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MEAN CELL VOLUME AND GAMMA-GLUTAMYL-TRANSPEPTIDASE AS MARKERS OF DRINKING IN WORKING MEN
Open accessAbstract
The usefulness of serum-gamma-glutamyl-transpeptidase (gamma-GT) and mean cell volume (MCV) as markers of alcohol consumption was assessed in men in employment (266 company directors and 222 manual workers in alcohol-production firms) and in 34 male alcoholic patients. The correlations of admitted consumption with gamma-GT were 0.307 (directors) and 0.418 (manual workers) and with MCV 0.439 (directors) and 0.360 (manual workers). A man with an MCV of over 98 fl and a gamma-GT level above 50 i.u./l had a 62% chance of admitting to drinking over 450 g alcohol per week. Although the probability of being a heavy drinker increases progressively with elevation in both these tests, as screening tests they lack power, though false positives may be explained in party by inaccurate self-reports by both survey subjects and patients. For clinical purposes, however, the tests have a use in supplementing self-report and in following problem drinkers in outpatient treatment.
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Cited by
SAUNDERS, J. B., AASLAND, O. G., BABOR, T. F., DE LA FUENTE, J. R., & GRANT, M. (1993) · Addiction · doi:10.1111/j.1360-0443.1993.tb02093.x · Cited by 13,597
Sobell, L. C., & Sobell, M. B. (1992) · Measuring Alcohol Consumption · doi:10.1007/978-1-4612-0357-5_3 · Cited by 4,110
Wallace, P., Cutler, S., & Haines, A. (1988) · BMJ · doi:10.1136/bmj.297.6649.663 · Cited by 648
Kristenson, H., Öhlin, H., Hultén‐Nosslin, M., Trell, E., & Hood, B. (1983) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.1983.tb05441.x · Cited by 382
Puddey, I. B., Beilin, L. J., Vandongen, R., Rouse, I. L., & Rogers, P. (1985) · Hypertension · doi:10.1161/01.hyp.7.5.707 · Cited by 293
Metadata
- Authors
- Chick, J., Kreitman, N., & Plant, M.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1981-06
- Volume
- 317
- Issue
- 8232
- Pages
- 1249-1251
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2148002823
- Cited by
- 229
- References
- 0
- FWCI
- 11.51
- Type
- journal article
- Language
- en
- Open access
- green
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- Chick, J., Kreitman, N., & Plant, M. (1981). MEAN CELL VOLUME AND GAMMA-GLUTAMYL-TRANSPEPTIDASE AS MARKERS OF DRINKING IN WORKING MEN. The Lancet. https://doi.org/10.1016/s0140-6736(81)92413-2
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