The DOI matches its Crossref record.
EFFECT OF ACUTE ALUMINIUM OVERLOAD ON CALCIUM AND PARATHYROID-HORMONE METABOLISM
Abstract
Accidental exposure of 25 patients on continuous ambulatory peritoneal dialysis to a high aluminium level in the dialysate for a month provided an opportunity to investigate the interrelation between the metabolism of parathyroid hormone (PTH), calcium, and aluminium. After exposure to the high-aluminium dialysate, the mean serum aluminium had risen from 1.85 to 7.11 mumol/l and serum calcium from 2.27 to 2.44 mmol/l, and serum PTH had fallen from 744 to 580 ng/l. After a further 2 months, during which time the dialysate was aluminium-free, the mean serum aluminium and calcium fell to previous levels. There were no changes in calcium or vitamin-D therapy which could have influenced these results. The rise in serum calcium and fall in PTH during a period of aluminium toxicity strongly support the hypothesis that aluminium suppresses PTH through an elevation of serum calcium.
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“bone pathology due to dysfunction of parathyroid gland (Cannata et al., 1983; Sherrard et al., 1985; Cournot-Witmer and Plachott, 1990; Díaz-Corte et al., 2001; Gonzelez-Suerez et al., 2005)”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Cannata et al., 1983
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Research works printed but not linked: 11
- Drüeke, 1980, Dialysis osteomalacia and aluminium intoxication, Nephron, 26, 207, 10.1159/000181985 · DOI
- Alfrey, 1980, Metabolism and toxicity of aluminium in renal failure, Am J Clin Nutr, 33, 1509, 10.1093/ajcn/33.7.1509 · DOI
- Cournot-Witmer, 1981, Aluminium localisation in bone from haemodialysed patients: relationship to matrix mineralisation, Kidney Int, 20, 375, 10.1038/ki.1981.149 · DOI
- Walker, 1982, Dialysate aluminium concentration and renal bone disease, Kidney Int, 21, 411, 10.1038/ki.1982.37 · DOI
- Mayor, 1980, Parathyroid hormone-mediated aluminium deposition and egress in the rat, Kidney Int, 17, 40, 10.1038/ki.1980.5 · DOI
- Cann, 1979, Aluminium uptake by the parathyroid glands, J Clin Endocr Metab, 49, 543, 10.1210/jcem-49-4-543 · DOI
- Cumming, 1982, Acute aluminium intoxication in patients on continuous ambulatory peritoneal dialysis, Lancet, i, 103, 10.1016/S0140-6736(82)90237-9 · DOI
- Boyce, 1982, Hypercalcaemic osteomalacia due to aluminium toxicity, Lancet, ii, 1009, 10.1016/S0140-6736(82)90049-6 · DOI
- Hodsman, 1982, Bone aluminium and histomorphometric features of renal osteodystrophy, J Clin Endocr Metab, 54, 539, 10.1210/jcem-54-3-539 · DOI
- Hodsman, 1981, Vitamin D-resistant osteomalacia in haemodialysis patients lacking secondary hyperparathyroidism, Ann Intern Med, 94, 629, 10.7326/0003-4819-94-5-629 · DOI
- Jb Cannata, Jd Briggs, Bjr Junor, G. Beastall, Gs Fell, Influence of aluminium on parathyroid hormone levels in haemodialysis patients, Proc Eur Dial Transplant Ass ((in press)).
Cited by
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Aluminium toxicosis: a review of toxic actions and effects
Igbokwe, I. O., Igwenagu, E., & Igbokwe, N. A. (2019) · Interdisciplinary Toxicology · doi:10.2478/intox-2019-0007 · Cited by 395
“, 2019), bone pathology due to dysfunction of parathyroid gland (Cannata et al., 1983; Sherrard et al., 1985; Cournot-Witmer and Plachott, 1990; Díaz-Corte et al., 2001; Gonzelez-Suerez et al., 2005), prediabetes and diabetes due to pancreatic islet damage (Wei et al.”
Background
Metadata
- Authors
- Cannata, J., Junor, B. R., Briggs, J. D., Fell, G., & Beastall, G.
- Affiliations
- Glasgow Royal Infirmary (GB)
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1983-03
- Volume
- 321
- Issue
- 8323
- Pages
- 501-503
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2045751162
- Cited by
- 72
- References
- 0
- Citations by year
- 2023: 1 · 2020: 1 · 2019: 1 · 2012: 2
- FWCI
- 8.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Keywords
- aluminum toxicity, aluminum overload, parathyroid hormone, calcium metabolism, serum calcium, serum aluminum, peritoneal dialysis, vitamin D supplementation, secondary hyperparathyroidism
- MeSH terms
- Accidents, Home, Aluminum, Bone and Bones, Calcium, Drug Contamination, Humans, Parathyroid Hormone, Peritoneal Dialysis, Continuous Ambulatory, Solutions, Tissue Distribution
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