtby, C., Jackson-Tarlton, C. S., Bockus, C., Stephenson, C., Galloway, C., Odier, C., Deacon, C., Zerna, C., Vekhande, C. C., Bocti, C., Stapf, C., Hawkes, C., Stables, C. A., Bogiatzi, C., Rodriguez, C., Candale-Radu, C., Murphy, C., Casserly, C. S., Fok, D., Boasquevisque, D. D. S., Wile, D., Volders, D., Sahlas, D. J., Shand, E., Cora, E. A., Battista, E. D., Stewart, E., Junk, E., Harrison, E. L., Frenette, E., Teleg, E., Abdellah, E., Ghrooda, E., Akthar, F., Evoy, F., Klein, G. M., Maclean, G., Jickling, G. C., Hawthorne, G., Boyd, G., Walker, G., Saposnik, G., Lau, H. L., Badr, H. E., Toma, H., Kalashyan, H., Marion-Moffet, H., Grant, I., Fatakdawala, I., Beaulieu-Boire, I., Williams, J., Brar, J., Rivest, J., Wang, J. Z., Dawe, J., Stang, J., Day, J., Miller, J., Gorman, J., Hopyan, J. J., Lee, J., Kromm, J., Foster, K., Ratnayake, K., Perera, K. S., Murray, K. V., Ryckborst, K., Lin, K., Sage, K., Sivakuma, K., MacDonald, K. A., Ng, K. K., Merchant, K., Khan, K., Ghavami, K., Johnston, K., Mai, L. M., White, L., Barratt, L., Longpre, L., Crellin, L., Peeling, L., Piquette, L., Lomax, L. B., Sadeghi, M., Kamra, M., Lavoie-April, M., Moores, M., Bullrich, M. B., McClelland, M., Salluzzi, M., Wilcox, M., Boulos, M. I., Marko, M., Boyko, M., Lantagne-Hurtubise, M., AlHamid, M. A., Shawawrah, M., Kelly, M. E., Thorne, M. W. D., Shamy, M., Bussiere, M., Dominc Tse, M. Y., Benguzzi, M., Sharma, M., Horton, M., Newcommon, N., Simon, N.-S., Parks, N. E., Sultan, N., Markovic, N., Daneault, N., Ishaque, N., Fairall, P., Kostyrko, P. B., Stys, P. K., Teal, P., Couillard, P., King-Azote, P., Collier, Q., Epp, R., Nair, R., Joundi, R. A., Jassal, R., Schneider, R., Hosseini, R., Bouchard, R., Whelan, R., Cooley, S. R., Sujanthan, S., Mansoor, S., Yip, Wasyliw, S., Taylor, S. W., Friedman, S., Mann, S., Maley, S. W., Chiasson, S., Hu, S. X., Althubait, S., Himed, S., Chen, S., Bal, S. S., Page, S. A., Beck, S. D., Woodroffe, S., Reiter, S. D., Gaal, S. V., Peters, S. R., Darvesh, S., Save, S., Alcock, S., Piercey, S., Adam, S., Gosselin, S., Fitzpatrick, T., Perron, T.-L., Stewart, T., Benstead, T. J., Naidoo, V., Wahab, W. A., Oczkowski, W., Kingston, W., Leduc, W., To, W. T. H., Yu, Y. J., Liu, Z. A., & Aljundi, Z. E.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2022-07
- Volume
- 400
- Issue
- 10347
- Pages
- 161-169
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W4283798291
- Cited by
- 474
- References
- 24
- FWCI
- 57.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
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- This page
- CoChat. (2026). Citation check: Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial. https://app.cochat.ai/papers/10.1016/s0140-6736(22)01054-6
- The paper
- Menon, B. K., Buck, B. H., Singh, N., Deschaintre, Y., Almekhlafi, M. A., Coutts, S. B., Thirunavukkarasu, S., Khosravani, H., Appireddy, R., Moreau, F., Gubitz, G., Tkach, A., Catanese, L., Dowlatshahi, D., Medvedev, G., Mandzia, J., Pikula, A., Shankar, J., Williams, H., . . . Aljundi, Z. E. (2022). Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial. The Lancet. https://doi.org/10.1016/s0140-6736(22)01054-6
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.