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New uses for new haplotypes

Jobling, Mark A., Tyler-Smith, Chris·2000·Trends in Genetics
DOI 10.1016/s0168-9525(00)02057-6
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Abstract

Recent discoveries of many new genes have made it clear that there is more to the human Y chromosome than a heap of evolutionary debris, hooked up to a sequence that happens to endow its bearer with testes. Coupled with the recent development of new polymorphic markers on the Y, making it the best-characterized haplotypic system in the genome, this gives us new opportunities to assess its role in disease and selection, through association studies with phenotypes such as infertility and cancers. However, the peculiar genetics of this bizarre chromosome means that we should interpret such studies particularly cautiously.

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Metadata

Authors
Jobling, M. A., & Tyler-Smith, C.
Venue
Trends in Genetics
Publisher
Elsevier BV
Published
2000-08
Volume
16
Issue
8
Pages
356-362
ISSN
0168-9525
DOI
10.1016/s0168-9525(00)02057-6
Cited by
82
References
2
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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Jobling, M. A., & Tyler-Smith, C. (2000). New uses for new haplotypes. Trends in Genetics. https://doi.org/10.1016/s0168-9525(00)02057-6