Cited by 468Nosocomial Infections in ICUPneumonia and Respiratory InfectionsAirway Management and Intubation Techniques

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ASPIRATION OF GASTRIC BACTERIA IN ANTACID-TREATED PATIENTS: A FREQUENT CAUSE OF POSTOPERATIVE COLONISATION OF THE AIRWAY

DUMOULIN, G·1982·The Lancet

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Abstract

The gastric and upper-airway flora of 60 consecutive patients treated with antacids or cimetidine in a respiratory/surgical intensive-therapy unit were studied. In 52 (87.0%) patients one or more organisms were cultured simultaneously from both upper airway and stomach. A sequence of transmission was clear in 17 of these patients. Pneumonia due to gram-negative bacilli developed in 31 patients; in most cases the causative organisms were of gastric origin. No pneumonia developed in the 8 patients whose gastric and upper-airway flora were different. The number of gram-negative bacilli in gastric aspirates correlated with the pH of the gastric aspirate. Treatment of seriously ill patients with antacids or cimetidine may encourage airway colonisation and predispose the patients to pneumonia caused by gram-negative bacilli.

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Authors: DUMOULIN, G.
Affiliations: Harvard University (US)
Corresponding author: DUMOULIN, G
Venue: The Lancet
Publisher: Elsevier BV
Published: 1982-01
Volume: 319
Issue: 8266
Pages: 242-245
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(82)90974-6
OpenAlex: W1480105763
Cited by: 468
References: 17
Citations by year: 2025: 3 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 8 · 2015: 4 · 2014: 1 · 2013: 8 · 2012: 7
FWCI: 15.81
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Airway Management and Intubation Techniques
Keywords: antacids, cimetidine, Gram-negative bacilli, aspiration pneumonia, critically ill patients, intensive care
MeSH terms: Antacids, Bacteria, Bacterial Infections, Gastroesophageal Reflux, Gram-Negative Aerobic Bacteria, Gram-Negative Anaerobic Bacteria, Humans, Intensive Care Units, Pneumonia, Pneumonia, Aspiration, Postoperative Complications, Respiratory Insufficiency, Stomach, Trachea

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ASPIRATION OF GASTRIC BACTERIA IN ANTACID-TREATED PATIENTS: A FREQUENT CAUSE OF POSTOPERATIVE COLONISATION OF THE AIRWAY

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