A review of photocrosslinked polyanhydrides:
Abstract
Many orthopaedic injuries could benefit from a high-strength and degradable material with good tissue compatibility. In addition, there is a great clinical need for materials which are easily contoured or placed into complex-shaped defects by a surgeon. We have rationally designed a new class of photocrosslinkable polyanhydride monomers which in situ form high-strength and surface eroding networks of complex geometries. This paper highlights the advantages of these materials for orthopaedic applications and the technique of photopolymerization for reacting these monomers under physiological conditions. The rationale for the material design, photopolymerization kinetics, degradation behavior, and histology in subcutaneous tissue and a model bone defect are presented.
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Polyanhydride (I) is used to deliver carmustine, an anticancer drug, to sites in the brain where a tumor has been removed.
“Polyanhydride (I) is used to deliver carmustine, an anticancer drug, to sites in the brain where a tumor has been removed.”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Burkoth and Anseth, 2000
Photo cross-linkable polyanhydrides have been developed for use in orthopaedic applications, particularly focusing on achieving high mechanical strength.
“Photo cross-linkable polyanhydrides have also been developed for use in orthopaedic applications, particularly focusing on achieving high mechanical strength.”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Burkoth and Anseth, 2000
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References 26 · Cited by 191
- Authors
- Burkoth, A. K., & Anseth, K. S.
- Affiliations
- University of Colorado Boulder (US)
- Corresponding author
- Anseth, Kristi S.
- ORCID
- Anseth, Kristi S.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2000-12
- Volume
- 21
- Issue
- 23
- Pages
- 2395-2404
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W197010566
- Cited by
- 191
- References
- 26
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 8 · 2019: 4 · 2018: 6 · 2017: 6 · 2016: 4 · 2015: 8 · 2014: 5 · 2013: 9 · 2012: 12
- FWCI
- 5.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Association of University Women
- Colorado State University
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR44375)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Chemistry › Organic Chemistry › Photopolymerization techniques and applications
- Keywords
- photopolymerization, orthopedic implants, degradable polymers, surface erosion, photopolymerization kinetics, biodegradation, histocompatibility, bone defects
- MeSH terms
- Anhydrides, Animals, Biocompatible Materials, Biodegradation, Environmental, Kinetics, Male, Photochemistry, Rats, Sprague-Dawley, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Rats
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