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RANDOMISED TRIAL OF FISH OIL FOR PREVENTION OF RESTENOSIS AFTER CORONARY ANGIOPLASTY
Open accessAbstract
To examine the potential role of fish oil supplementation in the prevention of restenosis after coronary angioplasty (PTCA), a randomised double-blind trial was conducted in 204 patients. The treatment group received 6 g/day of n-3 fatty acids, beginning 5.4 (SD 3.2) days before PTCA, and continuing for 6 months; the control group received olive oil placebo. Compliance was assessed by pill count and plasma levels of eicosapentaenoic acid (EPA). Restenosis was identified by symptoms and exercise testing and confirmed by angiography. PTCA was successful in 186 patients (93%). The incidence of angiographic restenosis was 34% in the fish oil group and 23% in the control group (relative risk 1.7, 95% CI 0.9-3.4). The lack of benefit of fish oil was not influenced by length of pretreatment, compliance with study medication, or the concentrations of plasma EPA achieved.
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Citations
Cited by
Omega-3 Fatty Acids and Cardiovascular Disease
Mozaffarian, D., & Wu, J. H. Y. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.06.063 · Cited by 1,771
Patient Adherence and Medical Treatment Outcomes: A Meta-Analysis
Robin DiMatteo, M., Giordani, P. J., Lepper, H. S., & Croghan, T. W. (2002) · Medical Care · doi:10.1097/00005650-200209000-00009 · Cited by 1,490
Wang, C., Harris, W. S., Chung, M., Lichtenstein, A. H., Balk, E. M., Kupelnick, B., Jordan, H. S., & Lau, J. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.1.5 · Cited by 980
Bucher, H. C., Hengstler, P., Schindler, C., & Meier, G. (2002) · The American Journal of Medicine · doi:10.1016/s0002-9343(01)01114-7 · Cited by 823
Percutaneous Transluminal Coronary Angioplasty
Landau, C., Lange, R. A., & Hillis, L. D. (1994) · New England Journal of Medicine · doi:10.1056/nejm199404073301407 · Cited by 445
Metadata
- Authors
- Reis, G., Sipperly, M., Mccabe, C., Sacks, F., Boucher, T., Silverman, D., Baim, D., Grossman, W., & Pasternak, R.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1989-07
- Volume
- 334
- Issue
- 8656
- Pages
- 177-181
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2078563992
- Cited by
- 218
- References
- 0
- FWCI
- 32.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: RANDOMISED TRIAL OF FISH OIL FOR PREVENTION OF RESTENOSIS AFTER CORONARY ANGIOPLASTY. https://app.cochat.ai/papers/10.1016/s0140-6736(89)90370-x
- The paper
- Reis, G., Sipperly, M., Mccabe, C., Sacks, F., Boucher, T., Silverman, D., Baim, D., Grossman, W., & Pasternak, R. (1989). RANDOMISED TRIAL OF FISH OIL FOR PREVENTION OF RESTENOSIS AFTER CORONARY ANGIOPLASTY. The Lancet. https://doi.org/10.1016/s0140-6736(89)90370-x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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