The influence of manufacturing procedure on the degradation of poly(lactide-co-glycolide) 85:15 and 50:50 implants
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Glycolic acid from PLGA is excreted renally, while lactic acid enters the Krebs cycle and is metabolized to carbon dioxide and water.
“These monomers are naturally eliminated: glycolic acid is excreted renally, while lactic acid enters the Krebs cycle and is metabolized to carbon dioxide and water [232].”
From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [232]
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In vitro and in vivo release of ciprofloxacin from PLGA 50:50 implants
Ramchandani, M., & Robinson, D. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00113-2 · Cited by 195 · see citing works
Self-citationBiomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering
Fazel Anvari-Yazdi, A., Badea, I., & Chen, X. (2025) · Gels · doi:10.3390/gels11060441 · Cited by 20 · see citing works
- Authors
- Ramchandani, M., Pankaskie, M., & Robinson, D.
- Affiliations
- Integra LifeSciences (United States) (US)
- University of Pittsburgh Medical Center (US)
- University of Nebraska Medical Center (US)
- Corresponding author
- Ramchandani, Monica
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 1997-01
- Volume
- 43
- Issue
- 2-3
- Pages
- 161-173
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W2004810787
- Cited by
- 86
- References
- 0
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 5 · 2023: 1 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 1 · 2013: 4 · 2012: 3
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Controlled Release (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Magnesium Alloys: Properties and Applications
- Keywords
- poly(lactic-co-glycolic acid), PLGA implants, in vitro degradation, production process, non-solvent induced phase separation, microcapsules, molecular weight reduction, pseudo-first-order kinetics, surface morphology, porosity, water absorption, pH effect on degradation
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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