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Cited by 26Obsessive-Compulsive Spectrum DisordersAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychoanalysis and Psychopathology Research

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Improvement predictors in obsessive-compulsive disorder. An event-related potential study

Morault, Pierre, Guillem, François, Bourgeois, Marc, Paty, Jacques·1998·Psychiatry Research
DOI 10.1016/s0165-1781(98)00091-2
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Abstract

The treatment of patients with obsessive-compulsive disorder gives variable and unpredictable results. Numerous clinical features have been investigated as potential predictors of medication response but without consistent results. Preliminary findings have shown that some impairments of pre-treatment event-related potentials (ERPs) could be associated with future treatment outcome (Morault et al., 1997). The present study aimed to confirm the relationships between ERPs and treatment efficacy with larger sample sizes. ERP components were elicited during a verbal auditory 'oddball' paradigm and were recorded in 21 unmedicated patients compared to 21 control subjects. After a pharmacological treatment, the disorder improved in 12 patients. Pre-treatment ERP data were retrospectively compared between treatment responders, non-responders and control subjects. Patients who were to respond favorably to treatment had significantly reduced N2 amplitude and shorter N2 and P3 latencies compared to non-responders and control subjects. In contrast, no difference was shown between non-responders and control subjects. Our findings provide evidence for abnormalities of ERPs which could be considered as potential predictors of treatment response in patients with OCD. These results need to be tested in a prospective protocol.

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Metadata

Authors
Morault, P., Guillem, F., Bourgeois, M., & Paty, J.
Affiliations
  • Université de Bordeaux (FR)
  • Centre Hospitalier Charles Perrens (FR)
Corresponding author
Morault, Pierre
Venue
Psychiatry Research
Publisher
Elsevier BV
Published
1998-10
Volume
81
Issue
1
Pages
87-96
ISSN
0165-1781 (ISSN-L)
DOI
10.1016/s0165-1781(98)00091-2
OpenAlex
W1997252766
Cited by
26
References
30
Citations by year
2024: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2012: 1
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychiatry Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
Keywords
obsessive-compulsive disorder, treatment response prediction, event-related potentials, N2 component, P300, oddball paradigm, pharmacotherapy, treatment outcomes
MeSH terms
Adult, Evoked Potentials, Female, Follow-Up Studies, Humans, Male, Middle Aged, Obsessive-Compulsive Disorder, Prognosis, Retrospective Studies

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CoChat. (2026). Citation check: Improvement predictors in obsessive-compulsive disorder. An event-related potential study. https://app.cochat.ai/papers/10.1016/s0165-1781(98)00091-2
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Morault, P., Guillem, F., Bourgeois, M., & Paty, J. (1998). Improvement predictors in obsessive-compulsive disorder. An event-related potential study. Psychiatry Research. https://doi.org/10.1016/s0165-1781(98)00091-2