Difference in relapse rates of duodenal ulcer after healing with cimetidine or tripotassium dicitrato bismuthate
Abstract
In a double-blind randomised trial in 75 patients with duodenal ulceration diagnosed endoscopically, 38 patients were given tripotassium dicitrato bismuthate and 37 cimetidine. There was no significant difference in the healing rates between the two drugs after 1 and 2 months, although relief of symptoms was marginally quicker with cimetidine. During follow-up for at least a year, relapse was significantly more common in patients whose ulcers had healed during treatment with cimetidine than in those whose ulcers had healed during treatment with tripotassium dicitrato bismuthate. This difference appears to be related to the medication rather than to any other difference between the two groups of patients. These results suggest that drug treatment given for a short period in duodenal-ulcer disease influences the progress of the disease.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
30-40% of individuals treated successfully with bismuth salts had no recurrence of ulcer.
“However, 30–40% of those individuals treated successfully with bismuth salts had no recurrence of ulcer [11].”
From What would it take to prove that a chronic infection is a causal agent in Alzheimer’s disease? (2025) · cites this paper as [11]
No citation lists for this paper
No citation lists for this paper yet — checked again daily.
References 34 · Cited by 262
- Authors
- Martin, D., May, S., Tweedle, D. F., Hollanders, D., Ravenscroft, M., & Miller, J. P.
- Affiliations
- University of Manchester (GB)
- ORCID
- Miller, J.Paul
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1981-01
- Volume
- 317
- Issue
- 8210
- Pages
- 7-10
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2067990888
- Cited by
- 262
- References
- 34
- Citations by year
- 2025: 1 · 2023: 1 · 2019: 1 · 2017: 1 · 2015: 1
- FWCI
- 26.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal Bleeding Diagnosis and Treatment
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Keywords
- duodenal ulcer, ulcer healing, ulcer recurrence, cimetidine, tripotassium dicitrato bismuthate, Helicobacter pylori, H2 receptor antagonists, peptic ulcer treatment
- MeSH terms
- Adolescent, Adult, Aged, Bismuth, Cimetidine, Clinical Trials as Topic, Double-Blind Method, Duodenal Ulcer, Female, Guanidines, Humans, Male, Middle Aged, Organometallic Compounds, Random Allocation, Recurrence, Time Factors, Wound Healing
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
