RADIOTHERAPY AND HYPERBARIC OXYGEN IN HEAD AND NECK CANCER
Abstract
A controlled clinical trial is in progress to assess the value of hyperbaric oxygen and radiotherapy in the management of head and neck cancer. An established dose-fractionation schedule in hyperbaric oxygen is being compared with a widely used conventional schedule in air. Survival and local recurrence-free rates are significantly higher in the oxygen group, and the effects on normal tissue are similar in both groups. These findings suggest a genuine therapeutic advantage. There was a distinct improvement in the results of treating advanced laryngeal carcinoma, where there was a high survival rate, without resort to laryngectomy.
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Earlier clinical studies confirmed the importance of oxygen content in the biological effects of radiation therapy.
“Results from earlier clinical studies confirmed the importance of oxygen content in the biological effects of radiation therapy.”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [340]
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References 10 · Cited by 320
- Authors
- Henk, J. M., & Smith, C. W.
- Affiliations
- Velindre Cancer Centre (GB)
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1977-07
- Volume
- 310
- Issue
- 8029
- Pages
- 104-105
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2616852889
- Cited by
- 320
- References
- 10
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 5 · 2017: 3 · 2016: 2 · 2015: 9 · 2014: 7 · 2013: 4 · 2012: 6
- FWCI
- 29.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
- Keywords
- hyperbaric oxygen therapy, radiotherapy, head and neck cancer, laryngeal cancer, dose-fractionation schedules, local recurrence, survival, normal tissue toxicity, laryngectomy avoidance
- MeSH terms
- Clinical Trials as Topic, Evaluation Studies as Topic, Follow-Up Studies, Head and Neck Neoplasms, Humans, Hyperbaric Oxygenation, Laryngeal Neoplasms, Mouth Neoplasms, Neoplasm Recurrence, Local, Nose Neoplasms, Pharyngeal Neoplasms, Radiotherapy Dosage
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