FREQUENCY OF TRUE ADVERSE REACTIONS TO MEASLES-MUMPS-RUBELLA VACCINE
Abstract
The vast majority of adverse reactions following immunisation of children with live measles-mumps-rubella (MMR) vaccine were shown in a double-blind, placebo-controlled, cross-over study in 581 twin pairs to be only temporally but not causally related to the vaccination. The true frequency of side-effects caused by MMR vaccine, estimated from the discordance rates of individual signs and symptoms between MMR vaccinees and their placebo-injected twins, was between 0.5 and 4.0%. Moreover, respiratory symptoms, nausea, and vomiting were observed more frequently in the placebo-injected group than in the MMR vaccinated group.
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Out of the five RCTs and one CCT assessing short-term side effects, only two studies (Lerman 1981; Peltola 1986) had adequate concealment.
“Out of the five RCTs and one CCT assessing short-term side effects, only two studies (Lerman 1981; Peltola 1986) had adequate concealment.”
From Vaccines for measles, mumps and rubella in children (2012) · cites this paper as Peltola 1986
In Peltola 1986, a trial in twins reported a possible protective effect of MMR vaccine with lower incidence of respiratory symptoms, nausea and vomiting, and no difference in other unintended side effects compared with placebo, except irritability.
“One trial (Peltola 1986) carried out in twins, reported a possible protective effect of the MMR vaccine with a lower incidence of respiratory symptoms, nausea and vomiting, and no difference in the incidence of other unintended side effects compared with placebo, with the exception of irritability.”
From Vaccines for measles, mumps and rubella in children (2012) · cites this paper as Peltola 1986
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References 18 · Cited by 212
- Authors
- Peltola, H., & Heinonen, O.
- Affiliations
- University of Helsinki (FI)
- ORCID
- Peltola, Heikki
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1986-04
- Volume
- 327
- Issue
- 8487
- Pages
- 939-942
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W1981159087
- Cited by
- 212
- References
- 18
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 6 · 2021: 6 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 7 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 9 · 2012: 4
- FWCI
- 6.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Social Sciences › Health › Vaccine Coverage and Hesitancy
- Keywords
- MMR vaccine, vaccine adverse events, live attenuated vaccine, vaccine safety, twin discordance, respiratory symptoms, nausea and vomiting, children
- MeSH terms
- Child, Child, Preschool, Clinical Trials as Topic, Double-Blind Method, Female, Fever, Humans, Infant, Male, Measles Vaccine, Mumps Vaccine, Surveys and Questionnaires, Rubella Vaccine, Time Factors, Twins, Vaccination
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