ACUTE CHANGES IN THYROID FUNCTION IN PATIENTS TREATED WITH RADIOACTIVE IODINE
Abstract
Serum triiodothyronine (T3) and thyroxine (T4) were measured in thirteen unselected hyperthyroid patients before and at frequent intervals after iodine-131 treatment. There was an abrupt rise in T3 from a pretreatment mean of 250 ng/100 ml to a maximum of 365 ng/100 ml at 24 hours. Total T4 rose from a mean of 18.7 mug/100 ml to a maximum of 22.3 mug/100 ml at 24-48 hours. These findings may explain why an occasional patient develops acute thyroid crisis after radioiodine treatment.
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RAI can induce a short-term increase of thyroid hormone levels.
“However, RAI can induce a shortterm increase of thyroid hormone levels (74,75).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [74]
RAI treatment of Graves' disease can cause a transient exacerbation of hyperthyroidism.
“Because RAI treatment of GD can cause a transient exacerbation of hyperthyroidism, b-adrenergic blockade should be considered even in asymptomatic patients who are at increased risk for complications due to worsening of hyperthyroidism (i.e., elderly patients and patients with comorbidities).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [74]
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References 13 · Cited by 60
- Authors
- Shafer, R., & Nuttall, F.
- Affiliations
- University of Minnesota (US)
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1975-10
- Volume
- 306
- Issue
- 7936
- Pages
- 635-637
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2086559256
- Cited by
- 60
- References
- 13
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2016: 3 · 2015: 3 · 2014: 1
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- radioactive iodine, iodine-131, hyperthyroidism, thyroid function, triiodothyronine, thyroxine, thyroid storm, serum thyroid hormones
- MeSH terms
- Adult, Aged, Female, Humans, Hyperthyroidism, Iodine Radioisotopes, Male, Middle Aged, Radiotherapy Dosage, Thyroid Crisis, Thyroid Gland, Thyroxine, Triiodothyronine
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