The DOI matches its Crossref record; 47 of the 48 references it cites were found in a registry or an index.
Associations among antimicrobial drug treatments and antimicrobial resistance of fecal Escherichia coli of swine on 34 farrow-to-finish farms in Ontario, Canada
Abstract
Logistic regression was used to model associations between antimicrobial treatment and resistance among fecal Escherichia coli of finisher pigs at the farm level. Four sets of potential risk factors representing different levels of refinement of antimicrobial use on farms were modelled on resistance to antimicrobials. Final models for each antimicrobial were constructed from treatment and management variables significant on initial screening, and corrections for overdispersion were made. In general, in-feed antimicrobial treatment of pigs was more consistently associated with an increased risk of resistance than individual-animal treatment. Antimicrobial treatment in starter rations was significant in final models of resistance to ampicillin, carbadox, nitrofurantoin, sulfisoxizole, and tetracycline. Treatment in grower-finisher rations was significantly associated with resistance to ampicillin, spectinomycin, sulfisoxizole, and tetracycline. There was little evidence that in-feed antimicrobials increased the risk of resistance to gentamicin, which is a drug used only for individual-pig treatment in this study population. These results suggest that antimicrobial medication of rations of post-weaning pigs selects for and maintains antimicrobial resistance among E. coli of finisher pigs. Although resistance was common on farms that did not medicate rations of post-weaning pigs, the results indicate that antimicrobial use does increase the risk of resistance to the antimicrobials studied.
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“Scientifically based investigations suggest a strong relationship between antibiotic use in food animals and the development of antibiotic resistance by bacteria associated with farm animals [88,89,90].”
From The Food Production Environment and the Development of Antimicrobial Resistance in Human Pathogens of Animal Origin (2017) · cites this paper as [89]
Citations
Cites
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Research works printed but not linked: 5
- Dunlop, R.H., 1996. Antimicrobial treatments and antimicrobial resistance of fecal Escherichia coli of swine in Ontario, Canada. PhD dissertation. University of Guelph, Guelph, Ontario, 351 pp.
- English, P.R., Fowler, V.R., Baxter, S., Smith, B., 1988. The Growing and Finishing Pig: Improving Efficiency. Farming Press, Ipswich, p. 289.
- Institute of Medicine, 1988. Human Health Risks with the Subtherapeutic Use of Penicillin or Tetracyclines in Animal Feeds. National Academy Press, Washington, DC.
- MacKinnon, J.D., 1981. The use of tylosin in feed and therapy—a review. In: Ten Years on from Swann. Association of Veterinarians in Industries, London, pp. 51–70.
- Snedecor, G.W., Cochran, W.G., 1989. Statistical Methods, 8th edn. Iowa State Univ. Press, Ames, 503 pp.
Cited by
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Antimicrobial use and resistance in animals.
Mcewen, S., & Fedorka-Cray, P. (2002) · Clinical Infectious Diseases · doi:10.1086/340246 · Cited by 1,031
Self-citationAntibiotic use in animal feed and its impact on human healt
BARTON, M. D. (2000) · Nutrition Research Reviews · doi:10.1079/095442200108729106 · Cited by 516
Resistance in bacteria of the food chain: Epidemiology and control strategies
Aarestrup, F. M., Wegener, H. C., & Collignon, P. (2008) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.6.5.733 · Cited by 406
Munk, P., Knudsen, B. E., Lukjančenko, O., Duarte, A. S. R., Gompel, L. V., Luiken, R. E. C., Smit, L. A. M., Schmitt, H., Dorado-García, A., Hansen, R. B., et al. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0192-9 · Cited by 363
Murphy, D., Ricci, A., Auce, Z., Beechinor, J. G., Bergendahl, H., Breathnach, R., Bureš, J., Silva, J. P. D. D., Hederová, J., Hekman, P., et al. (2017) · EFSA Journal · doi:10.2903/j.efsa.2017.4666 · Cited by 348
Metadata
- Authors
- Dunlop, R. H., McEwen, S. A., Meek, A. H., Clarke, R. C., Black, W. D., & Friendship, R. M.
- Affiliations
- University of Guelph (CA)
- Health Canada (CA)
- Corresponding author
- McEwen, S.A
- Venue
- Preventive Veterinary Medicine
- Publisher
- Elsevier BV
- Published
- 1998-03
- Volume
- 34
- Issue
- 4
- Pages
- 283-305
- ISSN
- 0167-5877 (ISSN-L)
- OpenAlex
- W2049413527
- Cited by
- 109
- References
- 48
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 3 · 2022: 1 · 2021: 8 · 2020: 6 · 2019: 6 · 2018: 3 · 2017: 9 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 6 · 2012: 2
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Preventive Veterinary Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Health Sciences › Veterinary › Small Animals › Veterinary medicine and infectious diseases
- Keywords
- antimicrobial resistance, Escherichia coli, pigs, fattening pigs, antimicrobial therapy, risk factors, ampicillin, tetracycline, carbadox, nitrofurantoin, spectinomycin, gentamicin, farrow-to-finish farms, Ontario
- MeSH terms
- Animals, Animal Husbandry, Anti-Bacterial Agents, Drug Resistance, Microbial, Escherichia coli, Escherichia coli Infections, Models, Theoretical, Ontario, Regression Analysis, Risk Factors, Swine, Swine Diseases
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