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Continuous glucose monitoring used to adjust diabetes therapy improves glycosylated hemoglobin: a pilot study

Bode, Bruce W., Gross, Todd M., Thornton, Kay R., Mastrototaro, John J.·1999·Diabetes Research and Clinical Practice

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Abstract

A 5-week pilot study was conducted to determine if continuous glucose monitoring could be used to improve glycemic control. A total of nine subjects with type 1 diabetes and HbA1c values greater than 8.5% completed the study. Subjects wore a continuous glucose monitor for two 1-week periods during the study. After each sensor use, changes to diet, insulin dosage and self-monitored blood glucose (SMBG) schedule were made. HbA1c decreased from 9.9% (S.D. = 1.1%) at baseline to 8.8% (S.D. = 1.0%) 5 weeks after baseline (P = 0.0006), but daily insulin usage was unchanged over the same period of time (P = 0.428). The glucose sensors performed accurately, with a median correlation of 0.92 and a mean absolute difference of 19.1% (S.D. = 9.0%). The continuous glucose profiles allowed identification of glucose patterns and excursions that helped direct changes in therapy. These treatment changes would not have been made on the basis of meter data alone and were effective in improving glucose control. Additional studies are needed to validate these findings. This pilot study highlights the potential for continuous glucose monitoring to provide the valuable information necessary to make therapy adjustments that can dramatically improve patients' glycemic control and reduce the risk of long-term complications.

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“These results should be interpreted with caution, due to the lack of a randomized control group in this study, the selection of patients with elevated HbA1c levels, and the potential influence of the Hawthorne effect [5].”
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Authors: Bode, B. W., Gross, T. M., Thornton, K. R., & Mastrototaro, J. J.
Affiliations: Atlanta Diabetes Associates (US)
Corresponding author: Bode, Bruce W.
ORCID: Bode, Bruce W.
Gross, Todd M.
Mastrototaro, John J.
Venue: Diabetes Research and Clinical Practice
Publisher: Elsevier BV
Published: 1999-12
Volume: 46
Issue: 3
Pages: 183-190
ISSN: 0168-8227 (ISSN-L)
DOI: 10.1016/s0168-8227(99)00113-8
OpenAlex: W2103516801
Cited by: 232
References: 5
Citations by year: 2025: 1 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 9 · 2015: 6 · 2014: 4 · 2013: 5 · 2012: 6
FWCI: 8.41
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Diabetes Research and Clinical Practice (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: continuous glucose monitoring, type 1 diabetes, glycemic control, HbA1c, insulin dose adjustment, self-monitoring of blood glucose
MeSH terms: Adolescent, Adult, Blood Glucose, Diabetes Mellitus, Type 2, Female, Glycated Hemoglobin, Humans, Insulin, Male, Middle Aged, Monitoring, Physiologic, Pilot Projects, Therapy, Computer-Assisted, Treatment Outcome

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Continuous glucose monitoring used to adjust diabetes therapy improves glycosylated hemoglobin: a pilot study

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