The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
ANTI-RETROVIRAL EFFECTS OF INTERFERON-α IN AIDS-ASSOCIATED KAPOSI'S SARCOMA
Open accessAbstract
21 patients with AIDS and Kaposi's sarcoma were enrolled in an open therapeutic trial to determine the in vivo anti-retroviral activity of recombinant interferon-alpha (IFN-alpha). 8 (38%) showed a complete or partial anti-tumour response. The mean pretreatment CD4 count for the responders was 399 cells/microliter vs 154 cells/microliter for the non-responders. All 5 of the patients with more than 400 CD4 cells/microliter pretreatment showed a significant reduction in tumour, whereas none of the 7 patients with under 150 CD4 cells/microliter had any response. 5 of the 6 complete or partial responders with greater than 50 pg/ml of human immunodeficiency virus (HIV) p24 before IFN therapy showed a 75% or greater reduction by 12 weeks of therapy, with 3 patients having persistently negative HIV cultures. The anti-viral effects were also most pronounced in the patients with the highest CD4 counts. These data demonstrate the potential benefits, both anti-tumour and anti-retroviral, of treatment with IFN-alpha in the early stages of HIV infection and Kaposi's sarcoma.
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Citations
Cites
The Efficacy of Azidothymidine (AZT) in the Treatment of Patients with AIDS and AIDS-Related Complex
Fischl, M. A., Richman, D. D., Grieco, M. H., Gottlieb, M. S., Volberding, P. A., Laskin, O. L., Leedom, J. M., Groopman, J. E., Mildvan, D., Schooley, R. T., et al. (1987) · New England Journal of Medicine · doi:10.1056/nejm198707233170401 · Cited by 2,995
Cited by
Kovacs, J. A., Baseler, M., Dewar, R. J., Vogel, S., Davey, R. T., Falloon, J., Polis, M. A., Walker, R. E., Stevens, R., Salzman, N. P., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503023320904 · Cited by 425
Self-citationCirculating interferon-α levels and hypertriglyceridemia in the acquired immunodeficiency syndrome.
Grunfeld, C., Kotler, D. P., Shigenaga, J. K., Doerrler, W., Tierney, A., Wang, J., Pierson, R. N., & Feingold, K. R. (1991) · The American Journal of Medicine · doi:10.1016/0002-9343(91)90536-7 · Cited by 286
Metadata
- Authors
- Clifford Lane, H., Feinberg, J., Davey, V., Deyton, L., Baseler, M., Manischewitz, J., Masur, H., Kovacs, J., Herpin, B., Walker, R., Metcalf, J., Salzman, N., Quinnan, G., & Fauci, A.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1988-11
- Volume
- 332
- Issue
- 8622
- Pages
- 1218-1222
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2077468566
- Cited by
- 261
- References
- 1
- FWCI
- 13.00
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: ANTI-RETROVIRAL EFFECTS OF INTERFERON-α IN AIDS-ASSOCIATED KAPOSI'S SARCOMA. https://app.cochat.ai/papers/10.1016/s0140-6736(88)90811-2
- The paper
- Clifford Lane, H., Feinberg, J., Davey, V., Deyton, L., Baseler, M., Manischewitz, J., Masur, H., Kovacs, J., Herpin, B., Walker, R., Metcalf, J., Salzman, N., Quinnan, G., & Fauci, A. (1988). ANTI-RETROVIRAL EFFECTS OF INTERFERON-α IN AIDS-ASSOCIATED KAPOSI'S SARCOMA. The Lancet. https://doi.org/10.1016/s0140-6736(88)90811-2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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