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Long-lasting cognitive impairment in unipolar major depression: a 6-month follow-up study
Abstract
The aim of the study was to investigate cognitive impairment in major depression both acutely and after 6 months. All patients were investigated within a neurocognitive experimental setting at two testing sessions: at inclusion and after 6 months. Automatic and effortful information processing was investigated with a visual search paradigm. Twenty-one patients with recurrent major depression according to DSM-IV and a Hamilton Depression Rating Scale score >18 were included in the study. Healthy subjects, matched for age and gender, were used as a control group. The results showed that the depressed patients performed equal to the control group on trials requiring automatic information processing at both sessions. However, the patients were impaired compared to the control group on trials requiring effortful information processing, also at both sessions. The depressed patients showed no improvement in cognitive performance from test 1 to test 2. The results indicate that the depressed patients had an impaired performance for effortful, but not automatic, visual search performance, and that the impairment remained after 6 months, despite significant improvement in their depression scores.
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There are many reports of cognitive impairments that remain following antidepressant treatment that successfully reduces depressive symptomatology, even when remission of depressive symptoms is obtained.
“In contrast, there are many reports of cognitive impairments that remain following antidepressant treatment that successfully reduces depressive symptomatology [19–21], even when remission of depressive symptoms is obtained [22–24].”
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References 32 · Cited by 88
Research works printed but not linked: 1
- Kasper, S., Eder, H., 1994. Who should benefit from long-term antidepressant therapy? In: Mendlewicz, J., Glassmann, A. (Eds.), Depression as a Lifetime Disorder. Proceedings of the XIX CINP Congress, Washington, DC, pp. 17–28
Metadata
- Authors
- Hammar, Å., Lund, A., & Hugdahl, K.
- Affiliations
- University of Bergen (NO)
- Haukeland University Hospital (NO)
- Corresponding author
- Hammar, Åsa
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2003-05
- Volume
- 118
- Issue
- 2
- Pages
- 189-196
- ISSN
- 0165-1781 (ISSN-L)
- OpenAlex
- W2041086739
- Cited by
- 88
- References
- 32
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 6 · 2016: 4 · 2015: 5 · 2014: 6 · 2013: 8 · 2012: 7
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- cognitive impairment, unipolar major depression, recurrent depression, visual search, automatic information processing, long-term cognitive outcomes, neurocognitive function
- MeSH terms
- Adult, Cognition Disorders, Major Depressive Disorder, Female, Follow-Up Studies, Humans, Male, Middle Aged, Photic Stimulation, Psychiatric Status Rating Scales, Case-Control Studies
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