Endogenous oxytocin is involved in short-term olfactory memory in female rats
Abstract
To investigate the involvement of oxytocin in their short-term lasting olfactory memory performance, adult female Wistar rats (n = 12) were tested for their juvenile discrimination abilities. As measured by their exploratory behavior towards juveniles, the adult rats were able to discriminate between a previously exposed juvenile and a novel one as long as the interval between the two exposures was less than 180 min. This ability was maintained across all days of the estrous cycle and was unaffected by intracerebroventricular administration of synthetic oxytocin (1 ng/5 microl Ringer's solution) or Ringer's solution immediately after the first exposure. However, treatment with the oxytocin receptor antagonist des-Gly-NH2 d(CH2)5[Tyr(Me)2Thr4]OVT interfered with the ability to establish this kind of olfactory memory although the vasopressin V1 receptor antagonist d(CH2)5Tyr(Me)AVP (100 ng/5 microl each) via the same route did not. This suggests that within a narrow range of concentrations endogenous oxytocin, but not vasopressin, is critically involved in short-term olfactory memory for juvenile conspecifics in female rats. These data are discussed in the light of sexual dimorphic brain development.
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Social discrimination is a complex behavior, and several other signaling molecules have been shown to play a role in social discrimination, including oxytocin and arginine vasopressin.
“social discrimination is a complex behavior, and several other signaling molecules have been shown to play a role in social discrimination, including oxytocin [35–37] and arginine vasopressin [24, 38–40].”
From Sex-specific effects of neonatal progestin receptor antagonism on juvenile social play behavior in rats (2021) · cites this paper as [35]
ICV administration of an OTR antagonist impaired social recognition in both male and female rats.
“ICV administration of an OTR antagonist impaired social recognition in both male (Lukas et al., 2013) and female (Engelmann et al., 1998) rats.”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Engelmann et al., 1998
ICV OT improved social recognition in male, but not female, rats.
“ICV OT improved social recognition in male (Benelli et al., 1995), but not in female (Engelmann et al., 1998) rats.”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Engelmann et al., 1998
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References 36 · Cited by 156
- Authors
- Engelmann, M., Ebner, K., Wotjak, C. T., & Landgraf, R.
- Affiliations
- Max Planck Institute of Psychiatry (DE)
- Max Planck Society (DE)
- Corresponding author
- Engelmann, Mario
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 1998-01
- Volume
- 90
- Issue
- 1
- Pages
- 89-94
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2113872892
- Cited by
- 156
- References
- 36
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 2 · 2019: 8 · 2018: 9 · 2017: 9 · 2016: 6 · 2015: 10 · 2014: 10 · 2013: 6 · 2012: 11
- FWCI
- 6.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- oxytocin, olfactory memory, short-term memory, female rats, social recognition, oxytocin receptor antagonist, V1 vasopressin receptor, estrous cycle, sexual dimorphism, brain development, intracerebroventricular administration
- MeSH terms
- Animals, Discrimination, Psychological, Estrus, Female, Injections, Intraventricular, Memory, Short-Term, Oxytocin, Smell, Social Behavior, Rats, Wistar, Rats
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