Induced gene expression in human brain after the split from chimpanzee
Abstract
Despite only approximately 1% difference in genomic DNA sequence, humans and chimpanzees differ considerably in mental and linguistic capabilities, and in susceptibility to some diseases. A recent comparison of gene expression in human and great apes cast some light on the genetic basis of these differences, but more rigorous study is required. Our statistical reanalysis of these microarray data shows that there have indeed been dramatic alterations in the expression of genes in the human brain since the split from chimpanzees, mainly caused by a set of genes with increased (rather than decreased) expression in the human brain.
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This finding is consistent with previous microarray gene expression profiling studies, extending the conclusion further by providing cellular level details.
“This finding is consistent with previous microarray gene expression profiling studies (Caceres et al., 2003; Gu and Gu, 2003; Johnson et al., 2009; Miller et al., 2010; Oldham et al., 2008), extending the conclusion further by providing cellular level details.”
From Large-Scale Cellular-Resolution Gene Profiling in Human Neocortex Reveals Species-Specific Molecular Signatures (2012) · cites this paper as Gu and Gu, 2003
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References 12 · Cited by 119
- Authors
- Gu, J., & Gu, X.
- Affiliations
- Iowa State University (US)
- Corresponding author
- Gu, Xun
- ORCID
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 2003-02
- Volume
- 19
- Issue
- 2
- Pages
- 63-65
- ISSN
- 0168-9525 (ISSN-L)
- OpenAlex
- W2040618467
- Cited by
- 119
- References
- 12
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2020: 6 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 6
- FWCI
- 8.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Social Sciences › Anthropology › Pleistocene-Era Hominins and Archaeology
- Keywords
- human-chimpanzee divergence, gene expression evolution, human brain, chimpanzees, great apes, brain gene expression, human cognitive evolution, neuroanatomical differences
- MeSH terms
- Animals, Brain, Pan troglodytes, Biological Evolution, Humans, Liver, Phylogeny, Probability, Reference Values, Species Specificity, Gene Expression
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