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Chronic active hepatitis caused by benzarone
Abstract
We report a case of chronic active hepatitis caused by benzarone, a benzofuran derivative used in Europe for the treatment of peripheral venous disorders. Jaundice and serum alanine aminotransferase activity increased while drug administration was continued, but promptly decreased when it was eventually interrupted. Liver lesions were those of chronic active hepatitis. Anti-smooth muscle antibodies were present at a titer of 1:500 and disappeared 8 months after withdrawal of benzarone.
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Metabolites from dihydralazine and tienilic acid coupled with cellular proteins can form neoantigens inducing immune reactions and causing DI-ALH.
“Metabolites from dihydralazine and tienilic acid coupled with cellular proteins can form neoantigens4 inducing immune reactions and causing DI-ALH.”
From Nomenclature, diagnosis and management of drug-induced autoimmune-like hepatitis (DI-ALH): An expert opinion meeting report (2023) · cites this paper as [33]
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Research works printed but not linked: 26
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Central role of mitochondria in drug-induced liver injury
Pessayre, D., Fromenty, B., Berson, A., Robin, M.-A., Lettéron, P., Moreau, R., & Mansouri, A. (2012) · Drug Metabolism Reviews · doi:10.3109/03602532.2011.604086 · Cited by 277
Self-citationAndrade, R. J., Aithal, G. P., de Boer, Y. S., Liberal, R., Gerbes, A., Regev, A., Terziroli Beretta-Piccoli, B., Schramm, C., Kleiner, D. E., De Martin, E., et al. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.04.033 · Cited by 166
Metadata
- Authors
- Babany, G., Larrey, D., Pessayre, D., Degott, C., Rueff, B., & Benhamou, J.-P.
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 1987-01
- Volume
- 5
- Issue
- 3
- Pages
- 332-335
- ISSN
- 0168-8278
- Cited by
- 27
- References
- 0
- Language
- en
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