The DOI matches its Crossref record; 205 of the 205 references it cites were found in a registry or an index.
Sensory neuropeptides: their role in inflammation and wound healing
Abstract
Vasoactive neuropeptides including substance P and calcitonin gene-related peptide (CGRP) are localised in sensory nerves which innervate blood vessels. These are the major vasoactive neuropeptides released from sensory nerve endings and both have been suggested to have roles in inflammatory and cardiovascular disease. The neuropeptides have potent effects on microvascular tone and permeability, which are seen soon after release from perivascular nerves. There is also evidence that neuropeptides can affect various activities of inflammatory cells and that sensory nerves play a role in the recovery of the healthy microcirculation during wound healing phases. This review concentrates on evidence that the neuropeptides substance P, acting via tachykinin NK1 and NK2 receptors, and CGRP, acting via CGRP1 receptors, play a pro-inflammatory role in disease and a beneficial role in wound healing. In addition, results from clinical trials of recently developed neuropeptide antagonists are discussed.
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“Similarly, genetic deletion or blockade of CGRP receptors has been suggested to be detrimental to wound healing58–60.”
From Neuropeptides Substance P and Calcitonin Gene Related Peptide Accelerate the Development and Fibrogenesis of Endometriosis (2019) · cites this paper as [58]
Citations
Cites
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Cited by
Sorted by citations
Vascular Actions of Calcitonin Gene-Related Peptide and Adrenomedullin
Brain, S. D., & Grant, A. D. (2004) · Physiological Reviews · doi:10.1152/physrev.00037.2003 · Cited by 765
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Metadata
- Authors
- Brain, S. D.
- Affiliations
- King's College London (GB)
- Corresponding author
- Brain, Susan D
- ORCID
- Brain, Susan D
- Venue
- Immunopharmacology
- Publisher
- Elsevier BV
- Published
- 1997-10
- Volume
- 37
- Issue
- 2-3
- Pages
- 133-152
- ISSN
- 0162-3109 (ISSN-L)
- OpenAlex
- W2086969402
- Cited by
- 246
- References
- 205
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 10 · 2023: 2 · 2022: 5 · 2021: 8 · 2020: 9 · 2019: 9 · 2018: 6 · 2017: 3 · 2016: 8 · 2015: 11 · 2014: 11 · 2013: 13 · 2012: 9
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Clinical Neurology › Migraine and Headache Studies
- Keywords
- sensory neuropeptides, substance P, calcitonin gene-related peptide, tachykinin NK1 receptor, tachykinin NK2 receptor, CGRP1 receptor, inflammation, wound healing, sensory nerves, microvascular tone, microvascular permeability, neuropeptide antagonists, perivascular nerves
- MeSH terms
- Amino Acid Sequence, Animals, Humans, Inflammation, Molecular Sequence Data, Neurons, Afferent, Neuropeptides, Wound Healing
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