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Cited by 258Blood Pressure and Hypertension StudiesCardiovascular Health and Disease PreventionSodium Intake and Health

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients with high cardiovascular risk with and without diabetes or previous stroke: an open-label, blinded-outcome, randomised trial

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Honglei, Zhao, Huizhen, Zhao, Jindong, Zhao, Juan, Zhao, Liming, Zhao, Ling, Zhao, Lingshan, Zhao, Qingxia, Zhao, Qiuping, Zhao, Wanchen, Zhao, Wangxiu, Zhao, Weiyi, Zhao, Xiaodi, Zhao, Xiaojing, Zhao, Xiaoli, Zhao, Xiaoyan, Zhao, Xiling, Zhao, Yannan, Zhao, Yiyuan, Zheng, Shuzhen, Zheng, Xin, Zhi, Lixia, Zhong, Hui, Zhong, Qing, Zhong, Xin, Zhong, Yunzhi, Zhou, Jianfeng, Zhou, Jihu, Zhou, Ke, Zhou, Liangliang, Zhou, Ling, Zhou, Na, Zhou, Shengcheng, Zhou, Suyun, Zhou, Tao, Zhou, Wanren, Zhou, Weifeng, Zhou, Weijuan, Zhou, Xiaohong, Zhou, Yunke, Zhou, Yuquan, Zhou, Zhaohai, Zhou, Zhiming, Zhu, Bingpo, Zhu, Jifa, Zhu, Jing, Zhu, Mengnan, Zhu, Youcun, Zong, Dafei, Zuo, Hongbo, Zuo, Zhaokai·2024·The Lancet
DOI 10.1016/s0140-6736(24)01028-6
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Abstract

Background Uncertainty exists about whether lowering systolic blood pressure to less than 120 mm Hg is superior to that of less than 140 mm Hg, particularly in patients with diabetes and patients with previous stroke. Methods In this open-label, blinded-outcome, randomised controlled trial, participants with high cardiovascular risk were enrolled from 116 hospitals or communities in China. We used minimised randomisation to assign participants to intensive treatment targeting standard office systolic blood pressure of less than 120 mm Hg or standard treatment targeting less than 140 mm Hg. The primary outcome was a composite of myocardial infarction, revascularisation, hospitalisation for heart failure, stroke, or death from cardiovascular causes, assessed by the intention-to-treat principle. This trial was registered with ClinicalTrials.gov, NCT04030234. Findings Between Sept 17, 2019, and July 13, 2020, 11 255 participants (4359 with diabetes and 3022 with previous stroke) were assigned to intensive treatment (n=5624) or standard treatment (n=5631). Their mean age was 64·6 years (SD 7·1). The mean systolic blood pressure throughout the follow-up (except the first 3 months of titration) was 119·1 mm Hg (SD 11·1) in the intensive treatment group and 134·8 mm Hg (10·5) in the standard treatment group. During a median of 3·4 years of follow-up, the primary outcome event occurred in 547 (9·7%) participants in the intensive treatment group and 623 (11·1%) in the standard treatmen…

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  1. Whelton, 2018, Circulation, 138, e426

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Liu, J., Li, Y., Ge, J., Yan, X., Zhang, H., Zheng, X., Lu, J., Li, X., Gao, Y., Lei, L., Liu, J., Li, J., Ai, X., An, C., An, Y., Bai, S., Bai, X., Bi, J., Bin, X., Bu, M., Bu, P., Bu, W., Cai, L., Cai, N., Cai, S., Cai, T., Cai, W., Cao, B., Cao, B., Cao, H., Cao, L., Cao, X., Chai, H., Chai, Y., Chai, Z., Chang, C., Chang, J., Chang, S., Chang, Y., Chao, H., Che, H., Che, Q., Chen, D., Chen, D., Chen, F., Chen, G., Chen, H., Chen, H., Chen, H., Chen, H., Chen, J., Chen, J., Chen, J., Chen, J., Chen, J., Chen, J., Chen, J., Chen, L., Chen, L., Chen, L., Chen, Q., Chen, R., Chen, S., Chen, S., Chen, T., Chen, X., Chen, X., Chen, X., Chen, X., Chen, X., Chen, Y., Chen, Y., Chen, Y., Chen, Y., Chen, Y., Chen, Z., Chen, Z., Chen, Z., Cheng, C., Cheng, J., Cheng, X., Chu, J., Cui, R., Cui, X., Cui, X., Cui, Y., Cui, Z., Dai, W., Dai, X., Ding, C., Ding, H., Ding, Q., Ding, Y., Ding, Y., Dong, J., Dong, L., Dong, Q., Dong, Y., Du, B., Du, H., Du, J., Du, L., Du, M., Du, Q., Du, T., Du, X., 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Affiliations
Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Venue
The Lancet
Publisher
Elsevier BV
Published
2024-07
Volume
404
Issue
10449
Pages
245-255
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
DOI
10.1016/s0140-6736(24)01028-6
OpenAlex
W4400066882
Cited by
258
References
29
Citations by year
2026: 105 · 2025: 133 · 2024: 20
FWCI
77.61
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Servier
  • University of Oxford
  • National Key Research and Development Program of China (2018YFC1312400, 2018YFC1312401, 2018YFC1312404)
  • Tulane University
  • Capital Medical University
  • Ministry of Science and Technology of the People's Republic of China
  • Chinese Academy of Medical Sciences (NCRC2021001)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
Keywords
intensive blood pressure lowering, systolic blood pressure target, high cardiovascular risk, diabetes mellitus, stroke history, cardiovascular events, myocardial infarction, syncope, antihypertensive therapy, China, primary prevention of cardiovascular disease, secondary stroke prevention, revascularization, stroke recurrence, cardiovascular mortality
MeSH terms
Heart Disease Risk Factors, Aged, Antihypertensive Agents, Blood Pressure, Cardiovascular Diseases, China, Diabetes Mellitus, Female, Humans, Hypertension, Male, Middle Aged, Myocardial Infarction, Treatment Outcome, Stroke

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