The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
PREVENTION OF SPINAL OSTEOPOROSIS IN OOPHORECTOMISED WOMEN
Abstract
100 women who had taken part in a prospective controlled trial of oestrogen therapy for prevention of post-oophorectomy bone loss were reviewed after a median follow-up period of nine years. A significant reduction in height occurred among the placebo-treated group, but not in the group treated with mestranol (mean 23 x 3 micrograms/day). The placebo-treated group had a higher spine score, lower central vertebral height, and larger wedge-angle than the oestrogen group. Within each group none of these spinal morphometric changes correlated with changes in mineral content of metacarpal or radial bones as measured by photon absorptiometry or X-ray densitometry, although both peripheral and central measurements showed highly significant differences between groups. Oestrogen treatment, therefore, prevents against central, as well as peripheral, bone loss, and reduces the incidence of vertebral compression.
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In the citing paper
“Primary ovarian failure is associated with reduced BMD and increased risk of fractures (154-156), and estrogen replacement protects against fractures (154,157,158).”
From Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline (2016) · cites this paper as [158]
In the citing paper
“Nonetheless, the literature on primary ovarian failure supports the beneficial effects of estrogen on bone.”
From Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline (2016) · cites this paper as [158]
Citations
Cites
LONG-TERM PREVENTION OF POSTMENOPAUSAL OSTEOPOROSIS BY ŒSTROGEN
Lindsay, R., Aitken, J. M., Anderson, L., Hart, D., Macdonald, E., & Clarke, A. (1976) · The Lancet · doi:10.1016/s0140-6736(76)92217-0 · Cited by 875
Self-citationEffect of Estrogens and Calcium Carbonate on Bone Loss in Postmenopausal Women
Recker, R. R., Saville, P. D., & Heaney, R. P. (1977) · Annals of Internal Medicine · doi:10.7326/0003-4819-87-6-649 · Cited by 563
HUTCHINSON, T. (1979) · The Lancet · doi:10.1016/s0140-6736(79)90640-8 · Cited by 452
Prospective trial of oestrogen and calcium in postmenopausal women.
Horsman, A., Gallagher, J. C., Simpson, M., & Nordin, B. E. C. (1977) · BMJ · doi:10.1136/bmj.2.6090.789 · Cited by 374
BONE RESPONSE TO TERMINATION OF ŒSTROGEN TREATMENT
Lindsay, R., MacLean, A., Kraszewski, A., Hart, D. M., Clark, A. C., & Garwood, J. (1978) · The Lancet · doi:10.1016/s0140-6736(78)92402-9 · Cited by 324
Self-citationTreatment of spinal osteoporosis in postmenopausal women.
Nordin, B. E. C., Horsman, A., Crilly, R. G., Marshall, D. H., & Simpson, M. (1980) · BMJ · doi:10.1136/bmj.280.6212.451 · Cited by 198
Comparative Effects of Oestrogen and a Progestogen on Bone Loss in Postmenopausal Women
Lindsay, R., Hart, D. M., Purdie, D. W., Ferguson, M. M., Clark, A. S., & Kraszewski, A. (1978) · Clinical Science · doi:10.1042/cs0540193 · Cited by 185
Self-citationHealing trabecular microfractures in the bodies of lumbar vertebrae.
Vernon-Roberts, B., & Pirie, C. J. (1973) · Annals of the Rheumatic Diseases · doi:10.1136/ard.32.5.406 · Cited by 183
SKELETAL UPTAKE OF DIPHOSPHONATE
Fogelman, I., COHEN, H. N., Bessent, R. G., Hart, D. M., & Lindsay, R. S. (1980) · The Lancet · doi:10.1016/s0140-6736(80)92707-5 · Cited by 68
Self-citation5 Population Similarities in the Onset and Rate of Adult Endosteal Bone Loss
Garn, S. M., Rohmann, C. G., Wagner, B., Davila, G. H., & Ascoli, W. (1969) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-196907000-00006 · Cited by 66
Research works printed but not linked: 2
- Hutchinson, 1979, Postmenopausal oestrogens protect against fractures of hip and distal radius, Lancet, ii, 706
- Gordan, 1973, Antifracture efficacy of long-term oestrogens for osteoporosis, Trans Ass Am Physicians, 86, 326
Cited by
Sorted by citations
Neer, R. M., Arnaud, C. D., Zanchetta, J. R., Prince, R., Gaich, G. A., Reginster, J.-Y., Hodsman, A. B., Eriksen, E. F., Ish-Shalom, S., Genant, H. K., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105103441904 · Cited by 4,602
Hormone Therapy To Prevent Disease and Prolong Life in Postmenopausal Women
Grady, D., Rubin, S. M., Petitti, D. B., Fox, C. S., Black, D. M., Ettinger, B. B., Ernster, V. L., & Cummings, S. R. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-117-12-1016 · Cited by 2,329
Riggs, B. L., & Melton, L. J. (1986) · New England Journal of Medicine · doi:10.1056/nejm198606263142605 · Cited by 1,919
Sex Steroids and the Construction and Conservation of the Adult Skeleton
Riggs, B. L., Khosla, S., & Melton, L. J. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.3.0465 · Cited by 1,846
ESHRE Guideline: management of women with premature ovarian insufficiency
The ESHRE Guideline Group on POI, Webber, L. J., Davies, M. C., Anderson, R. A., Bartlett, J., Braat, D. D. M., Cartwright, B., Cífková, R., Keizer‐Schrama, S. D. M., Hogervorst, E., et al. (2016) · Human Reproduction · doi:10.1093/humrep/dew027 · Cited by 1,603
Metadata
- Authors
- Lindsay, R., Hart, D. M., Forrest, C., & Baird, C.
- Affiliations
- Helen Hayes Hospital (US)
- Western Infirmary (GB)
- ORCID
- Lindsay, R.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1980-11
- Volume
- 316
- Issue
- 8205
- Pages
- 1151-1154
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2004236425
- Cited by
- 706
- References
- 16
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 9 · 2022: 3 · 2021: 3 · 2020: 10 · 2019: 3 · 2018: 3 · 2017: 7 · 2016: 6 · 2015: 6 · 2014: 5 · 2013: 7 · 2012: 7
- FWCI
- 29.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- spinal osteoporosis, oophorectomy, estrogen therapy, bone loss prevention, vertebral compression, vertebral body height, wedge angle, bone mineral density, metacarpal bones, radial bone, postmenopausal women
- MeSH terms
- Body Height, Body Weight, Castration, Clinical Trials as Topic, Double-Blind Method, Female, Humans, Mestranol, Metacarpus, Osteoporosis, Radiography, Spinal Diseases, Spine
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