The DOI matches its Crossref record; 124 of the 124 references it cites were found in a registry or an index.
Calcium dynamics and endoplasmic reticular function in the regulation of protein synthesis: implications for cell growth and adaptability
Abstract
The endoplasmic reticulum (ER) possesses the structural and functional features expected of an organelle that supports the integration and coordination of major cellular processes. Ca(2+) sequestered within the ER sustains lumenal protein processing while providing a reservoir of the cation to support stimulus-response coupling in the cytosol. Release of ER Ca(2+) sufficient to impair protein processing promotes ER stress and signals the "unfolded protein response" (UPR). The association of the UPR with an acute suppression of mRNA translational initiation and a longer term up-regulation of ER chaperones and partial translational recovery is discussed. Regulatory sites in mRNA translation and the mechanisms responsible for the early and later phases of the UPR are reviewed. The regulatory significance of GRP78/BiP, a multifunctional, broad-specificity ER chaperone, in the coordination of ER protein processing with mRNA translation during acute and chronic ER stress is addressed. The relationship of ER stress to protein misfolding in the cytoplasm is examined. Translational alterations in embryonic cardiomyocytes during treatments with various Ca(2+)-mobilizing, growth-promoting stimuli are described. The importance of ER Ca(2+) stores, ER chaperones, and cytosolic-free Ca(2+) in translational control and growth promotion by these stimuli is assessed. Some perspectives are provided regarding Ca(2+) as an integrating factor in the generation or diversion of metabolic energy. Circumstances impacting upon cellular adaptability during exposure to growth stimuli or during stressful conditions that require rapid adjustments in ATP for continued viability are considered.
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“ER stress can be detrimental to fungal cells if ER function is not restored because in addition to its crucial role in the posttranslational processing of proteins, the ER is also a key player in Ca 2ϩ signaling (32).”
From Cch1 Restores Intracellular Ca2+ in Fungal Cells during Endoplasmic Reticulum Stress (2010) · cites this paper as [32]
In the citing paper
“It is known that in eukaryotes the ER constitutes a finite reservoir of Ca 2ϩ primarily mobilized for signaling that must be replenished to sustain the duration of signaling and ultimately restore Ca 2ϩ homeostasis in the ER and the cytosol (1-3, 32).”
From Cch1 Restores Intracellular Ca2+ in Fungal Cells during Endoplasmic Reticulum Stress (2010) · cites this paper as [32]
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Metadata
- Authors
- Brostrom, M. A., & Brostrom, C. O.
- Corresponding author
- Brostrom, Margaret A
- Venue
- Cell Calcium
- Publisher
- Elsevier BV
- Published
- 2003-10
- Volume
- 34
- Issue
- 4-5
- Pages
- 345-363
- ISSN
- 0143-4160 (ISSN-L)
- OpenAlex
- W2038563918
- Cited by
- 197
- References
- 124
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 8 · 2019: 12 · 2018: 5 · 2017: 16 · 2016: 5 · 2015: 9 · 2014: 10 · 2013: 12 · 2012: 13
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell Calcium (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- endoplasmic reticulum calcium, ER calcium stores, unfolded protein response, endoplasmic reticulum stress, protein synthesis regulation, translational regulation, GRP78, ER chaperones, cytosolic free calcium, protein misfolding, embryonic cardiomyocytes, cell growth, ATP metabolism, mRNA translation regulation
- MeSH terms
- Endoplasmic Reticulum Chaperone BiP, Adenosine Triphosphate, Animals, Calcium, Carrier Proteins, Cell Division, Endoplasmic Reticulum, Gene Expression Regulation, Heat-Shock Proteins, Hormones, Humans, Hypertrophy, Models, Biological, Protein Processing, Post-Translational, Sarcoplasmic Reticulum, Protein Biosynthesis, Vasopressins, Eukaryotic Initiation Factor-2, Molecular Chaperones, Calcium Signaling, Myocytes, Cardiac
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