Interleukin-6 and the development of social disruption-induced glucocorticoid resistance
Abstract
Following social disruption (SDR) stress in male mice, corticosterone resistance of splenocytes was accompanied by enhanced LPS-stimulated interleukin (IL)-6 secretion. The present study examined the role of IL-6 in the development of corticosterone resistance. Addition of IL-6 to control splenocyte cultures did not induce corticosterone resistance. SDR also elevated IL-6 in plasma and liver, but not in spleen. IL-6 deficient mice that were exposed to SDR developed glucocorticoid resistance despite the absence of systemic IL-6. These findings suggest that although SDR enhanced IL-6 responses, IL-6 was not essential for the development of stress-induced splenocyte corticosterone resistance.
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Glucocorticoid resistance occurs when immune cells become less sensitive to the anti-inflammatory effects of glucocorticoids due to persistent or repeated HPA axis activation.
“occurs when immune cells become less sensitive to the anti-inflammatory effects of glucocorticoids as a consequence of persistent or repeated activation of the HPA axis”
From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Stark et al, 2002
Repeated social defeat induces a robust increase in plasma IL-6.
“RSD also induced a robust increase in plasma IL-6 [17, 23].”
From Interleukin-6 Induced by Social Stress Promotes a Unique Transcriptional Signature in the Monocytes That Facilitate Anxiety (2019) · cites this paper as [23]
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References 27 · Cited by 114
- Authors
- Stark, J. L., Avitsur, R., Hunzeker, J., Padgett, D. A., & Sheridan, J. F.
- Affiliations
- The Ohio State University (US)
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2002-03
- Volume
- 124
- Issue
- 1-2
- Pages
- 9-15
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W1989128330
- Cited by
- 114
- References
- 27
- Citations by year
- 2026: 1 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 4 · 2018: 6 · 2017: 4 · 2016: 8 · 2015: 5 · 2014: 3 · 2013: 3 · 2012: 8
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- John D. and Catherine T. MacArthur Foundation
- National Institutes of Health (1f31mh011792-01)
- National Institute of Mental Health (R01 MH46801-08, F31 MH11792, R01MH046801)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Keywords
- interleukin-6, glucocorticoid resistance, corticosterone, splenocytes, IL-6 deficiency, stress-induced immunosuppression, neuroimmune interactions
- MeSH terms
- Animals, Corticosterone, Drug Resistance, Interpersonal Relations, Lipopolysaccharides, Male, Mice, Inbred C57BL, Spleen, Stress, Psychological, Interleukin-6, Mice
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