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Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial
Abstract
Background Risk factors for nosocomial pneumonia, such as gastro-oesophageal reflux and subsequent aspiration, can be reduced by semirecumbent body position in intensive-care patients. The objective of this study was to assess whether the incidence of nosocomial pneumonia can also be reduced by this measure.Methods This trial was stopped after the planned interim analysis. 86 intubated and mechanically ventilated patients of one medical and one respiratory intensive-care unit at a tertiary-care university hospital were randomly assigned to semirecumbent (n=39) or supine (n=47) body position. The frequency of clinically suspected and microbiologically confirmed nosocomial pneumonia (clinical plus quantitative bacteriological criteria) was assessed in both groups. Body position was analysed together with known risk factors for nosocomial pneumonia.Findings The frequency of clinically suspected nosocomial pneumonia was lower in the semirecumbent group than in the supine group (three of 39 [8%] vs 16 of 47 [34%]; 95% CI for difference 10.0-42.0, p=0.003). This was also true for microbiologically confirmed pneumonia (semirecumbent 2/39 [5%] vs supine 11/47 [23%]; 4.2-31.8, p=0.018). Supine body position (odds ratio 6.8 [1.7-26.7], p=0.006) and enteral nutrition (5.7 [1.5-22.8], p=0.013) were independent risk factors for nosocomial pneumonia and the frequency was highest for patients receiving enteral nutrition in the supine body position (14/28, 50%). Mechanical ventilation for 7 days or more (10.9 [3.0-40.4], p=0.001) and a Glasgow coma scale score of less than 9 were additional risk factors.Interpretation The semirecumbent body position reduces frequency and risk of nosocomial pneumonia, especially in patients who receive enteral nutrition. The risk of nosocomial pneumonia is increased by long-duration mechanical ventilation and decreased consciousness.
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“Raising of the head of the patient’s bed decreases immigration to the lungs of gastric microbiota compared with supine positioning,149 but this practice also compromises microbial elimination from the lungs”
From The microbiome and critical illness (2016) · cites this paper as [149]
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Bonten, M. J. M. (2014) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.14017 · Cited by 4
Les « dix commandements » de la nutrition entérale en réanimation
Raynard, B., & Sellami-Deletang, N. (2010) · Réanimation · doi:10.1016/j.reaurg.2010.04.003 · Cited by 4
Fitch, Z. W., Duquaine, D. C., Ohkuma, R., Schneider, E. B., & Whitman, G. J. R. (2014) · American Journal of Medical Quality · doi:10.1177/1062860614556743 · Cited by 4
“The relationship between HOB angle compliance and decreased rates of VAP has been established by prior studies.(1-4) It was not an aim of this study to do so again, in particular because the infrequent occurrence of VAP in the study unit would have prevented any meaningful comparisons over this short time period.”
Drehen und Wenden - „Was ist eigentlich möglich?”
Rothaug, O., Sabel, K., & Kaltwasser, A. (2008) · intensiv · doi:10.1055/s-2007-963799 · Cited by 4
Crane, B. A., Wininger, M., & Kunsman, M. (2015) · Advances in Skin & Wound Care · doi:10.1097/01.asw.0000471877.19459.85 · Cited by 4
“This population is a longterm, very ill cohort, for example, those on ventilator support (for whom risk is high for VAP) or with minimal self-care abilities (for whom there is high risk of aspiration), such that a moderate HOB elevation of 30 to 45 degrees would be indicated.(56,57) Moreover, this population typically…”
BackgroundCan We Achieve Zero Hospital-Acquired Pneumonia?
Alves, J., Peña-López, Y., Rojas, J. N., Campins, M., & Rello, J. (2018) · Current treatment options in infectious diseases/Current treatment options in infectious disease · doi:10.1007/s40506-018-0164-x · Cited by 4
Yaghoobi, M. H., Karami, P., Khaledi, A., Rafie, E., Sabahi, M., Habibipour, B., Bashar, F. R., & Sedighi, I. (2019) · Journal of Advances in Medical and Biomedical Research · doi:10.30699/jambs.27.123.1 · Cited by 4
“There are some common causes of concerns in HAI groups of pediatrics and neonates (8).”
BackgroundEndotracheal Tube and Respiratory Care
Mort, T. C., Keck, J. P., & Meisterling, L. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-2764-7.00047-6 · Cited by 4
Care Bundle for Ventilator-Associated Pneumonia in a Medical Intensive Care Unit in Northern Taiwan
Zeng, W.-P., Su, H., Chen, C.-W., Cheng, S., Chang, L., Tzeng, W., & Tzeng, B. (2015) · Journal of Medical Sciences · doi:10.4103/1011-4564.156013 · Cited by 4
Yogun Bakimla Hizli Kucaklasma (Fast Hugs)
Şenoğlu, N., Köse, I., Zincircioğlu, Ç., & Erbay, R. H. (2014) · Türk yoğun bakım derneği dergisi/Türk yoğun bakım dergisi · doi:10.4274/tybdd.69885 · Cited by 4
“Mekanik ventilasyon uygulanan hastalarda başın 30-45 derece yükseltilmesinin gastroösefagial reflü ve nazokomiyal pnömoni insidansını azalttığı bulunmuştur (30,31).”
Asadullah, ., I., & Sri Ardila, N. (2017) · Saintika Medika · doi:10.22219/sm.v11i1.4197 · Cited by 4
Martí-Hereu, L., & Marañón, A. A. (2017) · Enfermería Intensiva (English ed ) · doi:10.1016/j.enfie.2017.02.003 · Cited by 4
Sepsis Management in Resource-Limited Settings
Arslantaş, M. K., & Özdemir, H. (2019) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000004536 · Cited by 4
Lheureux, O., & Preiser, J. (2019) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000626 · Cited by 4
“The relationship between enteral nutrition and, aspiration and ventilator-associated pneumonia (VAP) has been investigated during the last decades.”
ResultInfluential
Metadata
- Authors
- Drakulovic, M. B., Torres, A., Bauer, T. T., Nicolas, J. M., Nogué, S., & Ferrer, M.
- Affiliations
- Hospital Clínic de Barcelona (ES)
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1999-11
- Volume
- 354
- Issue
- 9193
- Pages
- 1851-1858
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2143385226
- Cited by
- 1,243
- References
- 37
- Citations by year
- 2026: 15 · 2025: 13 · 2024: 19 · 2023: 19 · 2022: 22 · 2021: 20 · 2020: 19 · 2019: 20 · 2018: 25 · 2017: 44 · 2016: 40 · 2015: 50 · 2014: 60 · 2013: 58 · 2012: 61
- FWCI
- 31.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Keywords
- nosocomial pneumonia, semi-recumbent position, mechanical ventilation, intensive care unit patients, enteral nutrition, risk factors, mechanical ventilation duration, Glasgow Coma Scale
- MeSH terms
- Aged, Analysis of Variance, Cross Infection, Enteral Nutrition, Female, Humans, Intensive Care Units, Male, Middle Aged, Pneumonia, Aspiration, Posture, Respiration, Artificial, Risk Factors, Spain, Time Factors, Incidence, Logistic Models, Odds Ratio, Supine Position, Hospital Mortality
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