HYPERINSULINISM IN ASPHYXIATED AND SMALL-FOR-DATES INFANTS WITH HYPOGLYCAEMIA
Abstract
Hypoglycaemia in birth-asphyxiated and small-for-dates infants is commonly attributed to glycogen depletion. However, 3 infants with asphyxia at birth and 3 small-for-dates infants had unequivocal hyperinsulinism. This suggests that hyperinsulinism may contribute to hypoglycaemia in small-for-dates and asphyxiated neonates.
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There is no assurance that the plasma lactate level will be sufficiently elevated to compensate for low glucose in high-risk neonates.
“Of concern, as noted previously,3 plasma ketone levels are suppressed during hypoglycemia in high-risk neonates, making them particularly vulnerable to hypoglycemia-induced brain damage, and there is no assurance the plasma lactate level will be sufficiently elevated to compensate for low glucose.27,28,30,39”
From Recommendations from the Pediatric Endocrine Society for evaluation and management of persistent hypoglycemia in neonates, infants, and children (2015) · cites this paper as [27]
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References 15 · Cited by 141
- Authors
- Collins, J. E., & Leonard, J. V.
- Affiliations
- Great Ormond Street Hospital (GB)
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1984-08
- Volume
- 324
- Issue
- 8398
- Pages
- 311-313
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2000377702
- Cited by
- 141
- References
- 15
- Citations by year
- 2025: 1 · 2024: 9 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 9 · 2016: 6 · 2015: 8 · 2014: 4 · 2013: 8 · 2012: 6
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal Health and Biochemistry
- Keywords
- neonatal hypoglycemia, hyperinsulinism, neonatal asphyxia, small for gestational age, glycogen depletion
- MeSH terms
- Asphyxia Neonatorum, Humans, Hyperinsulinism, Hypoglycemia, Infant, Newborn, Infant, Small for Gestational Age, Male
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