Use of recombinant granulocyte-macrophage colony stimulating factor in the Brazil radiation accident
Abstract
8 patients with bone marrow failure after a caesium-137 radiation accident were treated with recombinant human granulocyte-macrophage colony stimulating factor (rHuGM-CSF). The 7 who were evaluable had prompt increases in granulocytes and bone marrow cellularity. 2 patients died of radiation toxicity and haemorrhage and 2 of bacterial sepsis acquired before the start of rHuGM-CSF treatment. 4 patients survive, including 2 who were treated early and never became infected. This therapeutic approach to radiation-induced granulocytopenia may therefore be useful after radiation and nuclear accidents.
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Sargramostim is officially documented to have first been used under a compassionate use exemption to treat patients with radiation-induced myelosuppression following a radiological accident with a cesium source in Goiânia, Brazil in 1987.
“Sargramostim (Leukine®, Partner Therapeutics, Boston, MA) is officially documented to have first been used under a compassionate use exemption to treat patients with radiation-induced myelosuppression following a radiological accident with a cesium source in Goiânia, Brazil in 1987 (Butturini et al., 1988).”
From Medical countermeasures for the hematopoietic-subsyndrome of acute radiation syndrome in space (2022) · cites this paper as Butturini et al., 1988
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References 26 · Cited by 113
- Authors
- Butturini, A., Gale, R., Lopes, D., Cunha, C., Ho, W., Sanpai, J., De Souza, P., Cordiero, J., Neto, C., De Souza, C., Tabak, D., Burla, A., & The Navy Hospital Radiation Team
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1988-08
- Volume
- 332
- Issue
- 8609
- Pages
- 471-475
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2107579477
- Cited by
- 113
- References
- 26
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 3
- FWCI
- 16.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Blood disorders and treatments
- Keywords
- recombinant human granulocyte-macrophage colony-stimulating factor, bone marrow failure, nuclear accidents, hemorrhage, bacterial sepsis, granulocyte recovery, bone marrow cellularity
- MeSH terms
- Accidents, Acute Disease, Adolescent, Adult, Agranulocytosis, Brazil, Cesium Radioisotopes, Child, Colony-Stimulating Factors, Drug Evaluation, Environmental Exposure, Equipment Contamination, Female, Food Contamination, Radioactive, Growth Substances, Humans, Male, Middle Aged, Radiation Dosage, Radiation Injuries, Radioactive Waste, Recombinant Proteins, Time Factors, Granulocyte-Macrophage Colony-Stimulating Factor
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