Ca2+/CREB/CBP-dependent gene regulation: a shared mechanism critical in long-term synaptic plasticity and neuronal survival
Abstract
CREB is a transcription factor critical for long-term synaptic plasticity. Intriguingly, recent work has elucidated a role for CREB, as well as upstream CREB kinases, in the control of activity-dependent neuronal survival. Additionally, analysis of the molecular pathology of polyglutamine-repeat diseases suggest that alteration of pCREB-CBP function may underlie, at least in part, the neurodegenerative process. Taken together, these new findings support the idea that Ca(2+)/CREB/CBP-dependent gene regulation might be a shared mechanism critical in both long-term synaptic plasticity and neuronal survival.
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CREB is important for cell survival.
“CREB is also important for cell survival (65,66).”
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Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila
Steffan, J. S., Bodai, L., Pallos, J., Poelman, M., McCampbell, A., Apostol, B. L., Kazantsev, A., Schmidt, E., Zhu, Y.-Z., Greenwald, M., et al. (2001) · Nature · doi:10.1038/35099568 · Cited by 1,228 · see citing works
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DaRocha-Souto, B., Coma, M., Pérez-Nievas, B. G., Scotton, T. C., Siao, M., Sánchez-Ferrer, P., Hashimoto, T., Fan, Z., Hudry, E., Barroeta, I., et al. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.09.002 · Cited by 180 · see citing works
Ljungberg, M. C., Ali, Y. O., Zhu, J., Wu, C.-S., Oka, K., Zhai, R. G., & Lu, H.-C. (2012) · Human Molecular Genetics · doi:10.1093/hmg/ddr492 · Cited by 107 · see citing works
Wang, G., An, T., Lei, C., Zhu, X., Yang, L., Zhang, L., & Zhang, R. (2022) · Journal of Ginseng Research · doi:10.1016/j.jgr.2021.03.005 · Cited by 101 · see citing works
- Authors
- Bito, H., & Takemoto-Kimura, S.
- Affiliations
- Kyoto University (JP)
- Corresponding author
- Bito, Haruhiko
- ORCID
- Bito, Haruhiko
- Venue
- Cell Calcium
- Publisher
- Elsevier BV
- Published
- 2003-10
- Volume
- 34
- Issue
- 4-5
- Pages
- 425-430
- ISSN
- 0143-4160 (ISSN-L)
- OpenAlex
- W1971851666
- Cited by
- 135
- References
- 1
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 6 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 9 · 2016: 6 · 2015: 3 · 2014: 5 · 2013: 9 · 2012: 7
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell Calcium (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Ministry of Health, Labour and Welfare
- Human Frontier Science Program
- Japan Science and Technology Corporation
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- CREB, CREB-binding protein, calcium signaling, transcriptional regulation, long-term synaptic plasticity, neuronal survival, activity-dependent gene expression, neurodegeneration
- MeSH terms
- Amino Acid Sequence, Animals, Calcium, Cell Survival, Gene Expression Regulation, Humans, Models, Biological, Molecular Sequence Data, Neuronal Plasticity, Neurons, Nuclear Proteins, Phylogeny, Protein Kinases, Transcription, Genetic, Trans-Activators, Cyclic AMP Response Element-Binding Protein, Sequence Homology, Amino Acid, Calcium-Calmodulin-Dependent Protein Kinases, Calcium Signaling, CREB-Binding Protein, Calcium-Calmodulin-Dependent Protein Kinase Type 4
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