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Altering the glycosylation pattern of bioactive compounds
Open accessAbstract
Many bioactive natural products are glycosylated compounds in which the sugars are important or essential for biological activity. The isolation of several sugar biosynthesis gene clusters and glycosyltransferases from different antibiotic-producing organisms, and the increasing knowledge about these biosynthetic pathways opens up the possibility of generating novel bioactive compounds through combinatorial biosynthesis in the near future. Recent advances in this area indicate that antibiotic glycosyltransferases show some substrate flexibility that might allow us to alter the types of sugar transferred to the different aglycons or, less frequently, to change the position of its attachment.
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Citations
Cited by
Natural Products Version 2.0: Connecting Genes to Molecules
Walsh, C. T., & Fischbach, M. A. (2010) · Journal of the American Chemical Society · doi:10.1021/ja909118a · Cited by 468
Natural‐Product Sugar Biosynthesis and Enzymatic Glycodiversification
Thibodeaux, C. J., Melançon, C. E., & Liu, H. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200801204 · Cited by 444
Enzyme technology: an overview
Beilen, J. B. V., & Li, Z. (2002) · Current Opinion in Biotechnology · doi:10.1016/s0958-1669(02)00334-8 · Cited by 320
In vitro characterization of IroB, a pathogen-associated C -glycosyltransferase
Fischbach, M. A., Lin, H., Liu, D. R., & Walsh, C. T. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408463102 · Cited by 169
S-layer nanoglycobiology of bacteria
Messner, P., Steiner, K., Zarschler, K., & Schäffer, C. (2008) · Carbohydrate Research · doi:10.1016/j.carres.2007.12.025 · Cited by 90
Metadata
- Authors
- Méndez, C., & Salas, J. A.
- Venue
- Trends in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2001-11
- Volume
- 19
- Issue
- 11
- Pages
- 449-456
- ISSN
- 0167-7799 (ISSN-L)
- OpenAlex
- W2132387742
- Cited by
- 175
- References
- 0
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- green
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