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Acute toxicity of adjuvant doxorubicin and cyclophosphamide for early breast cancer – a retrospective review of Chinese patients and comparison with an historic Western series

Ma, Brigette, Yeo, Winnie, Hui, Pun, Ho, Wing M, Johnson, Philip J·2002·Radiotherapy and Oncology
DOI 10.1016/s0167-8140(02)00003-8
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Abstract

A cohort of 85 Chinese breast cancer patients who received adjuvant chemotherapy with doxorubicin and cyclophosphamide was found to have a significantly higher incidence of grade 3 (n=44, 52%) and grade 4 (n=21, 25%) neutropenia when compared with an historic Western cohort. Also noted was a higher incidence of hepatotoxicity (n=8, 9%). When compared to Caucasian patients, the higher myelotoxicity in our patients may be related to ethnic variation in susceptibility to chemotherapy-related toxicity, lower body mass index with higher percentage of body fat composition, and the popular practice of concurrent alternative medicine during chemotherapy. The higher incidence of hepatoxicity was possibly associated with endemic chronic hepatitis B infection in this geographical area.

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Crossref · 10.1016/s0167-8140(02)00003-8

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  • Liver injury caused by antineoplastic or immunomodulators includes hepatocyte necrosis, hepatic steatosis, hepatic mitochondrial injury, cholestasis and vascular injury.

    “Liver injury caused by antineoplastic or immunomodulators includes hepatocyte necrosis, hepatic steatosis, hepatic mitochondrial injury, cholestasis and vascular injury.[42][43][44][45]”

    From Incidence and Etiology of Drug-Induced Liver Injury in Mainland China (2019) · cites this paper as [44]

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Research works printed but not linked: 19

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  15. Poikonen, 2001, Effect of obesity on the leukocyte nadir in women treated with adjuvant cyclophosphamide, methotrexate, and fluorouracil dosed according to body surface area, Acta Oncol, 40, 67, 10.1080/028418601750071082 · DOI
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Metadata

Authors
Ma, B., Yeo, W., Hui, P., Ho, W. M., & Johnson, P. J.
Venue
Radiotherapy and Oncology
Publisher
Elsevier BV
Published
2002-02
Volume
62
Issue
2
Pages
185-189
ISSN
0167-8140
DOI
10.1016/s0167-8140(02)00003-8
Cited by
48
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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