Four Cases of Follicular Lymphoma with t(14;18)(q32;q21) and t(3;4)(q27;p13) with LAZ3 (BCL6) Rearrangement
Abstract
We report four cases of follicular lymphoma with both t(14;18)(q32;q21) and the newly characterized t(3;4)(q27;p13). Molecular investigation confirmed LAZ3 (BCL6) rearrangement for all patients. The 3q27 aberrations have been rarely described in low-grade lymphomas and may represent secondary events whose implication remains to be elucidated.
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The t(3;4)(q27;p13) translocation between LAZ3/BCL6 and RHOH is often a secondary event in follicular lymphoma.
“While a BCL2 translocation is found in 85% of FL cases and can be considered the primary cause of the disease, the t(3;4)(q27;p13) translocation between LAZ3/BCL6 and RHOH is often a secondary event [40].”
From The small GTPase RhoH is an atypical regulator of haematopoietic cells (2008) · cites this paper as [40]
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The small GTPase RhoH is an atypical regulator of haematopoietic cells
Fueller, F., & Kubatzky, K. F. (2008) · Cell Communication and Signaling · doi:10.1186/1478-811x-6-6 · Cited by 40 · see citing works
- Authors
- Daudignon, A., Bisiau, H., Le Baron, F., Laı̈, J.-L., Wetterwald, M., Galiègue-Zouitina, S., Morel, P., & Duthilleul, P.
- Affiliations
- Centre Hospitalier de Valenciennes (FR)
- Centre Hospitalier de Lens (FR)
- Corresponding author
- Daudignon, Agnès
- Venue
- Cancer Genetics and Cytogenetics
- Publisher
- Elsevier BV
- Published
- 1999-06
- Volume
- 111
- Issue
- 2
- Pages
- 157-160
- ISSN
- 0165-4608 (ISSN-L)
- OpenAlex
- W2163899452
- Cited by
- 14
- References
- 0
- Citations by year
- 2025: 1 · 2015: 1
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Genetics and Cytogenetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Health Sciences › Medicine › Genetics › Chronic Lymphocytic Leukemia Research
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Keywords
- follicular lymphoma, 18)(q32, BCL6 rearrangement, secondary chromosomal aberrations, indolent lymphoma, molecular cytogenetics
- MeSH terms
- Adult, Aged, Chromosomes, Human, Chromosomes, Human, Pair 14, Chromosomes, Human, Pair 18, Chromosomes, Human, Pair 3, Chromosomes, Human, Pair 4, DNA-Binding Proteins, Female, Humans, Karyotyping, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Middle Aged, Proto-Oncogene Proteins, Transcription Factors, Translocation, Genetic, Blotting, Southern, Gene Rearrangement, B-Lymphocyte, Zinc Fingers, Proto-Oncogene Proteins c-bcl-6
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