An ‘oligarchy’ rules neural development
Abstract
Recent reports show that Olig genes, which encode the basic helix-loop-helix Olig transcription factors, are essential for development of oligodendrocytes. Surprisingly, Olig function is also required for formation of somatic motor neurons. These findings alter our views of how the oligodendrocyte lineage is generated and raise further questions about the underlying developmental relationships between neurons and glia.
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OLIG2 is a chromosome 21-encoded gene that is a master regulator for oligodendrocyte development.
“Much of the work in DS has focused on OLIG2, a chromosome 21-encoded gene that is a master regulator for oligodendrocyte development92,93,108.”
From Consequences of trisomy 21 for brain development in Down syndrome (2024) · cites this paper as [93]
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References 52 · Cited by 181
- Authors
- Rowitch, D. H., Lu, Q. R., Kessaris, N., & Richardson, W. D.
- Affiliations
- Harvard University (US)
- University College London (GB)
- Corresponding author
- Rowitch, David H.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2002-08
- Volume
- 25
- Issue
- 8
- Pages
- 417-422
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2068227227
- Cited by
- 181
- References
- 52
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 6 · 2023: 3 · 2022: 7 · 2021: 4 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 11 · 2013: 5 · 2012: 5
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- bHLH transcription factors, oligodendrocyte lineage, neural development, neuron-glia interactions, oligodendrocyte differentiation
- MeSH terms
- Oligodendrocyte Transcription Factor 2, Animals, Cell Differentiation, Central Nervous System, DNA-Binding Proteins, Humans, Motor Neurons, Nerve Tissue Proteins, Oligodendroglia, Stem Cells, Transcription Factors, Mice, Knockout, Gene Expression Regulation, Developmental, Cell Lineage, Mice, Basic Helix-Loop-Helix Proteins
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